CKS1B CDC28 protein kinase regulatory subunit 1B [Homo sapiens (human)] - Gene

Summary

Official Symbol: CKS1Bprovided by HGNC
Official Full Name: CDC28 protein kinase regulatory subunit 1Bprovided by HGNC
Primary source: HGNC:HGNC:19083
See related: Ensembl:ENSG00000173207 MIM:116900; AllianceGenome:HGNC:19083
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CKS1; ckshs1; PNAS-16; PNAS-18
Summary: CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein. At least two transcript variants have been identified for this gene, and it appears that only one of them encodes a protein. [provided by RefSeq, Sep 2008]
Expression: Ubiquitous expression in bone marrow (RPKM 29.0), fat (RPKM 22.7) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q21.3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (154974681..154979251)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (154114042..154118612)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (154947157..154951727)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of microRNA miR-197-3p/CDC28 protein kinase regulatory subunit 1B (CKS1B) axis by Circular RNA hsa_circ_0000285 promotes glioma progression.
Title: Regulation of microRNA miR-197-3p/CDC28 protein kinase regulatory subunit 1B (CKS1B) axis by Circular RNA hsa_circ_0000285 promotes glioma progression.
Establishment of high-throughput screening HTRF assay for identification small molecule inhibitors of Skp2-Cks1.
Title: Establishment of high-throughput screening HTRF assay for identification small molecule inhibitors of Skp2-Cks1.
A Pan-Cancer Analysis of Clinical Prognosis and Immune Infiltration of CKS1B in Human Tumors.
Title: A Pan-Cancer Analysis of Clinical Prognosis and Immune Infiltration of CKS1B in Human Tumors.
CKS1B promotes cell proliferation and invasion by activating STAT3/PD-L1 and phosphorylation of Akt signaling in papillary thyroid carcinoma.
Title: CKS1B promotes cell proliferation and invasion by activating STAT3/PD-L1 and phosphorylation of Akt signaling in papillary thyroid carcinoma.
The survival impact of CKS1B gains or amplification is dependent on the background karyotype and TP53 deletion status in patients with myeloma.
Title: The survival impact of CKS1B gains or amplification is dependent on the background karyotype and TP53 deletion status in patients with myeloma.
Circular RNA NOX4 promotes the development of colorectal cancer via the microRNA4855p/CKS1B axis.
Title: Circular RNA NOX4 promotes the development of colorectal cancer via the microRNA‑485‑5p/CKS1B axis.
High Cks1 expression predicted poorer prognosis and worse clinicopathological parameters in various cancers. Increased Cks1 could be a significant prognostic biomarker for poor survival in patients with various cancers. Meta-analysis.
Title: Prognostic and clinicopathological significance of Cks1 in cancer: Evidence from a meta-analysis.
Considering the highly increased levels of CKS1B and decreased expression of miR-1258 in tumors from CRC patients, these findings suggest that miR-1258 may play tumor-suppressive roles by targeting CKS1B expression in CRC.
Title: MicroRNA-1258 Inhibits the Proliferation and Migration of Human Colorectal Cancer Cells through Suppressing CKS1B Expression.
The key observations of the present study demonstrated that shCKS1B can inhibit the proliferation, invasion and angiogenesis of Retinoblastoma cells by suppressing the MEK/ERK signaling pathway.
Title: Downregulation of CKS1B restrains the proliferation, migration, invasion and angiogenesis of retinoblastoma cells through the MEK/ERK signaling pathway.
the data propose a novel function for Cks1 as a tumor promoter through the expression of the strongly oncogenic protein osteopontin (OPN) in human hepatocellular carcinoma (HCC).
Title: Cks1 regulates human hepatocellular carcinoma cell progression through osteopontin expression.

Submit: New GeneRIF Correction See all GeneRIFs (54)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2279 (e-PCR)
- UniSTS:473907

D1S1361 (e-PCR)
- UniSTS:149557

D17S1978 (e-PCR)
- UniSTS:43349

D15S1477 (e-PCR)
- UniSTS:474482

KS608 (e-PCR)
- UniSTS:253179

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in fibroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle phase transition	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	TAS Traceable Author Statement more info

General protein information

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Preferred Names: cyclin-dependent kinases regulatory subunit 1

Names: CDC2-associated protein CKS1; CDC28 protein kinase 1B; NB4 apoptosis/differentiation related protein; cell division control protein CKS1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001826.3 → NP_001817.1 cyclin-dependent kinases regulatory subunit 1

See identical proteins and their annotated locations for NP_001817.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) is the protein-coding variant.

Source sequence(s)

AL451085, BQ883992, CN347951

Consensus CDS

CCDS1077.1

UniProtKB/Swiss-Prot

P33551, P61024

UniProtKB/TrEMBL

Q5T178

Related

ENSP00000311083.5, ENST00000308987.6

Conserved Domains (1) summary

pfam01111
Location:8 → 73

CKS; Cyclin-dependent kinase regulatory subunit

RNA

NR_024163.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses a different splice site at the 3' end of the first exon compared to variant 1. There is no evidence that this variant encodes a protein.

Source sequence(s)

AL451085, BQ883992, CB161621, CN347951

Related

ENST00000368439.5