U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Epha5 EPH receptor A5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79208, updated on 2-May-2024

    Summary

    Official Symbol
    Epha5provided by RGD
    Official Full Name
    EPH receptor A5provided by RGD
    Primary source
    RGD:620831
    See related
    Ensembl:ENSRNOG00000002024 AllianceGenome:RGD:620831
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Els1; EHK-1; Els1.
    Summary
    Enables ephrin receptor activity and growth factor binding activity. Involved in several processes, including cAMP-mediated signaling; dendritic spine morphogenesis; and ephrin receptor signaling pathway. Acts upstream of or within negative regulation of cell adhesion. Located in axon and plasma membrane. Orthologous to human EPHA5 (EPH receptor A5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 132.9) and Adrenal (RPKM 8.7) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    14p21
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (24007400..24374854)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (23653393..24020129)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (25589312..25958258)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene myelin-associated oligodendrocyte basic protein, pseudogene 1 Neighboring gene ribosomal protein L9 like 1 Neighboring gene uncharacterized LOC120096592 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GPI-linked ephrin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GPI-linked ephrin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ephrin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables growth factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane-ephrin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cAMP-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to follicle-stimulating hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to forskolin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dendritic spine morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ephrin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ephrin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ephrin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ephrin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hippocampus development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hippocampus development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuron development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of insulin secretion involved in cellular response to glucose stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in rough endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ephrin type-A receptor 5
    Names
    EPH homology kinase 1
    eck-like sequence 1
    tyrosine-protein kinase receptor EHK-1
    NP_001162608.1
    NP_077343.1
    XP_063129722.1
    XP_063129723.1
    XP_063129724.1
    XP_063129725.1
    XP_063129726.1
    XP_063129727.1
    XP_063129729.1
    XP_063129730.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001169137.3NP_001162608.1  ephrin type-A receptor 5 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      P54757
      Related
      ENSRNOP00000002793.4, ENSRNOT00000002793.6
      Conserved Domains (7) summary
      cd09546
      Location:9671032
      SAM_EPH-A5; SAM domain of EPH-A5 subfamily of tyrosine kinase receptors
      smart00454
      Location:9711029
      SAM; Sterile alpha motif
      cd00063
      Location:471561
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:672938
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam07714
      Location:677934
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:580672
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl02704
      Location:62234
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
    2. NM_024367.2NP_077343.1  ephrin type-A receptor 5 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region and uses an alternate splice pattern in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment and has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      D3ZCV9
      Related
      ENSRNOP00000062326.3, ENSRNOT00000067439.5
      Conserved Domains (5) summary
      cd00063
      Location:359449
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:560826
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam14575
      Location:464562
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl02704
      Location:62234
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
      cl15755
      Location:855893
      SAM_superfamily; SAM (Sterile alpha motif )

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      24007400..24374854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273652.1XP_063129722.1  ephrin type-A receptor 5 isoform X1

      UniProtKB/TrEMBL
      F1M7W0
    2. XM_063273653.1XP_063129723.1  ephrin type-A receptor 5 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A019
    3. XM_063273654.1XP_063129724.1  ephrin type-A receptor 5 isoform X3

    4. XM_063273655.1XP_063129725.1  ephrin type-A receptor 5 isoform X4

    5. XM_063273656.1XP_063129726.1  ephrin type-A receptor 5 isoform X5

    6. XM_063273657.1XP_063129727.1  ephrin type-A receptor 5 isoform X6

      UniProtKB/TrEMBL
      D3ZBZ7
    7. XM_063273659.1XP_063129729.1  ephrin type-A receptor 5 isoform X7

    8. XM_063273660.1XP_063129730.1  ephrin type-A receptor 5 isoform X8