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    Hsf2bp heat shock transcription factor 2 binding protein [ Mus musculus (house mouse) ]

    Gene ID: 74377, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Hsf2bpprovided by MGI
    Official Full Name
    heat shock transcription factor 2 binding proteinprovided by MGI
    Primary source
    MGI:MGI:1921627
    See related
    Ensembl:ENSMUSG00000002076 AllianceGenome:MGI:1921627
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Meilb2; 4932437G14Rik
    Summary
    Involved in meiosis I and spermatogenesis. Located in chromosome. Is expressed in several structures, including genitourinary system; nervous system; sensory organ; surface ectoderm; and thymus. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 19. Orthologous to human HSF2BP (heat shock transcription factor 2 binding protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 5.3), kidney adult (RPKM 0.7) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 B1; 17 17.25 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (32163743..32253869, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (31944769..32034895, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310015A16 gene Neighboring gene predicted gene, 30571 Neighboring gene STARR-seq mESC enhancer starr_42364 Neighboring gene ribosomal RNA processing 1B Neighboring gene STARR-seq mESC enhancer starr_42366 Neighboring gene STARR-positive B cell enhancer ABC_E4204 Neighboring gene pyridoxal (pyridoxine, vitamin B6) kinase, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. HSF2BP protects against acute liver injury by regulating HSF2/HSP70/MAPK signaling in mice. Bi J, et al. Cell Death Dis, 2022 Sep 27. PMID 36167792, Free PMC Article
    2. HSF2BP negatively regulates homologous recombination in DNA interstrand crosslink repair. Sato K, et al. Nucleic Acids Res, 2020 Mar 18. PMID 31960047, Free PMC Article
    3. HSF2BP represses BNC1 transcriptional activity by sequestering BNC1 to the cytoplasm. Wu Y, et al. FEBS Lett, 2013 Jul 11. PMID 23707421
    4. MEIOK21: a new component of meiotic recombination bridges required for spermatogenesis. Shang Y, et al. Nucleic Acids Res, 2020 Jul 9. PMID 32463460, Free PMC Article
    5. Meiosis-Specific C19orf57/4930432K21Rik/BRME1 Modulates Localization of RAD51 and DMC1 to DSBs in Mouse Meiotic Recombination. Takemoto K, et al. Cell Rep, 2020 May 26. PMID 32460033

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HSF2BP protects against acute liver injury by regulating HSF2/HSP70/MAPK signaling in mice.
      Title: HSF2BP protects against acute liver injury by regulating HSF2/HSP70/MAPK signaling in mice.
    2. A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1.
      Title: A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1.
    3. BRCA2 binds to the C-terminus of MEILB2, resulting in the formation of the BRCA2-MEILB2-BRME1 ternary complex.
      Title: The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells.
    4. HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis.
      Title: HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis.
    5. Naturally occurring elevated production of HSF2BP in tumors may be a source of cancer-promoting genomic instability and also a targetable vulnerability.
      Title: HSF2BP negatively regulates homologous recombination in DNA interstrand crosslink repair.
    6. HSF2BP may play a pivotal role in regulating BNC1 transcriptional activity and subcellular localization during spermatogenesis.
      Title: HSF2BP represses BNC1 transcriptional activity by sequestering BNC1 to the cytoplasm.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in double-strand break repair involved in meiotic recombination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in female meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male meiosis I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spermatogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    heat shock factor 2-binding protein
    Names
    meiotic localizer of BRCA2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028902.1 → NP_083178.1  heat shock factor 2-binding protein

      See identical proteins and their annotated locations for NP_083178.1

      Status: VALIDATED

      Source sequence(s)
      AK016553, DV650538
      Consensus CDS
      CCDS50056.1
      UniProtKB/Swiss-Prot
      Q9D4G2
      UniProtKB/TrEMBL
      A0A3T0ZJB3
      Related
      ENSMUSP00000002145.6, ENSMUST00000002145.12
      Conserved Domains (1) summary
      TIGR03319
      Location:12 → 122
      RNase_Y; ribonuclease Y

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      32163743..32253869 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525035.4 → XP_006525098.1  heat shock factor 2-binding protein isoform X1

      Conserved Domains (1) summary
      PRK12704
      Location:2 → 105
      PRK12704; phosphodiesterase; Provisional

    2. XM_030250120.1 → XP_030105980.1  heat shock factor 2-binding protein isoform X2

      UniProtKB/TrEMBL
      F6UJ67
      Related
      ENSMUSP00000115909.3, ENSMUST00000133308.3
      Conserved Domains (1) summary
      TIGR02169
      Location:12 → 123
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D4G2.1 GenPept UniProtKB/Swiss-Prot:Q9D4G2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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