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    TMEM184B transmembrane protein 184B [ Homo sapiens (human) ]

    Gene ID: 25829, updated on 11-Apr-2024

    Summary

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    Official Symbol
    TMEM184Bprovided by HGNC
    Official Full Name
    transmembrane protein 184Bprovided by HGNC
    Primary source
    HGNC:HGNC:1310
    See related
    Ensembl:ENSG00000198792 AllianceGenome:HGNC:1310
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FM08; HS5O6A; C22orf5; HSPC256; SLC51C2
    Summary
    Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta (RPKM 20.3), fat (RPKM 18.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    22q13.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (38216395..38273010, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (38680395..38737356, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38615298..38669016, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38482017-38482796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38494339-38494893 Neighboring gene BAR/IMD domain containing adaptor protein 2 like 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38510521-38511423 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38518609-38519118 Neighboring gene phospholipase A2 group VI Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38538756-38539256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18993 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38559728-38560228 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38560229-38560729 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38561911 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38570189 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38572440 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18995 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18996 Neighboring gene Sharpr-MPRA regulatory region 6169 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38580917 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18999 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13707 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13708 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13709 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38600595 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13710 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38603571 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38607237 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38607534 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38608227 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38609813-38610394 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13711 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13712 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr22:38614213-38615412 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38618750-38619250 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38620666-38621166 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38624990-38625720 Neighboring gene TMEM184B antisense RNA 1 Neighboring gene MAF bZIP transcription factor F Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13713 Neighboring gene RNA, 7SL, cytoplasmic 704, pseudogene Neighboring gene small nucleolar RNA, H/ACA box 92 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19001 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38659892-38660392 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr22:38667767-38668476 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13714 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38679509-38680035 Neighboring gene TPTEP2-CSNK1E readthrough Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38685261-38685970 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38685971-38686678 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr22:38694325-38695524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38706687-38707466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19007 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19008 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19009 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13715 Neighboring gene casein kinase 1 epsilon Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38714878-38715782 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38718279-38719070 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38720450-38720962 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr22:38720963-38721473 Neighboring gene Sharpr-MPRA regulatory region 8587 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38723521-38724032 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:38737560-38737744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38740513-38741012 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38743105-38744002 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19010 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13716 Neighboring gene TPTE pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38793649-38794432 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13717

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Transmembrane protein TMEM184B is necessary for interleukin-31-induced itch. Larsen EG, et al. Pain, 2022 May 1. PMID 34629389, Free PMC Article
    2. TMEM184b Promotes Axon Degeneration and Neuromuscular Junction Maintenance. Bhattacharya MR, et al. J Neurosci, 2016 Apr 27. PMID 27122027, Free PMC Article
    3. MicroRNA expression signature of oral squamous cell carcinoma: functional role of microRNA-26a/b in the modulation of novel cancer pathways. Fukumoto I, et al. Br J Cancer, 2015 Mar 3. PMID 25668004, Free PMC Article
    4. Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk. Lindström S, et al. Nat Commun, 2014 Oct 24. PMID 25342443, Free PMC Article
    5. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Matsuda A, et al. Oncogene, 2003 May 22. PMID 12761501

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data shows that miR-26a and miR-26b were significantly downregulated and their direct target, TMEM184B significantly up-regulated in oral squamous cell carcinoma cells.
      Title: MicroRNA expression signature of oral squamous cell carcinoma: functional role of microRNA-26a/b in the modulation of novel cancer pathways.
    2. C22orf5 (FM08) represents a novel gene found during a screening of gene that activate the MAPK pathway.
      Title: Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp586A1024, DKFZp686N1150, DKFZp686F07174

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 184B
    Names
    putative MAPK-activating protein FM08

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195071.1 → NP_001182000.1  transmembrane protein 184B isoform a

      See identical proteins and their annotated locations for NP_001182000.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a different 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform a).
      Source sequence(s)
      AL020993, AL021977, BQ004586, BX648345
      Consensus CDS
      CCDS13969.2
      UniProtKB/Swiss-Prot
      A8K9D7, Q63HM8, Q7Z421, Q8NBM5, Q9UGT8, Q9UGT9, Q9UGV5, Q9Y519
      UniProtKB/TrEMBL
      A0A0J9YYJ3
      Related
      ENSP00000354441.4, ENST00000361684.8
      Conserved Domains (1) summary
      pfam03619
      Location:48 → 317
      Solute_trans_a; Organic solute transporter Ostalpha

    2. NM_001195072.2 → NP_001182001.1  transmembrane protein 184B isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate segment, which results in the use of a downstream, in-frame, start codon, compared to variant 1. The predicted protein (isoform b) has a shorter N-terminus when it is compared to isoform a.
      Source sequence(s)
      AK292652, BC012983, BI197128, BQ004586, CR749859
      UniProtKB/TrEMBL
      A0A0J9YYJ3
      Conserved Domains (1) summary
      pfam03619
      Location:1 → 251
      Solute_trans_a; Organic solute transporter Ostalpha

