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    SEC11A SEC11 homolog A, signal peptidase complex subunit [ Homo sapiens (human) ]

    Gene ID: 23478, updated on 5-May-2024

    Summary

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    Official Symbol
    SEC11Aprovided by HGNC
    Official Full Name
    SEC11 homolog A, signal peptidase complex subunitprovided by HGNC
    Primary source
    HGNC:HGNC:17718
    See related
    Ensembl:ENSG00000140612 MIM:618258; AllianceGenome:HGNC:17718
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPC18; SPCS4A; SEC11L1; sid2895; 1810012E07Rik
    Summary
    This gene encodes a member of the peptidase S26B family. The encoded protein is an 18kDa subunit of the signal peptidase complex and has been linked to cell migration and invasion, gastric cancer and lymph node metastasis. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Dec 2012]
    Expression
    Ubiquitous expression in thyroid (RPKM 67.9), fat (RPKM 55.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SEC11A in Genome Data Viewer
    Location:
    15q25.2-q25.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (84669544..84716139, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (82421945..82500674, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (85212775..85259370, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene SCAN domain containing 2 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:85196867-85197834 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6771 Neighboring gene WD repeat domain 73 Neighboring gene neuromedin B Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85229719-85230218 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85259023-85259588 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:85259589-85260154 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:85260155-85260718 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:85276857-85277760 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9989 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9990 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9991 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85291347-85292186 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9992 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_41887 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85303845-85304346 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85309319-85309820 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85309821-85310320 Neighboring gene zinc finger protein 592 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9993 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85325731-85326318 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:85326319-85326906 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_41909 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85346873-85347374 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85347375-85347874 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:85359685-85360215 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85362343-85362874 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85362875-85363404 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:85370192-85370692 Neighboring gene skeletal muscle cis-regulatory module overlapping ALPK3 Neighboring gene alpha kinase 3 Neighboring gene uncharacterized LOC124900361

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Clinical Significance of SEC11A Expression in Patients With Locally Advanced Gastric Cancer. Suematsu H, et al. Anticancer Res, 2022 Dec. PMID 36456166
    2. SPC18 Expression Is an Independent Prognostic Indicator of Patients with Esophageal Squamous Cell Carcinoma. Yamamoto Y, et al. Pathobiology, 2020. PMID 32564026
    3. SEC11A Expression Is Associated with Basal-Like Bladder Cancer and Predicts Patient Survival. Shigematsu Y, et al. Pathobiology, 2019. PMID 31163419
    4. Clinicopathological significance of SPC18 in colorectal cancer: SPC18 participates in tumor progression. Hattori T, et al. Cancer Sci, 2017 Jan. PMID 27859949, Free PMC Article
    5. Transcriptome dissection of gastric cancer: identification of novel diagnostic and therapeutic targets from pathology specimens. Yasui W, et al. Pathol Int, 2009 Mar. PMID 19261089

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CircSEC11A knockdown alleviates oxidative stress and apoptosis and promotes cell proliferation and angiogenesis by regulating miR-29a-3p/SEMA3A axis in OGD-induced human brain microvascular endothelial cells (HBMECs).
      Title: CircSEC11A knockdown alleviates oxidative stress and apoptosis and promotes cell proliferation and angiogenesis by regulating miR-29a-3p/SEMA3A axis in OGD-induced human brain microvascular endothelial cells (HBMECs).
    2. Clinical Significance of SEC11A Expression in Patients With Locally Advanced Gastric Cancer.
      Title: Clinical Significance of SEC11A Expression in Patients With Locally Advanced Gastric Cancer.
    3. MiR-873-5p modulates progression of tongue squamous cell carcinoma via targeting SEC11A.
      Title: MiR-873-5p modulates progression of tongue squamous cell carcinoma via targeting SEC11A.
    4. Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage.
      Title: Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage.
    5. SPC18 Expression Is an Independent Prognostic Indicator of Patients with Esophageal Squamous Cell Carcinoma.
      Title: SPC18 Expression Is an Independent Prognostic Indicator of Patients with Esophageal Squamous Cell Carcinoma.
    6. Long non-coding RNA DDX11-AS1 facilitates gastric cancer progression by regulating miR-873-5p/SPC18 axis.
      Title: Long non-coding RNA DDX11-AS1 facilitates gastric cancer progression by regulating miR-873-5p/SPC18 axis.
    7. These results indicate that SPC18 plays an important role in the progression of bladder cancer.
      Title: SEC11A Expression Is Associated with Basal-Like Bladder Cancer and Predicts Patient Survival.
    8. results suggest that SPC18 is involved in tumor progression, and is an independent prognostic classifier in patients with colorectal cancer
      Title: Clinicopathological significance of SPC18 in colorectal cancer: SPC18 participates in tumor progression.
    9. SPC18 contributes to malignant progression through promotion of TGF-alpha secretion in gastric cancer.
      Title: Signal peptidase complex 18, encoded by SEC11A, contributes to progression via TGF-α secretion in gastric cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type endopeptidase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to virus TAS
    Traceable Author Statement
    more info
    		  
    involved_in signal peptide processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal peptide processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of signal peptidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal peptidase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of signal peptidase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    signal peptidase complex catalytic subunit SEC11A
    Names
    SEC11-like protein 1
    SPase 18 kDa subunit
    endopeptidase SP18
    microsomal signal peptidase 18 kDa subunit
    signal peptidase complex (18kD)
    signal peptidase complex 18
    NP_001258847.1
    NP_001258848.1
    NP_001258849.1
    NP_001258850.1
    NP_001258851.1
    NP_055115.1
    XP_054233621.1
    XP_054233622.1
    XP_054233623.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271918.2 → NP_001258847.1  signal peptidase complex catalytic subunit SEC11A isoform 5

