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    Adgrl3 adhesion G protein-coupled receptor L3 [ Mus musculus (house mouse) ]

    Gene ID: 319387, updated on 12-May-2024

    Summary

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    Official Symbol
    Adgrl3provided by MGI
    Official Full Name
    adhesion G protein-coupled receptor L3provided by MGI
    Primary source
    MGI:MGI:2441950
    See related
    Ensembl:ENSMUSG00000037605 AllianceGenome:MGI:2441950
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LEC3; Lphn3; CIRL-3; Gm1379; mKIAA0768; 5430402I23Rik; D130075K09Rik
    Summary
    Enables calcium ion binding activity. Involved in several processes, including locomotion involved in locomotory behavior; nervous system development; and response to cocaine. Acts upstream of or within positive regulation of synapse assembly. Located in axon and cell-cell junction. Is integral component of plasma membrane. Is active in glutamatergic synapse. Is expressed in ductus deferens; epididymis; esophagus; and ileum. Used to study attention deficit hyperactivity disorder. Orthologous to human ADGRL3 (adhesion G protein-coupled receptor L3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 5.1), whole brain E14.5 (RPKM 4.6) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 D- E1; 5 42.62 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (81167600..81980556)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (81019085..81827825)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene mitochondrial carrier homolog 2 pseudogene Neighboring gene heat shock protein 1 (chaperonin) pseudogene Neighboring gene STARR-seq mESC enhancer starr_13499 Neighboring gene STARR-positive B cell enhancer mm9_chr5:81649196-81649497 Neighboring gene STARR-seq mESC enhancer starr_13500 Neighboring gene STARR-seq mESC enhancer starr_13501 Neighboring gene STARR-seq mESC enhancer starr_13503 Neighboring gene STARR-seq mESC enhancer starr_13504 Neighboring gene predicted gene, 46946 Neighboring gene STARR-seq mESC enhancer starr_13508 Neighboring gene STARR-seq mESC enhancer starr_13509 Neighboring gene STARR-seq mESC enhancer starr_13510 Neighboring gene RIKEN cDNA 1700031L13 gene Neighboring gene STARR-seq mESC enhancer starr_13513 Neighboring gene STARR-seq mESC enhancer starr_13514 Neighboring gene STARR-seq mESC enhancer starr_13515 Neighboring gene ribosomal protein L7, pseudogene 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Disentangling autoproteolytic cleavage from tethered agonist-dependent activation of the adhesion receptor ADGRL3. Perry-Hauser NA, et al. J Biol Chem, 2022 Dec. PMID 36244455, Free PMC Article
    2. Adhesion GPCR Latrophilin 3 regulates synaptic function of cone photoreceptors in a trans-synaptic manner. Wang Y, et al. Proc Natl Acad Sci U S A, 2021 Nov 9. PMID 34732574, Free PMC Article
    3. Dissociation of impulsivity and aggression in mice deficient for the ADHD risk gene Adgrl3: Evidence for dopamine transporter dysregulation. Mortimer N, et al. Neuropharmacology, 2019 Sep 15. PMID 30849401
    4. Involvement of the Adhesion GPCRs Latrophilins in the Regulation of Insulin Release. Röthe J, et al. Cell Rep, 2019 Feb 5. PMID 30726739
    5. Behavioral and transcriptomic profiling of mice null for Lphn3, a gene implicated in ADHD and addiction. Orsini CA, et al. Mol Genet Genomic Med, 2016 May. PMID 27247960, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Alternative splicing of latrophilin-3 controls synapse formation.
      Title: Alternative splicing of latrophilin-3 controls synapse formation.
    2. Disentangling autoproteolytic cleavage from tethered agonist-dependent activation of the adhesion receptor ADGRL3.
      Title: Disentangling autoproteolytic cleavage from tethered agonist-dependent activation of the adhesion receptor ADGRL3.
    3. Adhesion GPCR Latrophilin 3 regulates synaptic function of cone photoreceptors in a trans-synaptic manner.
      Title: Adhesion GPCR Latrophilin 3 regulates synaptic function of cone photoreceptors in a trans-synaptic manner.
    4. Latrophilin-2 and latrophilin-3 are redundantly essential for parallel-fiber synapse function in cerebellum.
      Title: Latrophilin-2 and latrophilin-3 are redundantly essential for parallel-fiber synapse function in cerebellum.
    5. Study further validates Adgrl3 constitutive knockout mice as an experimental model of attention deficit/hyperactivity disorder while providing neuroanatomical targets for future studies involving ADGRL3 modified models.
      Title: Dissociation of impulsivity and aggression in mice deficient for the ADHD risk gene Adgrl3: Evidence for dopamine transporter dysregulation.
    6. Latrophilin-3 pancreatic variants couple to Gi proteins reducing cAMP. Latrophilin-3 activation in pancreatic islets reduces insulin secretion.
      Title: Involvement of the Adhesion GPCRs Latrophilins in the Regulation of Insulin Release.
    7. Data show that Unc5 cell guidance receptor Unc5D controls Latrophilin3 (LPHN3)-FLRT protein FLRT2-mediated cell adhesion.
      Title: Super-complexes of adhesion GPCRs and neural guidance receptors.
    8. The crystal structure of the OLF/FLRT3 complex shows that LPHN3-OLF in the closed state binds with high affinity to the concave face of FLRT3-LRR with a combination of hydrophobic and charged residues.
      Title: Structural and Mechanistic Insights into the Latrophilin3-FLRT3 Complex that Mediates Glutamatergic Synapse Development.
    9. Null mutant Lphn3 mice had a hyperactive phenotype in the open field test, independent of sex, and were more sensitive to locomotor stimulation.
      Title: Initial characterization of mice null for Lphn3, a gene implicated in ADHD and addiction.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (5)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC99439

