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    Ttc14 tetratricopeptide repeat domain 14 [ Mus musculus (house mouse) ]

    Gene ID: 67120, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Ttc14provided by MGI
    Official Full Name
    tetratricopeptide repeat domain 14provided by MGI
    Primary source
    MGI:MGI:1914370
    See related
    Ensembl:ENSMUSG00000027677 AllianceGenome:MGI:1914370
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    cI-44; mKIAA1980; 2700016E08Rik; 4930434D01Rik; 4931403I22Rik; 4933402I15Rik
    Summary
    Predicted to enable nucleic acid binding activity. Orthologous to human TTC14 (tetratricopeptide repeat domain 14). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 13.0), cortex adult (RPKM 11.9) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 A3; 3 16.32 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (33853923..33869009)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (33799798..33814860)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42203 Neighboring gene heat shock protein 1 (chaperonin) pseudogene Neighboring gene coiled-coil domain containing 39 Neighboring gene STARR-seq mESC enhancer starr_07362 Neighboring gene predicted gene, 42204 Neighboring gene STARR-positive B cell enhancer ABC_E11180 Neighboring gene predicted gene, 23175

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of cAMP analogue inducible genes in RAW264 macrophages. Takahashi Y, et al. Biochim Biophys Acta, 2000 Jul 24. PMID 11004510
    2. Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics. Lamberti A, et al. Biochimie, 2011 Oct. PMID 21689717
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1980

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    tetratricopeptide repeat protein 14
    Names
    TPR repeat protein 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290500.2 → NP_001277429.1  tetratricopeptide repeat protein 14 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AC154395
      Consensus CDS
      CCDS71232.1
      UniProtKB/Swiss-Prot
      G3X9T5, Q69Z51, Q8BRX6, Q8CD24, Q8CDF8, Q8R3Q9, Q9CSP9
      UniProtKB/TrEMBL
      E9PXW3
      Related
      ENSMUSP00000112450.4, ENSMUST00000117915.8
      Conserved Domains (4) summary
      smart00316
      Location:123 → 206
      S1; Ribosomal protein S1-like RNA-binding domain
      sd00006
      Location:254 → 282
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:288 → 321
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:254 → 319
      TPR_11; TPR repeat

    2. NM_001290502.2 → NP_001277431.1  tetratricopeptide repeat protein 14 isoform d

      See identical proteins and their annotated locations for NP_001277431.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in both UTRs, uses an alternate splice site in the 5' coding region and an alternate 3' terminal exon. These difference cause translation initiation at an alternate start codon compared to variant 1. The encoded isoform (d) is shorter and has novel N- and C-termini compared to isoform a.
      Source sequence(s)
      AC154395
      Consensus CDS
      CCDS79895.1
      UniProtKB/TrEMBL
      A0A0G2JGX7
      Related
      ENSMUSP00000143738.2, ENSMUST00000200271.5
      Conserved Domains (4) summary
      smart00316
      Location:120 → 203
      S1; Ribosomal protein S1-like RNA-binding domain
      sd00006
      Location:303 → 331
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:337 → 370
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:303 → 368
      TPR_11; TPR repeat

    3. NM_001404037.1 → NP_001390966.1  tetratricopeptide repeat protein 14 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC154395

    4. NM_001404038.1 → NP_001390967.1  tetratricopeptide repeat protein 14 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC154395

    5. NM_001404039.1 → NP_001390968.1  tetratricopeptide repeat protein 14 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC154395
      Related
      ENSMUSP00000142863.2, ENSMUST00000196369.2

    6. NM_001404040.1 → NP_001390969.1  tetratricopeptide repeat protein 14 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC154395

    7. NM_001404041.1 → NP_001390970.1  tetratricopeptide repeat protein 14 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC154395

    8. NM_001404042.1 → NP_001390971.1  tetratricopeptide repeat protein 14 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC154395

