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    Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 50688, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Cacnb1provided by RGD
    Official Full Name
    calcium voltage-gated channel auxiliary subunit beta 1provided by RGD
    Primary source
    RGD:68382
    See related
    Ensembl:ENSRNOG00000004518 AllianceGenome:RGD:68382
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CAB1
    Summary
    Enables several functions, including identical protein binding activity; phosphoprotein binding activity; and protein kinase binding activity. Contributes to voltage-gated calcium channel activity. Predicted to be involved in several processes, including cellular response to amyloid-beta; neuromuscular junction development; and regulation of calcium ion transmembrane transport. Predicted to act upstream of or within calcium ion transport and protein targeting to membrane. Part of voltage-gated calcium channel complex. Is active in glutamatergic synapse and postsynapse. Orthologous to human CACNB1 (calcium voltage-gated channel auxiliary subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 152.9), Brain (RPKM 44.1) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cacnb1 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (83494509..83515164, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (82998182..83018838, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (85954138..85974764, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480866 Neighboring gene transfer RNA cysteine (anticodon GCA) 37 Neighboring gene ADP-ribosylation factor like GTPase 5C Neighboring gene ribosomal protein L19 Neighboring gene SH3 and cysteine rich domain 2 Neighboring gene uncharacterized LOC102548674

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The guanylate kinase domain of the beta-subunit of voltage-gated calcium channels suffices to modulate gating. Gonzalez-Gutierrez G, et al. Proc Natl Acad Sci U S A, 2008 Sep 16. PMID 18776052, Free PMC Article
    2. Interaction via a key tryptophan in the I-II linker of N-type calcium channels is required for beta1 but not for palmitoylated beta2, implicating an additional binding site in the regulation of channel voltage-dependent properties. Leroy J, et al. J Neurosci, 2005 Jul 27. PMID 16049174, Free PMC Article
    3. Cloning and tissue-specific expression of the brain calcium channel beta-subunit. Pragnell M, et al. FEBS Lett, 1991 Oct 21. PMID 1657644
    4. CaMKII associates with CaV1.2 L-type calcium channels via selected beta subunits to enhance regulatory phosphorylation. Abiria SA, et al. J Neurochem, 2010 Jan. PMID 19840220, Free PMC Article
    5. Modulation of CaV2.1 channels by the neuronal calcium-binding protein visinin-like protein-2. Lautermilch NJ, et al. J Neurosci, 2005 Jul 27. PMID 16049183, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables high voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables high voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phosphoprotein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to voltage-gated calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables voltage-gated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to amyloid-beta IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to amyloid-beta ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuromuscular junction development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in T-tubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of voltage-gated calcium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated calcium channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of voltage-gated calcium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated calcium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    voltage-dependent L-type calcium channel subunit beta-1
    Names
    brain calcium channel beta 1 subunit
    calcium channel beta 1 subunit
    calcium channel voltage-dependent subunit beta 1
    calcium channel, voltage-dependent, beta 1 subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017346.2 → NP_059042.2  voltage-dependent L-type calcium channel subunit beta-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P54283
      UniProtKB/TrEMBL
      A6HIP2, G3V6K8
      Related
      ENSRNOP00000006098.4, ENSRNOT00000006098.6
      Conserved Domains (3) summary
      pfam00625
      Location:228 → 408
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:58 → 99
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl17036
      Location:99 → 166
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      83494509..83515164 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247409.5 → XP_006247471.1  voltage-dependent L-type calcium channel subunit beta-1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4U4, A0A8I5ZLV2
      Related
      ENSRNOP00000073177.1
      Conserved Domains (3) summary
      pfam00625
      Location:273 → 453
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:58 → 99
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl17036
      Location:99 → 166
      SH3; Src Homology 3 domain superfamily

    2. XM_006247410.4 → XP_006247472.1  voltage-dependent L-type calcium channel subunit beta-1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZLV2, A0A8I6ASP4
      Related
      ENSRNOP00000091590.1
      Conserved Domains (4) summary
      cd12041
      Location:52 → 119
      SH3_CACNB1; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta-1
      smart00072
      Location:236 → 407
      GuKc; Guanylate kinase homologues
      pfam00625
      Location:226 → 406
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:11 → 52
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal

    3. XM_039086662.2 → XP_038942590.1  voltage-dependent L-type calcium channel subunit beta-1 isoform X3

      UniProtKB/TrEMBL
      A6HIP4
      Conserved Domains (1) summary
      pfam00625
      Location:1 → 180
      Guanylate_kin; Guanylate kinase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54283.1 GenPept UniProtKB/Swiss-Prot:P54283

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