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-cell adhesion via plasma-membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion via plasma-membrane adhesion molecules IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell-cell adhesion via plasma-membrane adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in locomotion involved in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of postsynaptic specialization structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in maintenance of postsynaptic specialization structure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of synapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to cocaine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synapse assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synapse organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor L3
    Names
    G protein coupled receptor Lec3
    calcium-independent alpha-latrotoxin receptor homolog 3
    latrophilin-3
    lectomedin-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347367.2 → NP_001334296.1  adhesion G protein-coupled receptor L3 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC102517, AC104196, AC114425, AC114622, AC121837, AC122054, AC124825, AC155075
      Consensus CDS
      CCDS84891.1
      UniProtKB/TrEMBL
      D3Z3X6, D3Z4V0
      Related
      ENSMUSP00000113836.2, ENSMUST00000118442.8

    2. NM_001347368.2 → NP_001334297.1  adhesion G protein-coupled receptor L3 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC102517, AC104196, AC114425, AC121837, AC122054, AC124825, AC155075
      Consensus CDS
      CCDS84893.1
      UniProtKB/TrEMBL
      D3Z4V0, D3Z6H9
      Conserved Domains (7) summary
      smart00284
      Location:205 → 461
      OLF; Olfactomedin-like domains
      smart00303
      Location:882 → 934
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:563 → 627
      HormR; Domain present in hormone receptors
      cd16005
      Location:942 → 1199
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1199 → 1262
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:636 → 856
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    3. NM_001347369.2 → NP_001334298.1  adhesion G protein-coupled receptor L3 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC102517, AC104196, AC114425, AC114622, AC121837, AC122054, AC124825, AC155075
      Consensus CDS
      CCDS84894.1
      UniProtKB/TrEMBL
      K3W4M8
      Related
      ENSMUSP00000113600.2, ENSMUST00000122356.8

    4. NM_001347371.2 → NP_001334300.1  adhesion G protein-coupled receptor L3 isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AC102517, AC104196, AC114425, AC121837, AC122054, AC124825, AC155075
      Consensus CDS
      CCDS84895.1
      UniProtKB/TrEMBL
      D3Z593, D3Z634
      Related
      ENSMUSP00000113374.2, ENSMUST00000122037.8

    5. NM_001359826.1 → NP_001346755.1  adhesion G protein-coupled receptor L3 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC104196, AC121837, AC155075, AK147374
      UniProtKB/TrEMBL
      D3Z3G4
      Conserved Domains (6) summary
      smart00303
      Location:643 → 695
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:324 → 388
      HormR; Domain present in hormone receptors
      pfam02354
      Location:969 → 1298
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:397 → 617
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd16005
      Location:703 → 969
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      cl02549
      Location:1 → 222
      OLF; Olfactomedin-like domain

    6. NM_001359828.1 → NP_001346757.1  adhesion G protein-coupled receptor L3 isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      AC102517, AC104196, AC114425, AC114622, AC121837, AC122054, AC124825, AC155075
      UniProtKB/Swiss-Prot
      Q3UHI7, Q3UM79, Q504Z9, Q5HZJ6, Q80T56, Q80TS3
      UniProtKB/TrEMBL
      K3W4M8
      Conserved Domains (7) summary
      smart00284
      Location:205 → 461
      OLF; Olfactomedin-like domains
      smart00303
      Location:882 → 934
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:563 → 627
      HormR; Domain present in hormone receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1208 → 1537
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:636 → 856
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd16005
      Location:942 → 1208
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors

