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    PRR15 proline rich 15 [ Homo sapiens (human) ]

    Gene ID: 222171, updated on 17-Jun-2024

    Summary

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    Official Symbol
    PRR15provided by HGNC
    Official Full Name
    proline rich 15provided by HGNC
    Primary source
    HGNC:HGNC:22310
    See related
    Ensembl:ENSG00000176532 MIM:618344; AllianceGenome:HGNC:22310
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Biased expression in colon (RPKM 29.0), small intestine (RPKM 15.6) and 6 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PRR15 in Genome Data Viewer
    Location:
    7p14.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (29563835..29567295)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (29701617..29705075)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (29603451..29606911)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene chimerin 2 Neighboring gene Nanog homeobox pseudogene 4 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr7:29327971-29328748 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29343002-29343502 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29343503-29344003 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:29349448-29350016 Neighboring gene NANOG hESC enhancer GRCh37_chr7:29364906-29365431 Neighboring gene MPRA-validated peak6458 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29414107-29414613 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29456733-29457232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29456231-29456732 Neighboring gene PRR15 divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:29605074-29605937 Neighboring gene GTF3C6 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 12919 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:29688411-29689013 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:29689014-29689615 Neighboring gene TMSB4X pseudogene 3 Neighboring gene uncharacterized LOC646762 Neighboring gene microRNA 550a-3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Effect of proline rich 15-deficiency on trophoblast viability and survival. Gates KC, et al. PLoS One, 2017. PMID 28380025, Free PMC Article
    2. Expression analysis of proline rich 15 (Prr15) in mouse and human gastrointestinal tumors. Meunier D, et al. Mol Carcinog, 2011 Jan. PMID 21061267
    3. PRR15 deficiency facilitates malignant progression by mediating PI3K/Akt signaling and predicts clinical prognosis in triple-negative rather than non-triple-negative breast cancer. Guo F, et al. Cell Death Dis, 2023 Apr 18. PMID 37072408, Free PMC Article
    4. The involvement of proline-rich 15 in early conceptus development in sheep. Purcell SH, et al. Biol Reprod, 2009 Dec. PMID 19605793, Free PMC Article
    5. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. Teixeira FR, et al. J Biol Chem, 2013 Sep 27. PMID 23940030, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PRR15 deficiency facilitates malignant progression by mediating PI3K/Akt signaling and predicts clinical prognosis in triple-negative rather than non-triple-negative breast cancer.
      Title: PRR15 deficiency facilitates malignant progression by mediating PI3K/Akt signaling and predicts clinical prognosis in triple-negative rather than non-triple-negative breast cancer.
    2. enhances trophoblast viability and survival during early implantation and placentation
      Title: Effect of proline rich 15-deficiency on trophoblast viability and survival.
    3. Proline-rich 15 is required for conceptus elongation and survival during early ovine pregnancy.
      Title: The involvement of proline-rich 15 in early conceptus development in sheep.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proline-rich protein 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001329996.2 → NP_001316925.1  proline-rich protein 15

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AC007255
      Consensus CDS
      CCDS5421.1
      UniProtKB/Swiss-Prot
      Q8IV56
      UniProtKB/TrEMBL
      A4D1A1
      Conserved Domains (1) summary
      pfam15321
      Location:13 → 109
      ATAD4; ATPase family AAA domain containing 4

    2. NM_001329997.1 → NP_001316926.1  proline-rich protein 15

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AC007255
      Consensus CDS
      CCDS5421.1
      UniProtKB/Swiss-Prot
      Q8IV56
      UniProtKB/TrEMBL
      A4D1A1
      Conserved Domains (1) summary
      pfam15321
      Location:13 → 109
      ATAD4; ATPase family AAA domain containing 4

    3. NM_175887.3 → NP_787083.1  proline-rich protein 15

      See identical proteins and their annotated locations for NP_787083.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      BC029131
      Consensus CDS
      CCDS5421.1
      UniProtKB/Swiss-Prot
      Q8IV56
      UniProtKB/TrEMBL
      A4D1A1
      Related
      ENSP00000317836.2, ENST00000319694.3
      Conserved Domains (1) summary
      pfam15321
      Location:13 → 109
      ATAD4; ATPase family AAA domain containing 4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      29563835..29567295
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011515199.2 → XP_011513501.1  proline-rich protein 15 isoform X1

      See identical proteins and their annotated locations for XP_011513501.1

      UniProtKB/Swiss-Prot
      Q8IV56
      UniProtKB/TrEMBL
      A4D1A1
      Conserved Domains (1) summary
      pfam15321
      Location:13 → 109
      ATAD4; ATPase family AAA domain containing 4

    2. XM_011515198.2 → XP_011513500.1  proline-rich protein 15 isoform X1

      See identical proteins and their annotated locations for XP_011513500.1

      UniProtKB/Swiss-Prot
      Q8IV56
      UniProtKB/TrEMBL
      A4D1A1
      Conserved Domains (1) summary
      pfam15321
      Location:13 → 109
      ATAD4; ATPase family AAA domain containing 4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      29701617..29705075
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357569.1 → XP_054213544.1  proline-rich protein 15 isoform X1

    2. XM_054357568.1 → XP_054213543.1  proline-rich protein 15 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IV56.1 GenPept UniProtKB/Swiss-Prot:Q8IV56

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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