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    Clasp2 CLIP associating protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 76499, updated on 12-May-2024

    Summary

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    Official Symbol
    Clasp2provided by MGI
    Official Full Name
    CLIP associating protein 2provided by MGI
    Primary source
    MGI:MGI:1923749
    See related
    Ensembl:ENSMUSG00000033392 AllianceGenome:MGI:1923749
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0627; CLASP2beta; 1500004F14Rik; 8030404L10Rik
    Summary
    Enables microtubule binding activity. Acts upstream of or within cell migration; establishment or maintenance of cell polarity; and negative regulation of microtubule depolymerization. Located in Golgi apparatus; cell leading edge; and microtubule cytoskeleton. Is expressed in early conceptus; nervous system; and oocyte. Orthologous to human CLASP2 (cytoplasmic linker associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 23.3), cerebellum adult (RPKM 19.0) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Clasp2 in Genome Data Viewer
    Location:
    9 F3; 9 64.06 cM
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (113567776..113748765)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (113740077..113919697)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25326 Neighboring gene programmed cell death 6 interacting protein Neighboring gene STARR-seq mESC enhancer starr_25327 Neighboring gene STARR-seq mESC enhancer starr_25328 Neighboring gene predicted gene, 38623 Neighboring gene STARR-seq mESC enhancer starr_25329 Neighboring gene STARR-seq mESC enhancer starr_25330 Neighboring gene predicted gene, 25059 Neighboring gene STARR-positive B cell enhancer ABC_E2309 Neighboring gene predicted gene, 39439 Neighboring gene upstream binding protein 1 Neighboring gene F-box and leucine-rich repeat protein 2 Neighboring gene predicted gene, 36035

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Distinct Functions for Mammalian CLASP1 and -2 During Neurite and Axon Elongation. Sayas CL, et al. Front Cell Neurosci, 2019. PMID 30787869, Free PMC Article
    2. The microtubule plus-end tracking protein CLASP2 is required for hematopoiesis and hematopoietic stem cell maintenance. Drabek K, et al. Cell Rep, 2012 Oct 25. PMID 23084744
    3. Clasp2 ensures mitotic fidelity and prevents differentiation of epidermal keratinocytes. Shahbazi MN, et al. J Cell Sci, 2017 Feb 15. PMID 28069833, Free PMC Article
    4. CLASP2 interacts with p120-catenin and governs microtubule dynamics at adherens junctions. Shahbazi MN, et al. J Cell Biol, 2013 Dec 23. PMID 24368809, Free PMC Article
    5. Microtubule plus-end tracking protein CLASP2 regulates neuronal polarity and synaptic function. Beffert U, et al. J Neurosci, 2012 Oct 3. PMID 23035100, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CLASP2 safeguards hematopoietic stem cell properties during mouse and fish development.
      Title: CLASP2 safeguards hematopoietic stem cell properties during mouse and fish development.
    2. Targeting the Microtubule EB1-CLASP2 Complex Modulates NaV1.5 at Intercalated Discs.
      Title: Targeting the Microtubule EB1-CLASP2 Complex Modulates Na(V)1.5 at Intercalated Discs.
    3. The novel protein SOGA1 was confirmed to colocalize with a microtubule-associated protein CLASP2 and with tubulin, which identifies SOGA1 as a new microtubule-associated protein.
      Title: Characterization of the CLASP2 Protein Interaction Network Identifies SOGA1 as a Microtubule-Associated Protein.
    4. data reveal that CLASP2 is an essential Reelin effector orchestrating cytoskeleton dynamics during brain development.
      Title: CLASP2 Links Reelin to the Cytoskeleton during Neocortical Development.
    5. These findings reveal a new role for Clasp2 in governing keratinocyte undifferentiated features.
      Title: Clasp2 ensures mitotic fidelity and prevents differentiation of epidermal keratinocytes.
    6. A transport system, organized by agrin through PI3 kinase, GSK3beta, CLASP2, and LL5beta, for precise delivery of acetylcholine receptor vesicles from subsynaptic nuclei to overlying synaptic membrane was identified at neuromuscular junction membrane.
      Title: CLASP2-dependent microtubule capture at the neuromuscular junction membrane requires LL5β and actin for focal delivery of acetylcholine receptor vesicles.
    7. the functional relationship between Abl and CLASP2 is conserved and provides a means to control the CLASP2 association with the cytoskeleton.
      Title: Abelson phosphorylation of CLASP2 modulates its association with microtubules and actin.
    8. The MT plus end-binding protein CLASP2 localizes to adherens junctions (AJs) via direct interaction with p120-catenin (p120) in primary basal mouse keratinocytes.
      Title: CLASP2 interacts with p120-catenin and governs microtubule dynamics at adherens junctions.
    9. CLASP2 is required for the proper attachment of fibroblasts, HSC-enriched cells, and platelets, indicating a general role for this protein in cell attachment.
      Title: The microtubule plus-end tracking protein CLASP2 is required for hematopoiesis and hematopoietic stem cell maintenance.
    10. CLASP2 directs the delivery of GLUT4 to cell cortex landing zones important for insulin action
      Title: Identification of a role for CLASP2 in insulin action.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dystroglycan binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule plus-end binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in establishment of cell polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in establishment of mitotic spindle localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within establishment or maintenance of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exit from mitosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within fibroblast migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule anchoring ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule nucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule organizing center organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of microtubule depolymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of wound healing, spreading of epidermal cells ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in platelet-derived growth factor receptor-beta signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of basement membrane assembly involved in embryonic body morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of extracellular matrix disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of gastrulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microtubule polymerization or depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microtubule-based process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle targeting ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axonal growth cone ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in basal cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basal cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell leading edge IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cortical microtubule plus-end ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CLIP-associating protein 2
    Names
    CLASP2alpha
    CLASP2gamma
    CLIP-associating protein CLASP2
    cytoplasmic linker-associated protein 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081960.1 → NP_001075429.1  CLIP-associating protein 2 isoform b