    7. NM_001359829.1 → NP_001346758.1  adhesion G protein-coupled receptor L3 isoform 8 precursor

      Status: VALIDATED

      Source sequence(s)
      AC102517, AC104196, AC114425, AC121837, AC122054, AC124825, AC155075
      UniProtKB/TrEMBL
      D3Z4V0
      Conserved Domains (8) summary
      smart00284
      Location:132 → 388
      OLF; Olfactomedin-like domains
      smart00303
      Location:809 → 861
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:490 → 554
      HormR; Domain present in hormone receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1126 → 1189
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:562 → 783
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:871 → 896
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:869 → 1126
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    8. NM_001359830.1 → NP_001346759.1  adhesion G protein-coupled receptor L3 isoform 9 precursor

      Status: VALIDATED

      Source sequence(s)
      AC102517, AC104196, AC114425, AC121837, AC122054, AC124825, AC155075
      UniProtKB/TrEMBL
      D3YWR3
      Conserved Domains (8) summary
      smart00284
      Location:205 → 461
      OLF; Olfactomedin-like domains
      smart00303
      Location:882 → 934
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:563 → 627
      HormR; Domain present in hormone receptors
      cd14964
      Location:945 → 969
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1208 → 1273
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:636 → 856
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl28897
      Location:942 → 1208
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    9. NM_001359831.1 → NP_001346760.1  adhesion G protein-coupled receptor L3 isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      AC102517, AC104196, AC114425, AC121837, AC122054, AC124825, AC155075
      UniProtKB/Swiss-Prot
      Q3UHI7, Q3UM79, Q504Z9, Q5HZJ6, Q80T56, Q80TS3
      UniProtKB/TrEMBL
      K3W4M8
      Conserved Domains (7) summary
      smart00284
      Location:205 → 461
      OLF; Olfactomedin-like domains
      smart00303
      Location:882 → 934
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:563 → 627
      HormR; Domain present in hormone receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1208 → 1537
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:636 → 856
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd16005
      Location:942 → 1208
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors

    10. NM_001359832.1 → NP_001346761.1  adhesion G protein-coupled receptor L3 isoform 10 precursor

      Status: VALIDATED

      Source sequence(s)
      AC102517, AC104196, AC114425, AC114622, AC121837, AC122054, AC124825, AC155075
      UniProtKB/TrEMBL
      K3W4M8
      Conserved Domains (7) summary
      smart00284
      Location:200 → 456
      OLF; Olfactomedin-like domains
      smart00303
      Location:877 → 929
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:558 → 622
      HormR; Domain present in hormone receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1194 → 1523
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:631 → 851
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd16005
      Location:937 → 1194
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors

    11. NM_001359833.1 → NP_001346762.1  adhesion G protein-coupled receptor L3 isoform 11 precursor

      Status: VALIDATED

      Source sequence(s)
      AC102517, AC104196, AC114425, AC121837, AC122054, AC124825, AC155075
      UniProtKB/TrEMBL
      D3Z3G4
      Conserved Domains (7) summary
      smart00284
      Location:137 → 393
      OLF; Olfactomedin-like domains
      smart00303
      Location:813 → 865
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:495 → 559
      HormR; Domain present in hormone receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1139 → 1468
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:568 → 788
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd16005
      Location:873 → 1139
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors

    12. NM_001359834.1 → NP_001346763.1  adhesion G protein-coupled receptor L3 isoform 12 precursor

      Status: VALIDATED

      Source sequence(s)
      AC102517, AC104196, AC114425, AC114622, AC121837, AC122054, AC124825, AC155075
      UniProtKB/TrEMBL
      D3Z4V0
      Conserved Domains (8) summary
      smart00284
      Location:200 → 456
      OLF; Olfactomedin-like domains
      smart00303
      Location:877 → 929
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:558 → 622
      HormR; Domain present in hormone receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1203 → 1266
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:631 → 851
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:940 → 964
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:937 → 1203
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    13. NM_198702.3 → NP_941991.1  adhesion G protein-coupled receptor L3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_941991.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC104196, AC114425, AC155075, BC088989
      Consensus CDS
      CCDS39122.1
      UniProtKB/TrEMBL
      K3W4M8
      Conserved Domains (7) summary
      smart00284
      Location:205 → 461
      OLF; Olfactomedin-like domains
      smart00303
      Location:882 → 934
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:563 → 627
      HormR; Domain present in hormone receptors
      cd16005
      Location:942 → 1208
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1208 → 1543
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:636 → 856
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      81167600..81980556
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249474.4 → XP_011247776.1  adhesion G protein-coupled receptor L3 isoform X27

