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    Ankrd28 ankyrin repeat domain 28 [ Mus musculus (house mouse) ]

    Gene ID: 105522, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ankrd28provided by MGI
    Official Full Name
    ankyrin repeat domain 28provided by MGI
    Primary source
    MGI:MGI:2145661
    See related
    Ensembl:ENSMUSG00000014496 AllianceGenome:MGI:2145661
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0379; E430019N21Rik
    Summary
    Predicted to be located in nucleus. Orthologous to human ANKRD28 (ankyrin repeat domain 28). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 5.4), CNS E14 (RPKM 4.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 B; 14 19.4 cM
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (31418687..31552374, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (31698768..31830567, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36317 Neighboring gene predicted gene, 57482 Neighboring gene STARR-seq mESC enhancer starr_36319 Neighboring gene STARR-positive B cell enhancer ABC_E11568 Neighboring gene 2-hydroxyacyl-CoA lyase 1 Neighboring gene STARR-positive B cell enhancer ABC_E7304 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:32483369-32483556 Neighboring gene biotinidase Neighboring gene predicted gene, 53840 Neighboring gene STARR-positive B cell enhancer ABC_E4102 Neighboring gene STARR-seq mESC enhancer starr_36323 Neighboring gene STARR-seq mESC enhancer starr_36326 Neighboring gene RIKEN cDNA D830044D21 gene Neighboring gene STARR-seq mESC enhancer starr_36327 Neighboring gene predicted gene, 36164 Neighboring gene predicted gene, 53172

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Isolation and mapping of novel mouse brain cDNA clones containing trinucleotide repeats, and demonstration of novel alleles in recombinant inbred strains. Chambers DM, et al. Genome Res, 1996 Aug. PMID 8858346
    2. Systematic identification of factors for provirus silencing in embryonic stem cells. Yang BX, et al. Cell, 2015 Sep 24. PMID 26365490, Free PMC Article
    3. Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation. Alvarez-Dominguez JR, et al. Blood, 2014 Jan 23. PMID 24200680, Free PMC Article
    4. Widespread and dynamic translational control of red blood cell development. Alvarez-Dominguez JR, et al. Blood, 2017 Feb 2. PMID 27899360, Free PMC Article
    5. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0379

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
    Names
    PITK
    PP6-ARS-A
    ankyrin repeat domain-containing protein 28
    phosphatase interactor targeting protein hnRNP K
    serine/threonine-protein phosphatase 6 regulatory subunit ARS-A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024604.3 → NP_001019775.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform 1

      See identical proteins and their annotated locations for NP_001019775.1

      Status: VALIDATED

      Source sequence(s)
      AC109509, AC113598, AC120375
      Consensus CDS
      CCDS36858.1
      UniProtKB/Swiss-Prot
      Q505D1
      Related
      ENSMUSP00000014640.8, ENSMUST00000014640.9
      Conserved Domains (5) summary
      cd00204
      Location:134 → 259
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00023
      Location:42 → 71
      Ank; Ankyrin repeat
      pfam12796
      Location:177 → 269
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:756 → 808
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:140 → 170
      ANK; ANK repeat [structural motif]

    2. NM_001402762.1 → NP_001389691.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC109509, AC120375
      UniProtKB/TrEMBL
      A0A2I3BQ07
      Related
      ENSMUSP00000153992.2, ENSMUST00000227863.2

    3. NM_001402763.1 → NP_001389692.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC109509, AC113598, AC120375

    4. NM_001402764.1 → NP_001389693.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC109509, AC120375
      UniProtKB/TrEMBL
      A0A2I3BQJ1

    5. NM_001402765.1 → NP_001389694.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC109509, AC120375
      UniProtKB/TrEMBL
      A0A2I3BQJ1
      Related
      ENSMUSP00000154197.2, ENSMUST00000227089.2

    6. NM_001402766.1 → NP_001389695.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC109509, AC120375
      UniProtKB/TrEMBL
      A0A2I3BQJ1

    RNA

    1. NR_175291.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC109509, AC113598, AC120375

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      31418687..31552374 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158365.1 → XP_036014258.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X3

      Conserved Domains (5) summary
      PHA02874
      Location:182 → 491
      PHA02874; ankyrin repeat protein; Provisional
      PHA03095
      Location:17 → 343
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:246 → 278
      ANK; ANK repeat [structural motif]
      pfam00023
      Location:555 → 585
      Ank; Ankyrin repeat
      pfam12796
      Location:455 → 548
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_011244886.1 → XP_011243188.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X3

      Conserved Domains (5) summary
      PHA02874
      Location:182 → 491
      PHA02874; ankyrin repeat protein; Provisional
      PHA03095
      Location:17 → 343
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:246 → 278
      ANK; ANK repeat [structural motif]
      pfam00023
      Location:555 → 585
      Ank; Ankyrin repeat
      pfam12796
      Location:455 → 548
      Ank_2; Ankyrin repeats (3 copies)

    3. XM_036158366.1 → XP_036014259.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X4

      Conserved Domains (3) summary
      PHA03095
      Location:52 → 340
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:170 → 200
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:306 → 394
      Ank_2; Ankyrin repeats (3 copies)

    RNA

    1. XR_004938361.1 RNA Sequence

    2. XR_004938360.1 RNA Sequence

    3. XR_383131.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q505D1.1 GenPept UniProtKB/Swiss-Prot:Q505D1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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