      See identical proteins and their annotated locations for NP_001075429.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 3. It encodes isoform b, which has a shorter and distinct N-terminus, compared to isoform c.
      Source sequence(s)
      AC107803, AK164326, BC117963
      Consensus CDS
      CCDS40787.1
      UniProtKB/Swiss-Prot
      Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
      UniProtKB/TrEMBL
      Q08EB6
      Related
      ENSMUSP00000130201.3, ENSMUST00000166734.10
      Conserved Domains (2) summary
      pfam12348
      Location:100 → 311
      CLASP_N; CLASP N terminal
      sd00044
      Location:1057 → 1079
      HEAT; HEAT repeat [structural motif]

    2. NM_001114347.1 → NP_001107819.1  CLIP-associating protein 2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
      Source sequence(s)
      AC107803, AC167246
      UniProtKB/Swiss-Prot
      Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
      Conserved Domains (2) summary
      pfam12348
      Location:327 → 538
      CLASP_N; CLASP N terminal
      sd00044
      Location:91 → 121
      HEAT; HEAT repeat [structural motif]

    3. NM_001286599.1 → NP_001273528.1  CLIP-associating protein 2 isoform d

      See identical proteins and their annotated locations for NP_001273528.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR, lacks a portion of the 3' coding region, and includes an alternate 3' terminal exon, compared to variant 3. It encodes isoform d, which has a shorter and distinct C-terminus, compared to isoform c.
      Source sequence(s)
      AI529145, AK005146, AK034560
      Consensus CDS
      CCDS90675.1
      UniProtKB/TrEMBL
      Q8BSE7
      Related
      ENSMUSP00000150741.2, ENSMUST00000216817.2
      Conserved Domains (2) summary
      sd00044
      Location:91 → 121
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:81 → 197
      CLASP_N; CLASP N terminal

    4. NM_001286600.1 → NP_001273529.1  CLIP-associating protein 2 isoform e

      See identical proteins and their annotated locations for NP_001273529.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' and 3' coding region, and initiates translation at an alternate start codon, compared to variant 3. It encodes isoform e, which is shorter and has a distinct N-terminus, compared to isoform c.
      Source sequence(s)
      AC107803, AK043551, AK148966
      Consensus CDS
      CCDS90676.1
      UniProtKB/Swiss-Prot
      Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
      UniProtKB/TrEMBL
      Q08EB5
      Related
      ENSMUSP00000149670.2, ENSMUST00000214522.2
      Conserved Domains (2) summary
      pfam12348
      Location:100 → 311
      CLASP_N; CLASP N terminal
      sd00044
      Location:1074 → 1096
      HEAT; HEAT repeat [structural motif]