    9. NM_025978.5 → NP_080254.2  tetratricopeptide repeat protein 14 isoform b

      See identical proteins and their annotated locations for NP_080254.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate structure in the 3' UTR and 3' coding region compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC154395
      Consensus CDS
      CCDS17303.1
      UniProtKB/TrEMBL
      A0A0G2JE97, A6H6N9
      Related
      ENSMUSP00000096757.4, ENSMUST00000099153.10
      Conserved Domains (4) summary
      smart00316
      Location:123 → 206
      S1; Ribosomal protein S1-like RNA-binding domain
      sd00006
      Location:306 → 334
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:340 → 373
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:306 → 371
      TPR_11; TPR repeat

    10. NM_027619.5 → NP_081895.2  tetratricopeptide repeat protein 14 isoform a

      See identical proteins and their annotated locations for NP_081895.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform (a).
      Source sequence(s)
      AC154395
      Consensus CDS
      CCDS38410.1
      UniProtKB/Swiss-Prot
      G3X9T5, Q69Z51, Q8BRX6, Q8CD24, Q8CDF8, Q8R3Q9, Q9CSP9
      UniProtKB/TrEMBL
      A0A8V5I5B0
      Related
      ENSMUSP00000103845.5, ENSMUST00000108210.9
      Conserved Domains (4) summary
      smart00316
      Location:123 → 206
      S1; Ribosomal protein S1-like RNA-binding domain
      sd00006
      Location:306 → 334
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:340 → 373
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:306 → 371
      TPR_11; TPR repeat

    RNA

    1. NR_175794.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154395

    2. NR_175795.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154395

    3. NR_175796.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154395

    4. NR_175797.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154395

    5. NR_175798.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154395

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      33853923..33869009
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163240.1 → XP_036019133.1  tetratricopeptide repeat protein 14 isoform X7

      UniProtKB/TrEMBL
      A0A0G2JEX0, A0A0G2JF90
      Related
      ENSMUSP00000142935.2, ENSMUST00000199222.5
      Conserved Domains (3) summary
      smart00316
      Location:123 → 206
      S1; Ribosomal protein S1-like RNA-binding domain
      COG0457
      Location:289 → 430
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:306 → 334
      TPR; TPR repeat [structural motif]

    2. XM_006535522.4 → XP_006535585.1  tetratricopeptide repeat protein 14 isoform X1

      UniProtKB/Swiss-Prot
      G3X9T5, Q69Z51, Q8BRX6, Q8CD24, Q8CDF8, Q8R3Q9, Q9CSP9
      Conserved Domains (3) summary
      smart00316
      Location:154 → 237
      S1; Ribosomal protein S1-like RNA-binding domain
      COG0457
      Location:256 → 415
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:285 → 313
      TPR; TPR repeat [structural motif]

    3. XM_011249707.4 → XP_011248009.1  tetratricopeptide repeat protein 14 isoform X6

      UniProtKB/TrEMBL
      A0A0G2JF90
      Conserved Domains (3) summary
      smart00316
      Location:154 → 237
      S1; Ribosomal protein S1-like RNA-binding domain
      COG0457
      Location:320 → 461
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:337 → 365
      TPR; TPR repeat [structural motif]

    4. XM_011249706.4 → XP_011248008.1  tetratricopeptide repeat protein 14 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JF90
      Conserved Domains (3) summary
      smart00316
      Location:154 → 237
      S1; Ribosomal protein S1-like RNA-binding domain
      COG0457
      Location:320 → 473
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:337 → 365
      TPR; TPR repeat [structural motif]

    5. XM_036163238.1 → XP_036019131.1  tetratricopeptide repeat protein 14 isoform X3

      Conserved Domains (3) summary
      COG0457
      Location:75 → 222
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:92 → 120
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:102 → 140
      TPR_11; TPR repeat

    6. XM_030252768.2 → XP_030108628.1  tetratricopeptide repeat protein 14 isoform X4

      Conserved Domains (3) summary
      COG0457
      Location:11 → 170
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:40 → 68
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:50 → 88
      TPR_11; TPR repeat

    RNA

    1. XR_880651.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CSP9.3 GenPept UniProtKB/Swiss-Prot:Q9CSP9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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