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    Adgrf3 adhesion G protein-coupled receptor F3 [ Mus musculus (house mouse) ]

    Gene ID: 381628, updated on 12-May-2024

    Summary

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    Official Symbol
    Adgrf3provided by MGI
    Official Full Name
    adhesion G protein-coupled receptor F3provided by MGI
    Primary source
    MGI:MGI:2685887
    See related
    Ensembl:ENSMUSG00000067642 AllianceGenome:MGI:2685887
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pgr23; Gm1041; Gpr113
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and cell surface receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in circumvallate papilla; testis; and tongue epithelium. Orthologous to human ADGRF3 (adhesion G protein-coupled receptor F3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 6.1) and genital fat pad adult (RPKM 0.3) See more
    Orthologs
    human all
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    Genomic context

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    See Adgrf3 in Genome Data Viewer
    Location:
    5 B1; 5 16.13 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (30398429..30410752, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30193431..30205754, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha Neighboring gene STARR-positive B cell enhancer ABC_E8045 Neighboring gene hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta Neighboring gene microRNA 1960 Neighboring gene STARR-positive B cell enhancer ABC_E1678 Neighboring gene predicted gene, 54326 Neighboring gene selenoprotein I Neighboring gene predicted gene 16288

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Two novel genes, Gpr113, which encodes a family 2 G-protein-coupled receptor, and Trcg1, are selectively expressed in taste receptor cells. LopezJimenez ND, et al. Genomics, 2005 Apr. PMID 15780750
    2. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Bjarnadóttir TK, et al. Genomics, 2004 Jul. PMID 15203201
    3. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Hamann J, et al. Pharmacol Rev, 2015. PMID 25713288, Free PMC Article
    4. The G protein-coupled receptor repertoires of human and mouse. Vassilatis DK, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12679517, Free PMC Article
    5. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression analyses indicate that Gpr113 expression is highly restricted to a subset of taste receptor cells.
      Title: Two novel genes, Gpr113, which encodes a family 2 G-protein-coupled receptor, and Trcg1, are selectively expressed in taste receptor cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G-protein coupled receptor F3
    Names
    G protein coupled receptor Gpr113
    G protein-coupled receptor 113
    G-protein coupled receptor PGR23
    probable G-protein coupled receptor 113

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014394.2 → NP_001014416.2  adhesion G-protein coupled receptor F3 precursor

      See identical proteins and their annotated locations for NP_001014416.2

      Status: VALIDATED

      Source sequence(s)
      AC158757, AY701869
      Consensus CDS
      CCDS51450.1
      UniProtKB/Swiss-Prot
      F8VPU1, Q58Y75, Q80T50
      Related
      ENSMUSP00000085440.6, ENSMUST00000088117.11
      Conserved Domains (3) summary
      smart00303
      Location:631 → 678
      GPS; G-protein-coupled receptor proteolytic site domain
      pfam02793
      Location:352 → 398
      HRM; Hormone receptor domain
      cl21561
      Location:688 → 934
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      30398429..30410752 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535737.4 → XP_006535800.1  adhesion G-protein coupled receptor F3 isoform X2

      Conserved Domains (4) summary
      cd14964
      Location:689 → 714
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam01825
      Location:635 → 678
      GPS; GPCR proteolysis site, GPS, motif
      pfam02793
      Location:352 → 398
      HRM; Hormone receptor domain
      cl28897
      Location:688 → 954
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_006535738.4 → XP_006535801.1  adhesion G-protein coupled receptor F3 isoform X3

      Conserved Domains (4) summary
      cd14964
      Location:458 → 483
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam01825
      Location:404 → 447
      GPS; GPCR proteolysis site, GPS, motif
      pfam02793
      Location:121 → 167
      HRM; Hormone receptor domain
      cl28897
      Location:457 → 723
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. XM_011249775.3 → XP_011248077.1  adhesion G-protein coupled receptor F3 isoform X4

      Conserved Domains (3) summary
      pfam01825
      Location:635 → 678
      GPS; GPCR proteolysis site, GPS, motif
      pfam02793
      Location:352 → 398
      HRM; Hormone receptor domain
      cl28897
      Location:694 → 718
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    4. XM_006535740.4 → XP_006535803.1  adhesion G-protein coupled receptor F3 isoform X5

      Conserved Domains (4) summary
      cd14964
      Location:386 → 411
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam01825
      Location:332 → 375
      GPS; GPCR proteolysis site, GPS, motif
      pfam02793
      Location:49 → 95
      HRM; Hormone receptor domain
      cl28897
      Location:385 → 651
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    5. XM_006535736.4 → XP_006535799.1  adhesion G-protein coupled receptor F3 isoform X1

      Conserved Domains (4) summary
      cd14964
      Location:689 → 714
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam01825
      Location:635 → 678
      GPS; GPCR proteolysis site, GPS, motif
      pfam02793
      Location:352 → 398
      HRM; Hormone receptor domain
      cl28897
      Location:688 → 954
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q58Y75.2 GenPept UniProtKB/Swiss-Prot:Q58Y75

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