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    KRT31 keratin 31 [ Homo sapiens (human) ]

    Gene ID: 3881, updated on 7-Apr-2024

    Summary

    Official Symbol
    KRT31provided by HGNC
    Official Full Name
    keratin 31provided by HGNC
    Primary source
    HGNC:HGNC:6448
    See related
    Ensembl:ENSG00000094796 MIM:601077; AllianceGenome:HGNC:6448
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HA1; Ha-1; hHa1; KRTHA1
    Summary
    The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in skin (RPKM 18.4) and esophagus (RPKM 9.5) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    17q21.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (41393721..41397608, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (42249250..42253137, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39549973..39553860, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39520859-39521360 Neighboring gene keratin 33B Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:39537551-39538750 Neighboring gene keratin 34 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39549785-39550286 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39550287-39550786 Neighboring gene uncharacterized LOC100505782 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:39559942-39561141 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39567789-39568290 Neighboring gene keratin 41, pseudogene Neighboring gene Sharpr-MPRA regulatory region 10866 Neighboring gene keratin 37

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC138630

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in epidermis development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular space HDA PubMed 
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    keratin, type I cuticular Ha1
    Names
    K31
    hair keratin, type I Ha1
    hard keratin, type I, 1
    keratin 31, type I
    keratin, hair, acidic,1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012288.1 RefSeqGene

      Range
      4985..8872
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002277.3NP_002268.2  keratin, type I cuticular Ha1

      See identical proteins and their annotated locations for NP_002268.2

      Status: REVIEWED

      Source sequence(s)
      AC003958
      Consensus CDS
      CCDS11391.1
      UniProtKB/Swiss-Prot
      Q15323, Q9UE12
      Related
      ENSP00000251645.2, ENST00000251645.3
      Conserved Domains (1) summary
      pfam00038
      Location:55366
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      41393721..41397608 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791801.1 Reference GRCh38.p14 PATCHES

      Range
      333625..337512 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003315953.2 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      35353..39240
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      42249250..42253137 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)