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    Nsun7 NOL1/NOP2/Sun domain family, member 7 [ Mus musculus (house mouse) ]

    Gene ID: 70918, updated on 12-May-2024

    Summary

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    Official Symbol
    Nsun7provided by MGI
    Official Full Name
    NOL1/NOP2/Sun domain family, member 7provided by MGI
    Primary source
    MGI:MGI:1918168
    See related
    Ensembl:ENSMUSG00000029206 AllianceGenome:MGI:1918168
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4921525L17Rik
    Summary
    This gene encodes a member of the NOL1/NOP2/sun domain RNA methyltransferase family. Mice with a mutation in this gene exhibit male sterility due to impaired sperm motility. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]
    Expression
    Biased expression in testis adult (RPKM 9.7), frontal lobe adult (RPKM 1.4) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nsun7 in Genome Data Viewer
    Location:
    5 C3.1; 5 34.34 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (66417181..66457544)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (66259838..66299927)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700126H18 gene Neighboring gene predicted gene 43772 Neighboring gene STARR-seq mESC enhancer starr_13286 Neighboring gene STARR-seq mESC enhancer starr_13287 Neighboring gene STARR-seq mESC enhancer starr_13288 Neighboring gene predicted gene 15794 Neighboring gene STARR-seq mESC enhancer starr_13289 Neighboring gene STARR-seq mESC enhancer starr_13290 Neighboring gene STARR-seq mESC enhancer starr_13291 Neighboring gene amyloid beta precursor protein binding family B member 2 Neighboring gene STARR-seq mESC enhancer starr_13293 Neighboring gene STARR-seq mESC enhancer starr_13294 Neighboring gene predicted gene, 52775 Neighboring gene ubiquitin carboxy-terminal hydrolase L1, opposite strand Neighboring gene ubiquitin carboxy-terminal hydrolase L1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sperm motility defects and infertility in male mice with a mutation in Nsun7, a member of the Sun domain-containing family of putative RNA methyltransferases. Harris T, et al. Biol Reprod, 2007 Aug. PMID 17442852
    2. Expression of NOL1/NOP2/sun domain (Nsun) RNA methyltransferase family genes in early mouse embryogenesis. Chi L, et al. Gene Expr Patterns, 2013 Dec. PMID 23816522
    3. High resolution mapping and positional cloning of ENU-induced mutations in the Rw region of mouse chromosome 5. Ching YH, et al. BMC Genet, 2010 Nov 30. PMID 21118569, Free PMC Article
    4. Random mutagenesis of proximal mouse chromosome 5 uncovers predominantly embryonic lethal mutations. Wilson L, et al. Genome Res, 2005 Aug. PMID 16024820, Free PMC Article
    5. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sun domain containing protein Nsun7 mutant sperm exhibited depressed progressive motility associated with a rigid flagellar midpiece (but not principal piece) segment
      Title: Sperm motility defects and infertility in male mice with a mutation in Nsun7, a member of the Sun domain-containing family of putative RNA methyltransferases.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    General gene information

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    Homology

    Clone Names

    • MGC141647, MGC141648

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sperm mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative methyltransferase NSUN7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302833.2 → NP_001289762.1  putative methyltransferase NSUN7 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC131752
      Consensus CDS
      CCDS80290.1
      UniProtKB/Swiss-Prot
      Q14AW5, Q8BS48, Q9D5S9
      UniProtKB/TrEMBL
      E9QL78, E9QPI2
      Related
      ENSMUSP00000031109.5, ENSMUST00000031109.7
      Conserved Domains (1) summary
      cl17173
      Location:346 → 460
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. NM_001302834.2 → NP_001289763.1  putative methyltransferase NSUN7 isoform 2

      See identical proteins and their annotated locations for NP_001289763.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region and differs in the 3' exon structure, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC131752
      Consensus CDS
      CCDS80291.1
      UniProtKB/Swiss-Prot
      Q14AW5, Q8BS48, Q9D5S9
      Related
      ENSMUSP00000144498.2, ENSMUST00000202994.4
      Conserved Domains (1) summary
      cl17173
      Location:346 → 426
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. NM_001400914.1 → NP_001387843.1  putative methyltransferase NSUN7 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC131752

    4. NM_027602.3 → NP_081878.1  putative methyltransferase NSUN7 isoform 3

      See identical proteins and their annotated locations for NP_081878.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks the 5' terminal exon and uses an alternate splice site in the 3' terminal exon resulting in a frameshift, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC131752
      Consensus CDS
      CCDS19314.1
      UniProtKB/Swiss-Prot
      Q14AW5, Q8BS48, Q9D5S9
      UniProtKB/TrEMBL
      A0A0J9YV71
      Conserved Domains (1) summary
      COG0144
      Location:338 → 515
      RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      66417181..66457544
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321098.2 → XP_017176587.1  putative methyltransferase NSUN7 isoform X4

    2. XM_011240769.4 → XP_011239071.1  putative methyltransferase NSUN7 isoform X2

      See identical proteins and their annotated locations for XP_011239071.1

      UniProtKB/Swiss-Prot
      Q14AW5, Q8BS48, Q9D5S9
      UniProtKB/TrEMBL
      A0A0J9YV71
      Related
      ENSMUSP00000144520.2, ENSMUST00000201100.4
      Conserved Domains (1) summary
      COG0144
      Location:338 → 515
      RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

    3. XM_006504102.5 → XP_006504165.1  putative methyltransferase NSUN7 isoform X1

      See identical proteins and their annotated locations for XP_006504165.1

      UniProtKB/Swiss-Prot
      Q14AW5, Q8BS48, Q9D5S9
      Conserved Domains (1) summary
      COG0144
      Location:338 → 515
      RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

    4. XM_030254806.2 → XP_030110666.1  putative methyltransferase NSUN7 isoform X3

      UniProtKB/Swiss-Prot
      Q14AW5, Q8BS48, Q9D5S9
      Conserved Domains (1) summary
      COG0144
      Location:203 → 380
      RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

    5. XM_006504105.5 → XP_006504168.1  putative methyltransferase NSUN7 isoform X5

      See identical proteins and their annotated locations for XP_006504168.1

      Conserved Domains (1) summary
      COG0144
      Location:35 → 212
      RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

    6. XM_006504106.5 → XP_006504169.1  putative methyltransferase NSUN7 isoform X5

      See identical proteins and their annotated locations for XP_006504169.1

      Conserved Domains (1) summary
      COG0144
      Location:35 → 212
      RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

    RNA

    1. XR_004942559.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14AW5.2 GenPept UniProtKB/Swiss-Prot:Q14AW5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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