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    Fdx2 ferredoxin 2 [ Mus musculus (house mouse) ]

    Gene ID: 68165, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Fdx2provided by MGI
    Official Full Name
    ferredoxin 2provided by MGI
    Primary source
    MGI:MGI:1915415
    See related
    Ensembl:ENSMUSG00000079677 AllianceGenome:MGI:1915415
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fdx1l; B230118G17Rik
    Summary
    Predicted to enable 2 iron, 2 sulfur cluster binding activity; electron transfer activity; and metal ion binding activity. Located in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial myopathy. Orthologous to human FDX2 (ferredoxin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 38.6), cortex adult (RPKM 27.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fdx2 in Genome Data Viewer
    Location:
    9 A3; 9 7.7 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (20978808..20984827, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21067512..21073531, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26592 Neighboring gene intercellular adhesion molecule 5, telencephalin Neighboring gene zinc finger, GATA-like protein 1 Neighboring gene predicted gene, 38431 Neighboring gene ribonucleoprotein, PTB-binding 1 Neighboring gene microRNA 7082 Neighboring gene STARR-positive B cell enhancer ABC_E459 Neighboring gene tyrosine kinase 2 Neighboring gene STARR-positive B cell enhancer ABC_E1780

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery. Gakh O, et al. J Biol Chem, 2016 Sep 30. PMID 27519411, Free PMC Article
    2. Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex. Boniecki MT, et al. Nat Commun, 2017 Nov 3. PMID 29097656, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables electron transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables electron transfer activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in P450-containing electron transport chain IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in [2Fe-2S] cluster assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of [4Fe-4S] cluster assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in electron transport chain IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron-sulfur cluster assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of iron-sulfur cluster assembly complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ferredoxin-2, mitochondrial
    Names
    adrenodoxin-like protein, mitochondrial
    ferredoxin 1-like
    ferredoxin-1-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039824.3 → NP_001034913.1  ferredoxin-2, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001034913.1

      Status: VALIDATED

      Source sequence(s)
      AK020979, BC061189, BF318146
      Consensus CDS
      CCDS22892.1
      UniProtKB/Swiss-Prot
      Q6P8M0, Q9CPW2, Q9CV00
      Related
      ENSMUSP00000010348.6, ENSMUST00000010348.7
      Conserved Domains (1) summary
      PLN02593
      Location:59 → 174
      PLN02593; adrenodoxin-like ferredoxin protein

    RNA

    1. NR_157201.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BC061189, BF318146
      Related
      ENSMUST00000217150.2

    2. NR_157202.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163637

    3. NR_157203.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163637

    4. NR_157204.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163637

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      20978808..20984827 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CPW2.1 GenPept UniProtKB/Swiss-Prot:Q9CPW2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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