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    Catsperg1 cation channel sperm associated auxiliary subunit gamma 1 [ Mus musculus (house mouse) ]

    Gene ID: 320225, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Catsperg1provided by MGI
    Official Full Name
    cation channel sperm associated auxiliary subunit gamma 1provided by MGI
    Primary source
    MGI:MGI:2443617
    See related
    Ensembl:ENSMUSG00000049676 AllianceGenome:MGI:2443617
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Catsperg; A230107C01Rik
    Summary
    Predicted to be located in membrane and sperm principal piece. Predicted to be integral component of membrane. Predicted to be part of CatSper complex. Predicted to be active in motile cilium. Orthologous to human CATSPERG (cation channel sperm associated auxiliary subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 64.0) and CNS E18 (RPKM 1.6) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 B1; 7 16.94 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28880957..28915013, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (29181532..29215589, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene gametogenetin Neighboring gene STARR-positive B cell enhancer ABC_E1337 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 Neighboring gene STARR-positive B cell enhancer ABC_E10433 Neighboring gene STARR-positive B cell enhancer ABC_E4913 Neighboring gene STARR-seq mESC enhancer starr_18461 Neighboring gene potassium inwardly-rectifying channel, subfamily K, member 6 Neighboring gene STARR-positive B cell enhancer ABC_E544 Neighboring gene Yip1 interacting factor homolog B (S. cerevisiae) Neighboring gene RIKEN cDNA 2200002D01 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel, single, transmembrane protein CATSPERG is associated with CATSPER1 channel protein. Wang H, et al. Biol Reprod, 2009 Sep. PMID 19516020, Free PMC Article
    2. A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. Chung JJ, et al. Nat Commun, 2011 Jan 11. PMID 21224844, Free PMC Article
    3. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    part_of CatSper complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm principal piece IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cation channel sperm-associated protein subunit gamma 1
    Names
    cation channel, sperm-associated, gamma 1
    catsper channel auxiliary subunit gamma 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164658.1 → NP_001158130.1  cation channel sperm-associated protein subunit gamma 1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AK133307, AV277263, BB633050
      Consensus CDS
      CCDS52170.1
      UniProtKB/Swiss-Prot
      E9Q355
      Related
      ENSMUSP00000045233.7, ENSMUST00000047846.13
      Conserved Domains (1) summary
      pfam15064
      Location:13 → 919
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    2. NM_001368407.1 → NP_001355336.1  cation channel sperm-associated protein subunit gamma 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC164564
      Consensus CDS
      CCDS90197.1
      UniProtKB/Swiss-Prot
      E9PW02, E9Q355, E9QAY8, Q3V0A1, Q8C9D6, Q8CAA4, Q8R5F0
      Conserved Domains (1) summary
      pfam15064
      Location:7 → 973
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      28880957..28915013 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540090.4 → XP_006540153.1  cation channel sperm-associated protein subunit gamma 1 isoform X15

      Conserved Domains (1) summary
      pfam15064
      Location:59 → 1025
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    2. XM_006540091.4 → XP_006540154.1  cation channel sperm-associated protein subunit gamma 1 isoform X16

      See identical proteins and their annotated locations for XP_006540154.1

      UniProtKB/Swiss-Prot
      E9PW02, E9Q355, E9QAY8, Q3V0A1, Q8C9D6, Q8CAA4, Q8R5F0
      Related
      ENSMUSP00000129837.2, ENSMUST00000169143.8
      Conserved Domains (1) summary
      pfam15064
      Location:7 → 973
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    3. XM_006540094.4 → XP_006540157.1  cation channel sperm-associated protein subunit gamma 1 isoform X19

      Conserved Domains (1) summary
      pfam15064
      Location:7 → 806
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    4. XM_006540080.2 → XP_006540143.1  cation channel sperm-associated protein subunit gamma 1 isoform X7

      Conserved Domains (2) summary
      pfam03157
      Location:150 → 677
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam15064
      Location:733 → 1646
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    5. XM_017322301.2 → XP_017177790.1  cation channel sperm-associated protein subunit gamma 1 isoform X2

      Conserved Domains (2) summary
      pfam03157
      Location:150 → 677
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam15064
      Location:733 → 1681
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    6. XM_006540083.2 → XP_006540146.1  cation channel sperm-associated protein subunit gamma 1 isoform X11