      UniProtKB/TrEMBL
      D3YWR3
      Conserved Domains (8) summary
      smart00284
      Location:205 → 461
      OLF; Olfactomedin-like domains
      smart00303
      Location:882 → 934
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:563 → 627
      HormR; Domain present in hormone receptors
      cd14964
      Location:945 → 969
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1208 → 1273
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:636 → 856
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl28897
      Location:942 → 1208
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_017320921.3 → XP_017176410.1  adhesion G protein-coupled receptor L3 isoform X30

      UniProtKB/TrEMBL
      D3YWR3
      Conserved Domains (7) summary
      smart00284
      Location:205 → 461
      OLF; Olfactomedin-like domains
      smart00303
      Location:882 → 934
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:563 → 627
      HormR; Domain present in hormone receptors
      cd16005
      Location:942 → 1199
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1199 → 1264
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:636 → 856
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    3. XM_036165192.1 → XP_036021085.1  adhesion G protein-coupled receptor L3 isoform X36

      UniProtKB/TrEMBL
      D3YWR3
      Conserved Domains (7) summary
      smart00284
      Location:205 → 461
      OLF; Olfactomedin-like domains
      smart00303
      Location:869 → 921
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:563 → 627
      HormR; Domain present in hormone receptors
      cd16005
      Location:929 → 1186
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1186 → 1251
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:635 → 843
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    4. XM_036165186.1 → XP_036021079.1  adhesion G protein-coupled receptor L3 isoform X29

      UniProtKB/TrEMBL
      D3YWR3
      Conserved Domains (8) summary
      smart00284
      Location:200 → 456
      OLF; Olfactomedin-like domains
      smart00303
      Location:877 → 929
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:558 → 622
      HormR; Domain present in hormone receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1203 → 1268
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:630 → 851
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:939 → 964
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:937 → 1203
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    5. XM_036165189.1 → XP_036021082.1  adhesion G protein-coupled receptor L3 isoform X33

      UniProtKB/TrEMBL
      D3YWR3
      Conserved Domains (7) summary
      smart00284
      Location:200 → 456
      OLF; Olfactomedin-like domains
      smart00303
      Location:877 → 929
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:558 → 622
      HormR; Domain present in hormone receptors
      cd16005
      Location:937 → 1194
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1194 → 1259
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:630 → 851
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    6. XM_036165194.1 → XP_036021087.1  adhesion G protein-coupled receptor L3 isoform X38

      UniProtKB/TrEMBL
      D3YWR3
      Conserved Domains (7) summary
      smart00284
      Location:200 → 456
      OLF; Olfactomedin-like domains
      smart00303
      Location:864 → 916
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:558 → 622
      HormR; Domain present in hormone receptors
      cd16005
      Location:924 → 1181
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1181 → 1246
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:630 → 838
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    7. XM_030254567.2 → XP_030110427.1  adhesion G protein-coupled receptor L3 isoform X22

      UniProtKB/TrEMBL
      D3Z4V0, D3Z6H7
      Related
      ENSMUSP00000113249.2, ENSMUST00000120445.8
      Conserved Domains (8) summary
      smart00284
      Location:205 → 461
      OLF; Olfactomedin-like domains
      smart00303
      Location:882 → 934
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:563 → 627
      HormR; Domain present in hormone receptors
      cd14964
      Location:944 → 969
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1208 → 1315
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:636 → 856
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl28897
      Location:942 → 1208
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    8. XM_011249461.4 → XP_011247763.1  adhesion G protein-coupled receptor L3 isoform X1

      UniProtKB/TrEMBL
      D3Z5M6
      Conserved Domains (7) summary
      smart00284
      Location:205 → 461
      OLF; Olfactomedin-like domains
      smart00303
      Location:882 → 934
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:563 → 627
      HormR; Domain present in hormone receptors
      cd16005
      Location:942 → 1208
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1208 → 1586
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:636 → 856
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    9. XM_011249471.4 → XP_011247773.1  adhesion G protein-coupled receptor L3 isoform X24

      UniProtKB/TrEMBL
      D3Z4V0
      Related
      ENSMUSP00000112388.2, ENSMUST00000117407.8
      Conserved Domains (7) summary
      smart00284
      Location:205 → 461
      OLF; Olfactomedin-like domains
      smart00303
      Location:882 → 934
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:563 → 627
      HormR; Domain present in hormone receptors
      cd16005
      Location:942 → 1199
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1199 → 1306
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:636 → 856
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    10. XM_036165183.1 → XP_036021076.1  adhesion G protein-coupled receptor L3 isoform X23