    5. NM_001286601.1 → NP_001273530.1  CLIP-associating protein 2 isoform f

      See identical proteins and their annotated locations for NP_001273530.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' and 3' coding region, and initiates translation at an alternate start codon, compared to variant 3. It encodes isoform f, which is shorter and has a distinct N-terminus, compared to isoform c.
      Source sequence(s)
      AC107803, AK043551, AK164326
      UniProtKB/Swiss-Prot
      Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
      UniProtKB/TrEMBL
      A2RRR3
      Conserved Domains (2) summary
      pfam12348
      Location:2 → 113
      CLASP_N; CLASP N terminal
      sd00044
      Location:859 → 881
      HEAT; HEAT repeat [structural motif]

    6. NM_001286602.1 → NP_001273531.1  CLIP-associating protein 2 isoform g

      See identical proteins and their annotated locations for NP_001273531.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' and 3' coding region, and initiates translation at an alternate start codon, compared to variant 3. It encodes isoform g, which is shorter and has a distinct N-terminus, compared to isoform c.
      Source sequence(s)
      AC107803, AK043551, AK164326
      UniProtKB/TrEMBL
      B9EJA4, F7DCH5
      Related
      ENSMUSP00000128460.3, ENSMUST00000163895.3
      Conserved Domains (2) summary
      sd00044
      Location:1078 → 1100
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:99 → 311
      CLASP_N; CLASP N terminal

    7. NM_001286603.1 → NP_001273532.1  CLIP-associating protein 2 isoform h

      See identical proteins and their annotated locations for NP_001273532.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in both UTR's and the coding region but maintains the reading frame, compared to variant 3. This results in a protein (isoform h) that is shorter at both the N- and C-termini, compared to isoform c.
      Source sequence(s)
      AK005146, BC030468, CJ052159
      UniProtKB/Swiss-Prot
      Q8BRT1
      Related
      ENSMUST00000213966.2

    8. NM_029633.2 → NP_083909.2  CLIP-associating protein 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' and 3' coding region, and initiates translation at an alternate start codon, compared to variant 3. It encodes isoform a, which is shorter and has a distinct N-terminus, compared to isoform c.
      Source sequence(s)
      AC107803, AK164326, BC117963
      Consensus CDS
      CCDS52948.1
      UniProtKB/Swiss-Prot
      Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
      UniProtKB/TrEMBL
      E9Q8N5
      Related
      ENSMUSP00000107469.3, ENSMUST00000111838.10
      Conserved Domains (2) summary
      pfam12348
      Location:100 → 311
      CLASP_N; CLASP N terminal
      sd00044
      Location:1056 → 1078
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      113567776..113748765
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512384.5 → XP_006512447.1  CLIP-associating protein 2 isoform X1

      UniProtKB/TrEMBL
      F7DCH5
      Conserved Domains (4) summary
      sd00044
      Location:91 → 121
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:327 → 538
      CLASP_N; CLASP N terminal
      pfam15782
      Location:641 → 813
      GREB1; Gene regulated by oestrogen in breast cancer

    2. XM_006512385.5 → XP_006512448.1  CLIP-associating protein 2 isoform X2

      UniProtKB/TrEMBL
      F7DCH5
      Conserved Domains (4) summary
      sd00044
      Location:91 → 121
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:327 → 538
      CLASP_N; CLASP N terminal
      pfam15782
      Location:641 → 813
      GREB1; Gene regulated by oestrogen in breast cancer

    3. XM_006512387.5 → XP_006512450.1  CLIP-associating protein 2 isoform X4

      UniProtKB/TrEMBL
      F7DCH5
      Conserved Domains (4) summary
      sd00044
      Location:91 → 121
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:327 → 538
      CLASP_N; CLASP N terminal
      pfam15782
      Location:641 → 813
      GREB1; Gene regulated by oestrogen in breast cancer

    4. XM_036155382.1 → XP_036011275.1  CLIP-associating protein 2 isoform X7

      UniProtKB/TrEMBL
      F7DCH5
      Conserved Domains (3) summary
      sd00044
      Location:91 → 121
      HEAT; HEAT repeat [structural motif]
      pfam15402
      Location:687 → 809
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
      pfam12348
      Location:326 → 538
      CLASP_N; CLASP N terminal