    3. NM_012264.5 → NP_036396.2  transmembrane protein 184B isoform a

      See identical proteins and their annotated locations for NP_036396.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the most frequently occurring transcript variant. The resulting protein (isoform a) is the longer protein. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK292652, BC012983, BQ004586
      Consensus CDS
      CCDS13969.2
      UniProtKB/Swiss-Prot
      A8K9D7, Q63HM8, Q7Z421, Q8NBM5, Q9UGT8, Q9UGT9, Q9UGV5, Q9Y519
      UniProtKB/TrEMBL
      A0A0J9YYJ3
      Related
      ENSP00000355210.3, ENST00000361906.8
      Conserved Domains (1) summary
      pfam03619
      Location:48 → 317
      Solute_trans_a; Organic solute transporter Ostalpha

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      38216395..38273010 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441319.1 → XP_047297275.1  transmembrane protein 184B isoform X11

    2. XM_047441316.1 → XP_047297272.1  transmembrane protein 184B isoform X9

    3. XM_017028759.2 → XP_016884248.1  transmembrane protein 184B isoform X5

      UniProtKB/TrEMBL
      A0A0J9YYJ3

    4. XM_011530113.2 → XP_011528415.1  transmembrane protein 184B isoform X4

      See identical proteins and their annotated locations for XP_011528415.1

      UniProtKB/TrEMBL
      A0A0J9YYJ3
      Conserved Domains (1) summary
      pfam03619
      Location:46 → 317
      Solute_trans_a; Organic solute transporter Ostalpha

    5. XM_017028756.2 → XP_016884245.1  transmembrane protein 184B isoform X6

      UniProtKB/TrEMBL
      A0A0J9YYJ3
      Related
      ENSP00000488878.1, ENST00000633438.1
      Conserved Domains (1) summary
      pfam03619
      Location:46 → 317
      Solute_trans_a; Organic solute transporter Ostalpha

    6. XM_017028755.2 → XP_016884244.1  transmembrane protein 184B isoform X3

    7. XM_017028754.2 → XP_016884243.1  transmembrane protein 184B isoform X1

    8. XM_011530112.3 → XP_011528414.2  transmembrane protein 184B isoform X2

    9. XM_047441320.1 → XP_047297276.1  transmembrane protein 184B isoform X5

    10. XM_011530114.2 → XP_011528416.1  transmembrane protein 184B isoform X4

      See identical proteins and their annotated locations for XP_011528416.1

      UniProtKB/TrEMBL
      A0A0J9YYJ3
      Conserved Domains (1) summary
      pfam03619
      Location:46 → 317
      Solute_trans_a; Organic solute transporter Ostalpha

    11. XM_011530115.4 → XP_011528417.1  transmembrane protein 184B isoform X7

      Conserved Domains (1) summary
      pfam03619
      Location:96 → 293
      Solute_trans_a; Organic solute transporter Ostalpha

    12. XM_017028757.2 → XP_016884246.1  transmembrane protein 184B isoform X8

    13. XM_047441315.1 → XP_047297271.1  transmembrane protein 184B isoform X4

    14. XM_047441317.1 → XP_047297273.1  transmembrane protein 184B isoform X10

    15. XM_047441318.1 → XP_047297274.1  transmembrane protein 184B isoform X10

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      38680395..38737356 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054325503.1 → XP_054181478.1  transmembrane protein 184B isoform X11

    2. XM_054325500.1 → XP_054181475.1  transmembrane protein 184B isoform X9

    3. XM_054325496.1 → XP_054181471.1  transmembrane protein 184B isoform X5

    4. XM_054325497.1 → XP_054181472.1  transmembrane protein 184B isoform X6

    5. XM_054325492.1 → XP_054181467.1  transmembrane protein 184B isoform X3

    6. XM_054325491.1 → XP_054181466.1  transmembrane protein 184B isoform X2

    7. XM_054325504.1 → XP_054181479.1  transmembrane protein 184B isoform X5

    8. XM_054325499.1 → XP_054181474.1  transmembrane protein 184B isoform X8

    9. XM_054325493.1 → XP_054181468.1  transmembrane protein 184B isoform X4

    10. XM_054325490.1 → XP_054181465.1  transmembrane protein 184B isoform X1

    11. XM_054325494.1 → XP_054181469.1  transmembrane protein 184B isoform X4

    12. XM_054325498.1 → XP_054181473.1  transmembrane protein 184B isoform X7

    13. XM_054325495.1 → XP_054181470.1  transmembrane protein 184B isoform X4

    14. XM_054325501.1 → XP_054181476.1  transmembrane protein 184B isoform X10

    15. XM_054325502.1 → XP_054181477.1  transmembrane protein 184B isoform X10

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y519.2 GenPept UniProtKB/Swiss-Prot:Q9Y519

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