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    MAGI2-AS3 MAGI2 antisense RNA 3 [ Homo sapiens (human) ]

    Gene ID: 100505881, updated on 10-Oct-2023

    Summary

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    Official Symbol
    MAGI2-AS3provided by HGNC
    Official Full Name
    MAGI2 antisense RNA 3provided by HGNC
    Primary source
    HGNC:HGNC:40862
    See related
    Ensembl:ENSG00000234456 AllianceGenome:HGNC:40862
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in fat (RPKM 9.7), ovary (RPKM 7.7) and 23 other tissues See more
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    Genomic context

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    See MAGI2-AS3 in Genome Data Viewer
    Location:
    7q21.11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (79452957..79471208)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (80704760..80722989)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (79082273..79100524)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene membrane associated guanylate kinase, WW and PDZ domain containing 2 Neighboring gene uncharacterized LOC124901823 Neighboring gene RNA, U6 small nuclear 530, pseudogene Neighboring gene Sharpr-MPRA regulatory region 13814 Neighboring gene uncharacterized LOC105375369 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:79275496-79276123 Neighboring gene nucleoporin 35 pseudogene 2 Neighboring gene RNA, 5S ribosomal pseudogene 234

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Role of MAGI2-AS3 in malignant and non-malignant disorders. Taheri M, et al. Pathol Res Pract, 2023 Jun. PMID 37196468
    2. Role of lncRNA MAGI2-AS3 in lipopolysaccharide-induced nucleus pulposus cells injury by regulating miR-374b-5p/interleukin-10 axis. Yu J, et al. Immun Inflamm Dis, 2023 Apr. PMID 37102649, Free PMC Article
    3. Roles of lncRNA MAGI2-AS3 in human cancers. Kai-Xin L, et al. Biomed Pharmacother, 2021 Sep. PMID 34126355
    4. Long noncoding RNA MAGI2-AS3 inhibits bladder cancer progression through MAGI2/PTEN/epithelial-mesenchymal transition (EMT) axis. Shen D, et al. Cancer Biomark, 2021. PMID 33104021
    5. MAGI2-AS3 suppresses MYC signaling to inhibit cell proliferation and migration in ovarian cancer through targeting miR-525-5p/MXD1 axis. Chang H, et al. Cancer Med, 2020 Sep. PMID 32681706, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long Noncoding RNA MAGI2-AS3 Represses Cell Progression in Clear Cell Renal Cell Carcinoma by Modulating the miR-629-5p/PRDM16 Axis.
      Title: Long Noncoding RNA MAGI2-AS3 Represses Cell Progression in Clear Cell Renal Cell Carcinoma by Modulating the miR-629-5p/PRDM16 Axis.
    2. Role of MAGI2-AS3 in malignant and non-malignant disorders.
      Title: Role of MAGI2-AS3 in malignant and non-malignant disorders.
    3. Role of lncRNA MAGI2-AS3 in lipopolysaccharide-induced nucleus pulposus cells injury by regulating miR-374b-5p/interleukin-10 axis.
      Title: Role of lncRNA MAGI2-AS3 in lipopolysaccharide-induced nucleus pulposus cells injury by regulating miR-374b-5p/interleukin-10 axis.
    4. lncRNA MAGI2-AS3 suppresses castration-resistant prostate cancer proliferation and migration via the miR-106a-5p/RAB31 axis.
      Title: lncRNA MAGI2-AS3 suppresses castration-resistant prostate cancer proliferation and migration via the miR-106a-5p/RAB31 axis.
    5. MAGI2-AS3 and miR-374b-5p as Putative Regulators of Multiple Sclerosis via Modulating the PTEN/AKT/IRF-3/IFN-beta Axis: New Clinical Insights.
      Title: MAGI2-AS3 and miR-374b-5p as Putative Regulators of Multiple Sclerosis via Modulating the PTEN/AKT/IRF-3/IFN-β Axis: New Clinical Insights.
    6. Hypermethylation-Mediated lncRNA MAGI2-AS3 Downregulation Facilitates Malignant Progression of Laryngeal Squamous Cell Carcinoma via Interacting With SPT6.
      Title: Hypermethylation-Mediated lncRNA MAGI2-AS3 Downregulation Facilitates Malignant Progression of Laryngeal Squamous Cell Carcinoma via Interacting With SPT6.
    7. LncRNA MAGI2-AS3 Inhibits Prostate Cancer Progression by Targeting the miR-142-3p.
      Title: LncRNA MAGI2-AS3 Inhibits Prostate Cancer Progression by Targeting the miR-142-3p.
    8. Long noncoding RNA MAGI2-AS3 regulates the H2O2 level and cell senescence via HSPA8.
      Title: Long noncoding RNA MAGI2-AS3 regulates the H(2)O(2) level and cell senescence via HSPA8.
    9. LncRNA MAGI2-AS3 inhibits tumor progression and angiogenesis by regulating ACY1 via interacting with transcription factor HEY1 in clear cell renal cell carcinoma.
      Title: LncRNA MAGI2-AS3 inhibits tumor progression and angiogenesis by regulating ACY1 via interacting with transcription factor HEY1 in clear cell renal cell carcinoma.
    10. MicroRNA MiR-490-5p suppresses pancreatic cancer through regulating epithelial-mesenchymal transition via targeting MAGI2 antisense RNA 3.
      Title: MicroRNA MiR-490-5p suppresses pancreatic cancer through regulating epithelial-mesenchymal transition via targeting MAGI2 antisense RNA 3.
    Submit: New GeneRIF Correction See all GeneRIFs (25)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Other Names

    • MAGI2 antisense RNA 3 (non-protein coding)

    Clone Names

    • DKFZp686F08110

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_038343.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AC004945, AK311103, BI521274, GD146486

    2. NR_038344.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks the 3' exon and includes two alternate 3' exons, compared to variant 1.
      Source sequence(s)
      BI521274, BQ008953, CN311982
      Related
      ENST00000414797.7

    3. NR_038345.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two 5' and the 3' exons and includes an alternate 5' and two alternate 3' exons, compared to variant 1.
      Source sequence(s)
      AB371456, BQ008953, DA758742
      Related
      ENST00000426835.6

    4. NR_038346.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two 5' and the 3' exons and includes two alternate 5' and an alternate 3' exons, compared to variant 1.
      Source sequence(s)
      BI868593, BQ008953, DA758742

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      79452957..79471208
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      80704760..80722989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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