    5. XM_006512391.5 → XP_006512454.1  CLIP-associating protein 2 isoform X11

      UniProtKB/Swiss-Prot
      Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
      Conserved Domains (4) summary
      PHA03307
      Location:652 → 803
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:91 → 121
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:327 → 538
      CLASP_N; CLASP N terminal

    6. XM_006512392.5 → XP_006512455.1  CLIP-associating protein 2 isoform X12

      UniProtKB/Swiss-Prot
      Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
      Conserved Domains (4) summary
      PHA03307
      Location:652 → 803
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:91 → 121
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:327 → 538
      CLASP_N; CLASP N terminal

    7. XM_030244700.2 → XP_030100560.1  CLIP-associating protein 2 isoform X17

      UniProtKB/Swiss-Prot
      Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
      Conserved Domains (4) summary
      PHA03307
      Location:652 → 803
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:91 → 121
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:327 → 538
      CLASP_N; CLASP N terminal

    8. XM_036155381.1 → XP_036011274.1  CLIP-associating protein 2 isoform X6

      UniProtKB/TrEMBL
      F7DCH5
      Conserved Domains (2) summary
      sd00044
      Location:91 → 121
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:326 → 538
      CLASP_N; CLASP N terminal

    9. XM_006512390.5 → XP_006512453.1  CLIP-associating protein 2 isoform X9

      UniProtKB/TrEMBL
      F7DCH5
      Conserved Domains (3) summary
      sd00044
      Location:91 → 121
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:327 → 538
      CLASP_N; CLASP N terminal

    10. XM_030244699.2 → XP_030100559.1  CLIP-associating protein 2 isoform X10

      UniProtKB/TrEMBL
      F7DCH5
      Conserved Domains (3) summary
      sd00044
      Location:91 → 121
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:327 → 538
      CLASP_N; CLASP N terminal

    11. XM_006512393.5 → XP_006512456.1  CLIP-associating protein 2 isoform X14

      UniProtKB/TrEMBL
      F7DCH5
      Conserved Domains (3) summary
      sd00044
      Location:91 → 121
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:327 → 538
      CLASP_N; CLASP N terminal

    12. XM_036155385.1 → XP_036011278.1  CLIP-associating protein 2 isoform X16

      UniProtKB/TrEMBL
      F7DCH5
      Conserved Domains (2) summary
      sd00044
      Location:91 → 121
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:326 → 538
      CLASP_N; CLASP N terminal

    13. XM_036155388.1 → XP_036011281.1  CLIP-associating protein 2 isoform X21

      UniProtKB/Swiss-Prot
      Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
      Conserved Domains (2) summary
      sd00044
      Location:91 → 121
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:326 → 538
      CLASP_N; CLASP N terminal

    14. XM_030244701.2 → XP_030100561.1  CLIP-associating protein 2 isoform X24

      UniProtKB/Swiss-Prot
      Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
      Conserved Domains (3) summary
      sd00044
      Location:91 → 121
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:327 → 538
      CLASP_N; CLASP N terminal

    15. XM_030244702.2 → XP_030100562.1  CLIP-associating protein 2 isoform X25

      UniProtKB/Swiss-Prot
      Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
      Conserved Domains (3) summary
      sd00044
      Location:91 → 121
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:327 → 538
      CLASP_N; CLASP N terminal

    16. XM_006512386.5 → XP_006512449.1  CLIP-associating protein 2 isoform X3

      UniProtKB/TrEMBL
      F7DCH5
      Conserved Domains (4) summary
      sd00044
      Location:91 → 121
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:327 → 538
      CLASP_N; CLASP N terminal
      pfam15402
      Location:681 → 803
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

    17. XM_036155383.1 → XP_036011276.1  CLIP-associating protein 2 isoform X13

      UniProtKB/TrEMBL
      F7DCH5
      Conserved Domains (2) summary
      sd00044
      Location:91 → 121
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:326 → 538
      CLASP_N; CLASP N terminal

    18. XM_036155389.1 → XP_036011282.1  CLIP-associating protein 2 isoform X23

      UniProtKB/Swiss-Prot
      Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
      Conserved Domains (2) summary
      sd00044
      Location:91 → 121
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:326 → 538
      CLASP_N; CLASP N terminal