      UniProtKB/TrEMBL
      D3Z4V0
      Conserved Domains (8) summary
      smart00284
      Location:200 → 456
      OLF; Olfactomedin-like domains
      smart00303
      Location:877 → 929
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:558 → 622
      HormR; Domain present in hormone receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1203 → 1310
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:630 → 851
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:939 → 964
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:937 → 1203
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    11. XM_036165184.1 → XP_036021077.1  adhesion G protein-coupled receptor L3 isoform X25

      UniProtKB/TrEMBL
      D3Z4V0
      Conserved Domains (7) summary
      smart00284
      Location:200 → 456
      OLF; Olfactomedin-like domains
      smart00303
      Location:877 → 929
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:558 → 622
      HormR; Domain present in hormone receptors
      cd16005
      Location:937 → 1194
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1194 → 1301
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:630 → 851
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    12. XM_011249465.4 → XP_011247767.1  adhesion G protein-coupled receptor L3 isoform X4

      See identical proteins and their annotated locations for XP_011247767.1

      UniProtKB/TrEMBL
      K3W4M8
      Related
      ENSMUSP00000072336.5, ENSMUST00000072521.11
      Conserved Domains (7) summary
      smart00284
      Location:205 → 461
      OLF; Olfactomedin-like domains
      smart00303
      Location:882 → 934
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:563 → 627
      HormR; Domain present in hormone receptors
      cd16005
      Location:942 → 1208
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1208 → 1543
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:636 → 856
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    13. XM_036165169.1 → XP_036021062.1  adhesion G protein-coupled receptor L3 isoform X3

      UniProtKB/TrEMBL
      D3Z4S7
      Related
      ENSMUSP00000113694.2, ENSMUST00000121641.8
      Conserved Domains (7) summary
      smart00284
      Location:205 → 461
      OLF; Olfactomedin-like domains
      smart00303
      Location:882 → 934
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:563 → 627
      HormR; Domain present in hormone receptors
      cd16005
      Location:942 → 1199
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1199 → 1577
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:635 → 856
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    14. XM_017320919.3 → XP_017176408.1  adhesion G protein-coupled receptor L3 isoform X26

      UniProtKB/TrEMBL
      D3Z4V0, D3Z6H9
      Related
      ENSMUSP00000113243.2, ENSMUST00000119385.8
      Conserved Domains (7) summary
      smart00284
      Location:205 → 461
      OLF; Olfactomedin-like domains
      smart00303
      Location:882 → 934
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:563 → 627
      HormR; Domain present in hormone receptors
      cd16005
      Location:942 → 1199
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1199 → 1262
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:636 → 856
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    15. XM_030254564.2 → XP_030110424.1  adhesion G protein-coupled receptor L3 isoform X6

      UniProtKB/TrEMBL
      D3YTW7, K3W4M8
      Related
      ENSMUSP00000112823.2, ENSMUST00000121707.8
      Conserved Domains (7) summary
      smart00284
      Location:205 → 461
      OLF; Olfactomedin-like domains
      smart00303
      Location:882 → 934
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:563 → 627
      HormR; Domain present in hormone receptors
      cd16005
      Location:942 → 1199
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1199 → 1534
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:636 → 856
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    16. XM_036165173.1 → XP_036021066.1  adhesion G protein-coupled receptor L3 isoform X9

      UniProtKB/TrEMBL
      K3W4M8
      Conserved Domains (7) summary
      smart00284
      Location:205 → 461
      OLF; Olfactomedin-like domains
      smart00303
      Location:869 → 921
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:563 → 627
      HormR; Domain present in hormone receptors
      cd16005
      Location:929 → 1195
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1195 → 1524
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:635 → 843
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    17. XM_036165187.1 → XP_036021080.1  adhesion G protein-coupled receptor L3 isoform X31

      UniProtKB/TrEMBL
      D3Z4V0
      Conserved Domains (7) summary
      smart00284
      Location:205 → 461
      OLF; Olfactomedin-like domains
      smart00303
      Location:869 → 921
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:563 → 627
      HormR; Domain present in hormone receptors
      cd16005
      Location:929 → 1186
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1186 → 1249
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:635 → 843
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    18. XM_011249469.4 → XP_011247771.1  adhesion G protein-coupled receptor L3 isoform X11