      See identical proteins and their annotated locations for NP_001258847.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate exon in the 5' coding region which results in initiation at a downstream start site and an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (5) is longer than isoform 1.
      Source sequence(s)
      AK300693, BM985046, BP370483
      Consensus CDS
      CCDS61742.1
      UniProtKB/Swiss-Prot
      P0C7V7
      Related
      ENSP00000413121.3, ENST00000455959.7
      Conserved Domains (1) summary
      cl10465
      Location:12 → 124
      Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...

    2. NM_001271919.2 → NP_001258848.1  signal peptidase complex catalytic subunit SEC11A isoform 6

      See identical proteins and their annotated locations for NP_001258848.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate in-frame exon and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (6) is longer than isoform 1.
      Source sequence(s)
      AI051931, CD356160, CF455691
      UniProtKB/TrEMBL
      H0YNA5
      Related
      ENSP00000453930.1, ENST00000558217.5
      Conserved Domains (1) summary
      cl10465
      Location:38 → 103
      Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...

    3. NM_001271920.2 → NP_001258849.1  signal peptidase complex catalytic subunit SEC11A isoform 4

      See identical proteins and their annotated locations for NP_001258849.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses two alternate exons in the central coding region which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (4) is longer and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BF920344, BG703137, BI545042, BM985046, BP370483
      Consensus CDS
      CCDS61744.1
      UniProtKB/TrEMBL
      H0YNG3
      Related
      ENSP00000452684.1, ENST00000560266.5
      Conserved Domains (1) summary
      cl10465
      Location:38 → 122
      Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...

    4. NM_001271921.2 → NP_001258850.1  signal peptidase complex catalytic subunit SEC11A isoform 1

      See identical proteins and their annotated locations for NP_001258850.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript and encodes the shortest isoform (1).
      Source sequence(s)
      AA151795, AF061737, BM763471, HY170714
      Consensus CDS
      CCDS73776.1
      UniProtKB/TrEMBL
      H0YKT4
      Related
      ENSP00000452932.1, ENST00000559729.5

    5. NM_001271922.2 → NP_001258851.1  signal peptidase complex catalytic subunit SEC11A isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame exon and lacks an exon in the 3' coding region which results in a frameshift, compared to variant 1. The encoded isoform (3) is longer and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC000359, BM763471, BM904189
      Consensus CDS
      CCDS61743.1
      UniProtKB/Swiss-Prot
      P67812
      Related
      ENSP00000452697.1, ENST00000558134.5
      Conserved Domains (1) summary
      cl10465
      Location:38 → 122
      Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...

    6. NM_014300.4 → NP_055115.1  signal peptidase complex catalytic subunit SEC11A isoform 2

      See identical proteins and their annotated locations for NP_055115.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame exon in the central coding region, compared to variant 1. It encodes a longer protein (isoform 2) compared to isoform 1.
      Source sequence(s)
      BC014508, DC360846
      Consensus CDS
      CCDS45340.1
      UniProtKB/Swiss-Prot
      B2RAD7, B4DUL4, H0YK72, H0YK83, O75957, P21378, P67812, Q53FQ8
      UniProtKB/TrEMBL
      Q6IAM7
      Related
      ENSP00000268220.7, ENST00000268220.12
      Conserved Domains (1) summary
      cl10465
      Location:38 → 150
      Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...

    RNA

    1. NR_073518.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) contains two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA151795, AF061737, BM763471, CT001736

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      84669544..84716139 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      82421945..82500674 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377648.1 → XP_054233623.1  signal peptidase complex catalytic subunit SEC11A isoform X1

      UniProtKB/Swiss-Prot
      B2RAD7, B4DUL4, H0YK72, H0YK83, O75957, P21378, P67812, Q53FQ8

    2. XM_054377646.1 → XP_054233621.1  signal peptidase complex catalytic subunit SEC11A isoform X1

      UniProtKB/Swiss-Prot
      B2RAD7, B4DUL4, H0YK72, H0YK83, O75957, P21378, P67812, Q53FQ8

    3. XM_054377647.1 → XP_054233622.1  signal peptidase complex catalytic subunit SEC11A isoform X1

      UniProtKB/Swiss-Prot
      B2RAD7, B4DUL4, H0YK72, H0YK83, O75957, P21378, P67812, Q53FQ8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P67812.1 GenPept UniProtKB/Swiss-Prot:P67812

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