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    Rnpepl1 arginyl aminopeptidase like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 684035, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rnpepl1provided by RGD
    Official Full Name
    arginyl aminopeptidase like 1provided by RGD
    Primary source
    RGD:1595210
    See related
    Ensembl:ENSRNOG00000045775 AllianceGenome:RGD:1595210
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metalloaminopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human RNPEPL1 (arginyl aminopeptidase like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 84.1), Kidney (RPKM 68.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rnpepl1 in Genome Data Viewer
    Location:
    9q36
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (100921053..100933748)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (93476600..93486331)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (100080144..100089834)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene glypican 1 Neighboring gene uncharacterized LOC134480611 Neighboring gene uncharacterized LOC120094747 Neighboring gene ankyrin repeat and MYND domain containing 1 Neighboring gene dual specificity phosphatase 28 Neighboring gene calpain 10 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Horikawa Y, et al. Nat Genet, 2000 Oct. PMID 11017071
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metalloaminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloaminopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    aminopeptidase RNPEPL1
    Names
    arginyl aminopeptidase (aminopeptidase B)-like 1
    NP_001258106.1
    XP_038940140.1
    XP_063123809.1
    XP_063123811.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271177.1 → NP_001258106.1  aminopeptidase RNPEPL1

      Status: VALIDATED

      Source sequence(s)
      CH473997
      UniProtKB/TrEMBL
      M0RA44
      Related
      ENSRNOP00000066384.3, ENSRNOT00000071411.3
      Conserved Domains (3) summary
      cd09599
      Location:30 → 507
      M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
      TIGR02411
      Location:32 → 668
      leuko_A4_hydro; leukotriene A-4 hydrolase/aminopeptidase
      pfam09127
      Location:527 → 667
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      100921053..100933748
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084212.2 → XP_038940140.1  aminopeptidase RNPEPL1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GLG5, M0RA44
      Related
      ENSRNOP00000095096.1
      Conserved Domains (2) summary
      cd09599
      Location:29 → 469
      M1_LTA4H; Peptidase M1 family including Leukotriene A4 hydrolase catalytic domain
      pfam09127
      Location:517 → 630
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal

    2. XM_063267739.1 → XP_063123809.1  aminopeptidase RNPEPL1 isoform X2

    3. XM_063267741.1 → XP_063123811.1  aminopeptidase RNPEPL1 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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