      UniProtKB/TrEMBL
      K3W4M8
      Conserved Domains (7) summary
      smart00284
      Location:205 → 461
      OLF; Olfactomedin-like domains
      smart00303
      Location:869 → 921
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:563 → 627
      HormR; Domain present in hormone receptors
      cd16005
      Location:929 → 1186
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1186 → 1515
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:636 → 843
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    19. XM_036165170.1 → XP_036021063.1  adhesion G protein-coupled receptor L3 isoform X5

      UniProtKB/TrEMBL
      K3W4M8
      Conserved Domains (7) summary
      smart00284
      Location:200 → 456
      OLF; Olfactomedin-like domains
      smart00303
      Location:877 → 929
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:558 → 622
      HormR; Domain present in hormone receptors
      cd16005
      Location:937 → 1203
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1203 → 1538
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:630 → 851
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    20. XM_036165171.1 → XP_036021064.1  adhesion G protein-coupled receptor L3 isoform X7

      UniProtKB/TrEMBL
      K3W4M8
      Conserved Domains (7) summary
      smart00284
      Location:200 → 456
      OLF; Olfactomedin-like domains
      smart00303
      Location:877 → 929
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:558 → 622
      HormR; Domain present in hormone receptors
      cd16005
      Location:937 → 1203
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1203 → 1532
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:630 → 851
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    21. XM_036165185.1 → XP_036021078.1  adhesion G protein-coupled receptor L3 isoform X28

      UniProtKB/TrEMBL
      D3Z4V0
      Conserved Domains (7) summary
      smart00284
      Location:200 → 456
      OLF; Olfactomedin-like domains
      smart00303
      Location:877 → 929
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:558 → 622
      HormR; Domain present in hormone receptors
      cd16005
      Location:937 → 1194
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1194 → 1257
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:630 → 851
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    22. XM_036165172.1 → XP_036021065.1  adhesion G protein-coupled receptor L3 isoform X8

      UniProtKB/TrEMBL
      K3W4M8
      Conserved Domains (7) summary
      smart00284
      Location:200 → 456
      OLF; Olfactomedin-like domains
      smart00303
      Location:877 → 929
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:558 → 622
      HormR; Domain present in hormone receptors
      cd16005
      Location:937 → 1194
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1194 → 1529
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:630 → 851
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    23. XM_036165174.1 → XP_036021067.1  adhesion G protein-coupled receptor L3 isoform X10

      UniProtKB/TrEMBL
      K3W4M8
      Conserved Domains (7) summary
      smart00284
      Location:200 → 456
      OLF; Olfactomedin-like domains
      smart00303
      Location:864 → 916
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:558 → 622
      HormR; Domain present in hormone receptors
      cd16005
      Location:924 → 1190
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1190 → 1519
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:630 → 838
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    24. XM_036165190.1 → XP_036021083.1  adhesion G protein-coupled receptor L3 isoform X34

      UniProtKB/TrEMBL
      D3Z4V0
      Conserved Domains (7) summary
      smart00284
      Location:200 → 456
      OLF; Olfactomedin-like domains
      smart00303
      Location:864 → 916
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:558 → 622
      HormR; Domain present in hormone receptors
      cd16005
      Location:924 → 1181
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1181 → 1244
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:630 → 838
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    25. XM_030254566.2 → XP_030110426.1  adhesion G protein-coupled receptor L3 isoform X12

      UniProtKB/TrEMBL
      K3W4M8
      Conserved Domains (7) summary
      smart00284
      Location:200 → 456
      OLF; Olfactomedin-like domains
      smart00303
      Location:864 → 916
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:558 → 622
      HormR; Domain present in hormone receptors
      cd16005
      Location:924 → 1181
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1181 → 1510
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:631 → 838
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    26. XM_036165168.1 → XP_036021061.1  adhesion G protein-coupled receptor L3 isoform X2

      UniProtKB/TrEMBL
      D3Z5M6
      Related
      ENSMUSP00000113482.2, ENSMUST00000120673.8
      Conserved Domains (7) summary
      smart00284
      Location:200 → 456
      OLF; Olfactomedin-like domains
      smart00303
      Location:877 → 929
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:558 → 622
      HormR; Domain present in hormone receptors
      cd16005
      Location:937 → 1203
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1203 → 1581
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:630 → 851
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    27. XM_036165200.1 → XP_036021093.1  adhesion G protein-coupled receptor L3 isoform X44

      UniProtKB/TrEMBL
      D3YWR3
      Conserved Domains (8) summary
      smart00284
      Location:137 → 393
      OLF; Olfactomedin-like domains
      smart00303
      Location:801 → 853
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:495 → 559
      HormR; Domain present in hormone receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1118 → 1183
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:567 → 775
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:863 → 888
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:861 → 1118
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    28. XM_036165199.1 → XP_036021092.1  adhesion G protein-coupled receptor L3 isoform X43