      Conserved Domains (2) summary
      pfam03157
      Location:150 → 677
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam15064
      Location:733 → 1523
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    7. XM_006540076.2 → XP_006540139.1  cation channel sperm-associated protein subunit gamma 1 isoform X3

      Conserved Domains (2) summary
      pfam03157
      Location:150 → 677
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam15064
      Location:733 → 1679
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    8. XM_030242677.1 → XP_030098537.1  cation channel sperm-associated protein subunit gamma 1 isoform X9

      Conserved Domains (2) summary
      pfam03157
      Location:150 → 677
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam15064
      Location:733 → 1610
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    9. XM_006540078.2 → XP_006540141.1  cation channel sperm-associated protein subunit gamma 1 isoform X5

      Conserved Domains (2) summary
      pfam03157
      Location:150 → 677
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam15064
      Location:733 → 1663
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    10. XM_006540081.3 → XP_006540144.1  cation channel sperm-associated protein subunit gamma 1 isoform X8

      Conserved Domains (2) summary
      pfam03157
      Location:150 → 677
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam15064
      Location:733 → 1669
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    11. XM_006540077.2 → XP_006540140.1  cation channel sperm-associated protein subunit gamma 1 isoform X4

      Conserved Domains (2) summary
      pfam03157
      Location:150 → 677
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam15064
      Location:733 → 1699
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    12. XM_006540074.2 → XP_006540137.1  cation channel sperm-associated protein subunit gamma 1 isoform X1

      Conserved Domains (2) summary
      pfam03157
      Location:150 → 677
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam15064
      Location:733 → 1699
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    13. XM_006540086.2 → XP_006540149.1  cation channel sperm-associated protein subunit gamma 1 isoform X13

      Conserved Domains (2) summary
      pfam03157
      Location:150 → 677
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam15064
      Location:782 → 1479
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    14. XM_006540085.2 → XP_006540148.1  cation channel sperm-associated protein subunit gamma 1 isoform X12

      Conserved Domains (2) summary
      pfam03157
      Location:150 → 677
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam15064
      Location:733 → 1514
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    15. XM_006540082.2 → XP_006540145.1  cation channel sperm-associated protein subunit gamma 1 isoform X10

      Conserved Domains (2) summary
      pfam03157
      Location:150 → 677
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam15064
      Location:733 → 1532
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    16. XM_006540079.3 → XP_006540142.1  cation channel sperm-associated protein subunit gamma 1 isoform X6

      Conserved Domains (2) summary
      pfam03157
      Location:150 → 677
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam15064
      Location:733 → 1646
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    17. XM_011250601.2 → XP_011248903.1  cation channel sperm-associated protein subunit gamma 1 isoform X14

      See identical proteins and their annotated locations for XP_011248903.1

      Conserved Domains (2) summary
      pfam03157
      Location:150 → 677
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam15064
      Location:733 → 1593
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    18. XM_011250600.2 → XP_011248902.1  cation channel sperm-associated protein subunit gamma 1 isoform X14

      See identical proteins and their annotated locations for XP_011248902.1

      Conserved Domains (2) summary
      pfam03157
      Location:150 → 677
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam15064
      Location:733 → 1593
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    19. XM_030242678.1 → XP_030098538.1  cation channel sperm-associated protein subunit gamma 1 isoform X18

      Conserved Domains (3) summary
      PRK12678
      Location:81 → 318
      PRK12678; transcription termination factor Rho; Provisional
      pfam08017
      Location:352 → 666
      Fibrinogen_BP; Fibrinogen binding protein
      pfam15064
      Location:733 → 964
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    20. XM_006540092.5 → XP_006540155.1  cation channel sperm-associated protein subunit gamma 1 isoform X17

      See identical proteins and their annotated locations for XP_006540155.1

      Conserved Domains (3) summary
      PRK12678
      Location:81 → 318
      PRK12678; transcription termination factor Rho; Provisional
      pfam08017
      Location:352 → 666
      Fibrinogen_BP; Fibrinogen binding protein
      pfam15064
      Location:733 → 956
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    RNA

    1. XR_003946491.1 RNA Sequence

    2. XR_003946492.1 RNA Sequence

    3. XR_003946493.1 RNA Sequence

    4. XR_001785574.3 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001039721.2: Suppressed sequence

      Description
      NM_001039721.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q355.1 GenPept UniProtKB/Swiss-Prot:E9Q355

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