    19. XM_006512388.5 → XP_006512451.1  CLIP-associating protein 2 isoform X5

      UniProtKB/TrEMBL
      F7DCH5
      Conserved Domains (4) summary
      PHA03307
      Location:630 → 788
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:91 → 121
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:327 → 538
      CLASP_N; CLASP N terminal

    20. XM_036155384.1 → XP_036011277.1  CLIP-associating protein 2 isoform X15

      UniProtKB/TrEMBL
      F7DCH5
      Conserved Domains (2) summary
      sd00044
      Location:91 → 121
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:326 → 538
      CLASP_N; CLASP N terminal

    21. XM_036155386.1 → XP_036011279.1  CLIP-associating protein 2 isoform X19

      UniProtKB/TrEMBL
      F7DCH5
      Conserved Domains (2) summary
      sd00044
      Location:91 → 121
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:326 → 538
      CLASP_N; CLASP N terminal

    22. XM_036155387.1 → XP_036011280.1  CLIP-associating protein 2 isoform X20

      UniProtKB/TrEMBL
      F7DCH5
      Conserved Domains (2) summary
      sd00044
      Location:91 → 121
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:326 → 538
      CLASP_N; CLASP N terminal

    23. XM_006512389.5 → XP_006512452.1  CLIP-associating protein 2 isoform X8

      UniProtKB/TrEMBL
      F7DCH5
      Conserved Domains (4) summary
      sd00044
      Location:91 → 121
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:327 → 538
      CLASP_N; CLASP N terminal
      pfam15402
      Location:673 → 795
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

    24. XM_006512394.5 → XP_006512457.1  CLIP-associating protein 2 isoform X18

      UniProtKB/TrEMBL
      F7DCH5
      Conserved Domains (3) summary
      sd00044
      Location:91 → 121
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:327 → 538
      CLASP_N; CLASP N terminal

    25. XM_006512397.5 → XP_006512460.1  CLIP-associating protein 2 isoform X22

      UniProtKB/TrEMBL
      F7DCH5
      Conserved Domains (3) summary
      sd00044
      Location:91 → 121
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:327 → 538
      CLASP_N; CLASP N terminal

    26. XM_030244703.2 → XP_030100563.1  CLIP-associating protein 2 isoform X26

      UniProtKB/Swiss-Prot
      Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
      Conserved Domains (3) summary
      sd00044
      Location:91 → 121
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:327 → 538
      CLASP_N; CLASP N terminal

    27. XM_030244704.2 → XP_030100564.1  CLIP-associating protein 2 isoform X27

      UniProtKB/Swiss-Prot
      Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
      Conserved Domains (3) summary
      sd00044
      Location:91 → 121
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:168 → 198
      HEAT; HEAT repeat
      pfam12348
      Location:327 → 538
      CLASP_N; CLASP N terminal

    28. XM_036155390.1 → XP_036011283.1  CLIP-associating protein 2 isoform X28

      UniProtKB/Swiss-Prot
      Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
      Conserved Domains (2) summary
      sd00044
      Location:91 → 121
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:326 → 538
      CLASP_N; CLASP N terminal

    29. XM_030244705.2 → XP_030100565.1  CLIP-associating protein 2 isoform X29

      UniProtKB/TrEMBL
      F7DCH5
      Conserved Domains (4) summary
      sd00044
      Location:1224 → 1246
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:69 → 99
      HEAT; HEAT repeat
      pfam12348
      Location:228 → 439
      CLASP_N; CLASP N terminal
      pfam15782
      Location:542 → 714
      GREB1; Gene regulated by oestrogen in breast cancer

    30. XM_030244707.2 → XP_030100567.1  CLIP-associating protein 2 isoform X30

      UniProtKB/TrEMBL
      F7DCH5
      Conserved Domains (2) summary
      sd00044
      Location:1106 → 1128
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:109 → 321
      CLASP_N; CLASP N terminal

    31. XM_036155391.1 → XP_036011284.1  CLIP-associating protein 2 isoform X30

      UniProtKB/TrEMBL
      F7DCH5
      Conserved Domains (2) summary
      sd00044
      Location:1106 → 1128
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:109 → 321
      CLASP_N; CLASP N terminal

