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    TRG-AS1 T cell receptor gamma locus antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 100506776, updated on 10-Jun-2024

    Summary

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    Official Symbol
    TRG-AS1provided by HGNC
    Official Full Name
    T cell receptor gamma locus antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:48974
    See related
    Ensembl:ENSG00000281103 AllianceGenome:HGNC:48974
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TCRGV
    Expression
    Biased expression in spleen (RPKM 8.0), lymph node (RPKM 2.9) and 10 other tissues See more
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    Genomic context

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    See TRG-AS1 in Genome Data Viewer
    Location:
    7p14.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (38341577..38378637)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (38498459..38535519)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (38381178..38418238)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene T cell receptor gamma locus Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25867 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25868 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25869 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25871 Neighboring gene Sharpr-MPRA regulatory region 15414 Neighboring gene T cell receptor gamma variable 7 (pseudogene) Neighboring gene T cell receptor gamma variable 5P (pseudogene) Neighboring gene T cell receptor gamma variable 6 (pseudogene) Neighboring gene T cell receptor gamma variable 5 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98536 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98538 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_98539 and experimental_98540 Neighboring gene T cell receptor gamma variable 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25872 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98545 Neighboring gene T cell receptor gamma variable 3 Neighboring gene T cell receptor gamma variable 2 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98547 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98548 Neighboring gene T cell receptor gamma variable 1 (non-functional) Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98550 Neighboring gene amphiphysin Neighboring gene ReSE screen-validated silencer GRCh37_chr7:38473600-38473818 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98556 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98558 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98567 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25873 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98573 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98575/98576 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98581 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98586 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98589 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98595 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98599 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98607 Neighboring gene RNA, 7SL, cytoplasmic 83, pseudogene Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr7:38629347-38629908 Neighboring gene keratin 8 pseudogene 20

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LncRNA TRG-AS1 inhibits bone metastasis of breast cancer by the miR-877-5p/WISP2 axis. Zhu J, et al. Pathol Res Pract, 2023 Mar. PMID 36801505
    2. LncRNA TRG-AS1 promotes glioblastoma cell proliferation by competitively binding with miR-877-5p to regulate SUZ12 expression. Xie H, et al. Pathol Res Pract, 2019 Aug. PMID 31196742
    3. Repertoire of the human T cell gamma genes: high frequency of nonfunctional transcripts in thymus and mature T cells. Yoshikai Y, et al. Eur J Immunol, 1987 Jan. PMID 2949984

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The lncRNA TRG-AS1 promotes the growth of colorectal cancer cells through the regulation of P2RY10/GNA13.
      Title: The lncRNA TRG-AS1 promotes the growth of colorectal cancer cells through the regulation of P2RY10/GNA13.
    2. LncRNA TRG-AS1 inhibits bone metastasis of breast cancer by the miR-877-5p/WISP2 axis.
      Title: LncRNA TRG-AS1 inhibits bone metastasis of breast cancer by the miR-877-5p/WISP2 axis.
    3. TRG-AS1 promotes glioblastoma cell proliferation by acting as a ceRNA of miR-877-5p to regulate SUZ12 expression
      Title: LncRNA TRG-AS1 promotes glioblastoma cell proliferation by competitively binding with miR-877-5p to regulate SUZ12 expression.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Other Names

    • TRG antisense RNA 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_040085.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC007245, AK125646, BQ002637
      Related
      ENST00000629357.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      38341577..38378637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      38498459..38535519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials