Ces3a carboxylesterase 3A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ces3aprovided by MGI
Official Full Name: carboxylesterase 3Aprovided by MGI
Primary source: MGI:MGI:102773
See related: Ensembl:ENSMUSG00000069922 AllianceGenome:MGI:102773
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ces3; Es31; Ces31
Summary: Predicted to enable methyl indole-3-acetate esterase activity. Predicted to be located in endoplasmic reticulum. Orthologous to human CES3 (carboxylesterase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward liver adult (RPKM 311.9) See more
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Genomic context

Location:: 8 D3; 8 53.04 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (105775208..105788560)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (105048576..105061928)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

activation of Ces3 contributes in the browning of white adipocytes, and maintains a balance in lipid metabolism, which could be a potential strategy in fighting against obesity
Title: Novel regulatory roles of carboxylesterase 3 in lipid metabolism and browning in 3T3-L1 white adipocytes.
Study highlights a lipolytic signaling induced by Ces3 as a unique process to regulate thermogenesis in adipose tissue.
Title: A Unique Role of Carboxylesterase 3 (Ces3) in β-Adrenergic Signaling-Stimulated Thermogenesis.
This carboxylesterase proetin is linked to obesity and diabetes in mice
Title: Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes.
Hepatic Ces3 modulates the hydrolysis of lipoprotein-delivered cholesterol esters and thereby regulates free cholesterol and bile acid secretion into the feces.
Title: Liver-specific cholesteryl ester hydrolase deficiency attenuates sterol elimination in the feces and increases atherosclerosis in ldlr-/- mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carboxylesterase activity	IEA Inferred from Electronic Annotation more info
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: carboxylesterase 3A

Names: Es-male carboxylesterase; esterase 31; liver carboxylesterase 31

NP_001158153.1

EC 3.1.1.1

NP_941074.1

EC 3.1.1.1

XP_011246729.1

EC 3.1.1.1

XP_030099511.1

EC 3.1.1.1

XP_030099512.1

EC 3.1.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164681.1 → NP_001158153.1 carboxylesterase 3A isoform 2 precursor

See identical proteins and their annotated locations for NP_001158153.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.

Source sequence(s)

AC164311, BC061004, CB952677

Consensus CDS

CCDS52652.1

UniProtKB/Swiss-Prot

Q63880

Related

ENSMUSP00000090911.4, ENSMUST00000093223.5

Conserved Domains (2) summary

COG0657
Location:75 → 245

Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

pfam00135
Location:36 → 500

COesterase; Carboxylesterase family
NM_198672.1 → NP_941074.1 carboxylesterase 3A isoform 1 precursor

See identical proteins and their annotated locations for NP_941074.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC164311, AK138932, CB952677

Consensus CDS

CCDS52651.1

UniProtKB/Swiss-Prot

Q3UEJ0, Q3UU08, Q63880, Q6P8Z0, Q6PG74, Q810S9

Related

ENSMUSP00000090910.6, ENSMUST00000093222.13

Conserved Domains (2) summary

COG0657
Location:75 → 245

Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

pfam00135
Location:36 → 547

COesterase; Carboxylesterase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

105775208..105788560

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011248427.3 → XP_011246729.1 carboxylesterase 3A isoform X1

Conserved Domains (1) summary

pfam00135
Location:37 → 507

COesterase; Carboxylesterase family
XM_030243651.1 → XP_030099511.1 carboxylesterase 3A isoform X2

Conserved Domains (1) summary

cl21494
Location:1 → 302

Abhydrolase; alpha/beta hydrolases
XM_030243652.1 → XP_030099512.1 carboxylesterase 3A isoform X3

Conserved Domains (1) summary

cl21494
Location:1 → 255

Abhydrolase; alpha/beta hydrolases