    32. XM_006512396.3 → XP_006512459.1  CLIP-associating protein 2 isoform X32

      UniProtKB/TrEMBL
      F7DCH5
      Conserved Domains (3) summary
      sd00044
      Location:1090 → 1112
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:94 → 305
      CLASP_N; CLASP N terminal
      pfam15782
      Location:408 → 580
      GREB1; Gene regulated by oestrogen in breast cancer

    33. XM_036155394.1 → XP_036011287.1  CLIP-associating protein 2 isoform X35

      UniProtKB/TrEMBL
      F7DCH5
      Conserved Domains (2) summary
      sd00044
      Location:1072 → 1094
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:93 → 305
      CLASP_N; CLASP N terminal

    34. XM_036155399.1 → XP_036011292.1  CLIP-associating protein 2 isoform X40

      UniProtKB/Swiss-Prot
      Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
      Conserved Domains (2) summary
      sd00044
      Location:1043 → 1065
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:93 → 305
      CLASP_N; CLASP N terminal

    35. XM_036155396.1 → XP_036011289.1  CLIP-associating protein 2 isoform X37

      UniProtKB/TrEMBL
      F7DCH5
      Conserved Domains (2) summary
      sd00044
      Location:1056 → 1078
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:93 → 305
      CLASP_N; CLASP N terminal

    36. XM_036155401.1 → XP_036011294.1  CLIP-associating protein 2 isoform X42

      UniProtKB/Swiss-Prot
      Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
      Conserved Domains (2) summary
      sd00044
      Location:1035 → 1057
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:93 → 305
      CLASP_N; CLASP N terminal

    37. XM_036155392.1 → XP_036011285.1  CLIP-associating protein 2 isoform X33

      UniProtKB/TrEMBL
      F7DCH5
      Conserved Domains (2) summary
      sd00044
      Location:1076 → 1098
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:93 → 305
      CLASP_N; CLASP N terminal

    38. XM_036155395.1 → XP_036011288.1  CLIP-associating protein 2 isoform X36

      UniProtKB/TrEMBL
      F7DCH5
      Conserved Domains (2) summary
      sd00044
      Location:1058 → 1080
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:93 → 305
      CLASP_N; CLASP N terminal

    39. XM_036155398.1 → XP_036011291.1  CLIP-associating protein 2 isoform X39

      UniProtKB/TrEMBL
      F7DCH5
      Conserved Domains (2) summary
      sd00044
      Location:1050 → 1072
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:93 → 305
      CLASP_N; CLASP N terminal

    40. XM_036155402.1 → XP_036011295.1  CLIP-associating protein 2 isoform X43

      UniProtKB/Swiss-Prot
      Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
      Conserved Domains (2) summary
      sd00044
      Location:1029 → 1051
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:93 → 305
      CLASP_N; CLASP N terminal

    41. XM_006512395.5 → XP_006512458.1  CLIP-associating protein 2 isoform X31

      UniProtKB/TrEMBL
      F7DCH5
      Conserved Domains (3) summary
      sd00044
      Location:1096 → 1118
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:100 → 311
      CLASP_N; CLASP N terminal
      pfam15782
      Location:414 → 586
      GREB1; Gene regulated by oestrogen in breast cancer

    42. XM_036155393.1 → XP_036011286.1  CLIP-associating protein 2 isoform X34

      UniProtKB/Swiss-Prot
      Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
      Conserved Domains (3) summary
      PHA03307
      Location:425 → 576
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00044
      Location:1075 → 1097
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:99 → 311
      CLASP_N; CLASP N terminal

    43. XM_036155397.1 → XP_036011290.1  CLIP-associating protein 2 isoform X38

      UniProtKB/Swiss-Prot
      Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
      Conserved Domains (2) summary
      sd00044
      Location:1048 → 1070
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:99 → 311
      CLASP_N; CLASP N terminal

    44. XM_036155400.1 → XP_036011293.1  CLIP-associating protein 2 isoform X41

      UniProtKB/Swiss-Prot
      Q8BRT1, Q8CHE3, Q99JI3, Q9DB80
      Conserved Domains (2) summary
      sd00044
      Location:1034 → 1056
      HEAT; HEAT repeat [structural motif]
      pfam12348
      Location:99 → 311
      CLASP_N; CLASP N terminal

    RNA

    1. XR_379881.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BRT1.1 GenPept UniProtKB/Swiss-Prot:Q8BRT1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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