      UniProtKB/TrEMBL
      D3YWR3
      Conserved Domains (8) summary
      smart00284
      Location:132 → 388
      OLF; Olfactomedin-like domains
      smart00303
      Location:809 → 861
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:490 → 554
      HormR; Domain present in hormone receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1126 → 1191
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:562 → 783
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:871 → 896
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:869 → 1126
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    29. XM_036165201.1 → XP_036021094.1  adhesion G protein-coupled receptor L3 isoform X45

      UniProtKB/TrEMBL
      D3YWR3
      Conserved Domains (8) summary
      smart00284
      Location:132 → 388
      OLF; Olfactomedin-like domains
      smart00303
      Location:796 → 848
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:490 → 554
      HormR; Domain present in hormone receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1113 → 1178
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:562 → 770
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:858 → 883
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:856 → 1113
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    30. XM_036165188.1 → XP_036021081.1  adhesion G protein-coupled receptor L3 isoform X32

      UniProtKB/TrEMBL
      D3YWB1, D3Z4V0
      Related
      ENSMUSP00000112548.2, ENSMUST00000120292.8
      Conserved Domains (8) summary
      smart00284
      Location:137 → 393
      OLF; Olfactomedin-like domains
      smart00303
      Location:814 → 866
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:495 → 559
      HormR; Domain present in hormone receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1140 → 1247
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:567 → 788
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:876 → 901
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:874 → 1140
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    31. XM_036165191.1 → XP_036021084.1  adhesion G protein-coupled receptor L3 isoform X35

      UniProtKB/TrEMBL
      D3Z4V0
      Conserved Domains (8) summary
      smart00284
      Location:132 → 388
      OLF; Olfactomedin-like domains
      smart00303
      Location:809 → 861
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:490 → 554
      HormR; Domain present in hormone receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1135 → 1242
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:562 → 783
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:871 → 896
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:869 → 1135
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    32. XM_036165193.1 → XP_036021086.1  adhesion G protein-coupled receptor L3 isoform X37

      UniProtKB/TrEMBL
      D3Z4V0
      Conserved Domains (8) summary
      smart00284
      Location:132 → 388
      OLF; Olfactomedin-like domains
      smart00303
      Location:809 → 861
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:490 → 554
      HormR; Domain present in hormone receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1126 → 1233
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:562 → 783
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:871 → 896
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:869 → 1126
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    33. XM_036165195.1 → XP_036021088.1  adhesion G protein-coupled receptor L3 isoform X39

      UniProtKB/TrEMBL
      D3Z4V0, D3Z6J2
      Related
      ENSMUSP00000113208.2, ENSMUST00000120128.8
      Conserved Domains (8) summary
      smart00284
      Location:137 → 393
      OLF; Olfactomedin-like domains
      smart00303
      Location:814 → 866
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:495 → 559
      HormR; Domain present in hormone receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1140 → 1203
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:567 → 788
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:876 → 901
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:874 → 1140
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    34. XM_036165175.1 → XP_036021068.1  adhesion G protein-coupled receptor L3 isoform X13

      UniProtKB/TrEMBL
      D3Z3G4
      Conserved Domains (7) summary
      smart00284
      Location:137 → 393
      OLF; Olfactomedin-like domains
      smart00303
      Location:814 → 866
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:495 → 559
      HormR; Domain present in hormone receptors
      cd16005
      Location:874 → 1140
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1140 → 1475
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:567 → 788
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    35. XM_036165177.1 → XP_036021070.1  adhesion G protein-coupled receptor L3 isoform X15

      UniProtKB/TrEMBL
      D3Z3G4
      Related
      ENSMUSP00000113950.2, ENSMUST00000117985.8
      Conserved Domains (7) summary
      smart00284
      Location:137 → 393
      OLF; Olfactomedin-like domains
      smart00303
      Location:814 → 866
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:495 → 559
      HormR; Domain present in hormone receptors
      cd16005
      Location:874 → 1140
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1140 → 1469
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:567 → 788
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    36. XM_036165197.1 → XP_036021090.1  adhesion G protein-coupled receptor L3 isoform X41

      UniProtKB/TrEMBL
      D3YU23, D3Z4V0
      Related
      ENSMUSP00000112731.2, ENSMUST00000118078.8
      Conserved Domains (8) summary
      smart00284
      Location:137 → 393
      OLF; Olfactomedin-like domains
      smart00303
      Location:814 → 866
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:495 → 559
      HormR; Domain present in hormone receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1131 → 1194
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:567 → 788
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:876 → 901
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:874 → 1131
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    37. XM_036165178.1 → XP_036021071.1  adhesion G protein-coupled receptor L3 isoform X16

