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    Gtf2e1 general transcription factor IIE subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303918, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Gtf2e1provided by RGD
    Official Full Name
    general transcription factor IIE subunit 1provided by RGD
    Primary source
    RGD:1306851
    See related
    Ensembl:ENSRNOG00000026008 AllianceGenome:RGD:1306851
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA polymerase II general transcription initiation factor activity. Predicted to be involved in transcription open complex formation at RNA polymerase II promoter. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of transcription factor TFIID complex; transcription factor TFIIE complex; and transcription preinitiation complex. Orthologous to human GTF2E1 (general transcription factor IIE subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 46.1), Kidney (RPKM 40.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gtf2e1 in Genome Data Viewer
    Location:
    11q21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (76687382..76720253)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (63182073..63215349)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (66078786..66111394)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene keratin, type II cytoskeletal 8-like Neighboring gene homogentisate 1, 2-dioxygenase Neighboring gene RAB, member of RAS oncogene family-like 3 Neighboring gene U2 spliceosomal RNA Neighboring gene syntaxin binding protein 5L Neighboring gene ring finger protein 138, pseudogene 4 Neighboring gene DNA polymerase theta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural insights into transcription initiation by RNA polymerase II. Grünberg S, et al. Trends Biochem Sci, 2013 Dec. PMID 24120742, Free PMC Article
    2. Oestrogen receptor facilitates the formation of preinitiation complex assembly: involvement of the general transcription factor TFIIB. Sabbah M, et al. Biochem J, 1998 Dec 15. PMID 9841876, Free PMC Article
    3. Near-atomic resolution visualization of human transcription promoter opening. He Y, et al. Nature, 2016 May 19. PMID 27193682, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription open complex formation at RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIIE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    general transcription factor IIE subunit 1
    Names
    general transcription factor IIE, polypeptide 1 (alpha subunit)
    general transcription factor IIE, polypeptide 1, alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100556.1 → NP_001094026.1  general transcription factor IIE subunit 1

      See identical proteins and their annotated locations for NP_001094026.1

      Status: VALIDATED

      Source sequence(s)
      BC099237, CA509437, DY311373
      UniProtKB/TrEMBL
      A6IR94, G3V992
      Related
      ENSRNOP00000039601.3, ENSRNOT00000042864.5
      Conserved Domains (2) summary
      smart00531
      Location:28 → 175
      TFIIE; Transcription initiation factor IIE
      pfam11521
      Location:393 → 438
      TFIIE-A_C; C-terminal general transcription factor TFIIE alpha

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      76687382..76720253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088355.2 → XP_038944283.1  general transcription factor IIE subunit 1 isoform X1

      UniProtKB/TrEMBL
      A6IR94, G3V992
      Conserved Domains (2) summary
      smart00531
      Location:28 → 175
      TFIIE; Transcription initiation factor IIE
      pfam11521
      Location:393 → 438
      TFIIE-A_C; C-terminal general transcription factor TFIIE alpha

    2. XM_017597999.3 → XP_017453488.1  general transcription factor IIE subunit 1 isoform X1

      UniProtKB/TrEMBL
      A6IR94, G3V992
      Conserved Domains (2) summary
      smart00531
      Location:28 → 175
      TFIIE; Transcription initiation factor IIE
      pfam11521
      Location:393 → 438
      TFIIE-A_C; C-terminal general transcription factor TFIIE alpha

    3. XM_039088354.2 → XP_038944282.1  general transcription factor IIE subunit 1 isoform X1

      UniProtKB/TrEMBL
      A6IR94, G3V992
      Conserved Domains (2) summary
      smart00531
      Location:28 → 175
      TFIIE; Transcription initiation factor IIE
      pfam11521
      Location:393 → 438
      TFIIE-A_C; C-terminal general transcription factor TFIIE alpha

    4. XM_008768731.4 → XP_008766953.1  general transcription factor IIE subunit 1 isoform X1

      See identical proteins and their annotated locations for XP_008766953.1

      UniProtKB/TrEMBL
      A6IR94, G3V992
      Conserved Domains (2) summary
      smart00531
      Location:28 → 175
      TFIIE; Transcription initiation factor IIE
      pfam11521
      Location:393 → 438
      TFIIE-A_C; C-terminal general transcription factor TFIIE alpha
    Nucleotide Protein Strain
    Heading Accession and Version

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