      UniProtKB/TrEMBL
      D3Z593
      Related
      ENSMUSP00000113534.2, ENSMUST00000118034.8
      Conserved Domains (7) summary
      smart00284
      Location:137 → 393
      OLF; Olfactomedin-like domains
      smart00303
      Location:814 → 866
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:495 → 559
      HormR; Domain present in hormone receptors
      cd16005
      Location:874 → 1131
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1131 → 1466
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:567 → 788
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    38. XM_036165196.1 → XP_036021089.1  adhesion G protein-coupled receptor L3 isoform X40

      UniProtKB/TrEMBL
      D3Z4V0
      Conserved Domains (8) summary
      smart00284
      Location:132 → 388
      OLF; Olfactomedin-like domains
      smart00303
      Location:809 → 861
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:490 → 554
      HormR; Domain present in hormone receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1135 → 1198
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:562 → 783
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:871 → 896
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:869 → 1135
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    39. XM_036165176.1 → XP_036021069.1  adhesion G protein-coupled receptor L3 isoform X14

      UniProtKB/TrEMBL
      D3Z3G4
      Conserved Domains (7) summary
      smart00284
      Location:132 → 388
      OLF; Olfactomedin-like domains
      smart00303
      Location:809 → 861
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:490 → 554
      HormR; Domain present in hormone receptors
      cd16005
      Location:869 → 1135
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1135 → 1470
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:562 → 783
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    40. XM_017320915.3 → XP_017176404.1  adhesion G protein-coupled receptor L3 isoform X17

      UniProtKB/TrEMBL
      D3Z3G4
      Conserved Domains (8) summary
      smart00284
      Location:132 → 388
      OLF; Olfactomedin-like domains
      smart00303
      Location:809 → 861
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:490 → 554
      HormR; Domain present in hormone receptors
      cd14964
      Location:871 → 896
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1135 → 1464
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:563 → 783
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl28897
      Location:869 → 1135
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    41. XM_036165198.1 → XP_036021091.1  adhesion G protein-coupled receptor L3 isoform X42

      UniProtKB/TrEMBL
      D3Z4V0
      Conserved Domains (8) summary
      smart00284
      Location:132 → 388
      OLF; Olfactomedin-like domains
      smart00303
      Location:809 → 861
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:490 → 554
      HormR; Domain present in hormone receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1126 → 1189
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:562 → 783
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:871 → 896
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:869 → 1126
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    42. XM_036165179.1 → XP_036021072.1  adhesion G protein-coupled receptor L3 isoform X18

      UniProtKB/TrEMBL
      D3Z593
      Conserved Domains (7) summary
      smart00284
      Location:132 → 388
      OLF; Olfactomedin-like domains
      smart00303
      Location:809 → 861
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:490 → 554
      HormR; Domain present in hormone receptors
      cd16005
      Location:869 → 1126
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1126 → 1461
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:562 → 783
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    43. XM_036165180.1 → XP_036021073.1  adhesion G protein-coupled receptor L3 isoform X19

      UniProtKB/TrEMBL
      D3Z593
      Conserved Domains (7) summary
      smart00284
      Location:132 → 388
      OLF; Olfactomedin-like domains
      smart00303
      Location:809 → 861
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:490 → 554
      HormR; Domain present in hormone receptors
      cd16005
      Location:869 → 1126
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1126 → 1455
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:562 → 783
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    44. XM_036165181.1 → XP_036021074.1  adhesion G protein-coupled receptor L3 isoform X20

      UniProtKB/TrEMBL
      D3Z3G4
      Conserved Domains (8) summary
      smart00284
      Location:132 → 388
      OLF; Olfactomedin-like domains
      smart00303
      Location:796 → 848
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:490 → 554
      HormR; Domain present in hormone receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1122 → 1451
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:562 → 770
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:858 → 883
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:856 → 1122
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    45. XM_036165182.1 → XP_036021075.1  adhesion G protein-coupled receptor L3 isoform X21

      UniProtKB/TrEMBL
      D3Z593
      Conserved Domains (7) summary
      smart00284
      Location:132 → 388
      OLF; Olfactomedin-like domains
      smart00303
      Location:796 → 848
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:490 → 554
      HormR; Domain present in hormone receptors
      cd16005
      Location:856 → 1113
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:43 → 123
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1113 → 1442
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:562 → 770
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80TS3.3 GenPept UniProtKB/Swiss-Prot:Q80TS3

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