Pex5 peroxisomal biogenesis factor 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Pex5provided by RGD
Full Name: peroxisomal biogenesis factor 5provided by RGD
Primary source: RGD:1307612
See related: Ensembl:ENSRNOG00000049203 AllianceGenome:RGD:1307612
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PTS1R; PTS1-BP
Summary: Predicted to enable several functions, including peroxisome targeting sequence binding activity; protein C-terminus binding activity; and protein sequestering activity. Predicted to be involved in negative regulation of protein-containing complex assembly; protein targeting to peroxisome; and protein tetramerization. Predicted to act upstream of or within several processes, including fatty acid metabolic process; mitochondrial membrane organization; and nervous system development. Located in cytosol and peroxisomal membrane. Part of protein-containing complex. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 2A; peroxisome biogenesis disorder 2B; and rhizomelic chondrodysplasia punctata type 5. Orthologous to human PEX5 (peroxisomal biogenesis factor 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 228.6), Kidney (RPKM 179.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (158956973..158983581, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (157270671..157296432, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (156983914..157009675, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Noncanonical and reversible cysteine ubiquitination prevents the overubiquitination of PEX5 at the peroxisomal membrane.
Title: Noncanonical and reversible cysteine ubiquitination prevents the overubiquitination of PEX5 at the peroxisomal membrane.
PEX5 prevents cardiomyocyte hypertrophy via suppressing the redox-sensitive signaling pathways MAPKs and STAT3.
Title: PEX5 prevents cardiomyocyte hypertrophy via suppressing the redox-sensitive signaling pathways MAPKs and STAT3.
Our results suggest that ubiquitin-specific protease 9X (USP9X) is by far the most active deubiquitinase acting on Ub-PEX5, both in female rat liver and HeLa cells.
Title: Identification of ubiquitin-specific protease 9X (USP9X) as a deubiquitinase acting on ubiquitin-peroxin 5 (PEX5) thioester conjugate.
Ubiquitination of rat Pex5p, the peroxisomal import receptor, is reported.
Title: Ubiquitination of mammalian Pex5p, the peroxisomal import receptor.
the N terminus of Pex5p is required for redirecting the peroxisome-associated peroxin back to the cytosol
Title: The N terminus of the peroxisomal cycling receptor, Pex5p, is required for redirecting the peroxisome-associated peroxin back to the cytosol.
Pex5p interacts with cargo proteins in the cytosol and transports them to the peroxisomal membrane.
Title: The energetics of Pex5p-mediated peroxisomal protein import.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables peroxisome matrix targeting signal-1 binding	IBA Inferred from Biological aspect of Ancestor more info
enables peroxisome matrix targeting signal-1 binding	ISO Inferred from Sequence Orthology more info
enables peroxisome matrix targeting signal-1 binding	ISS Inferred from Sequence or Structural Similarity more info
enables peroxisome membrane targeting sequence binding	ISO Inferred from Sequence Orthology more info
enables peroxisome targeting sequence binding	ISO Inferred from Sequence Orthology more info
enables protein carrier chaperone	ISO Inferred from Sequence Orthology more info
enables protein carrier chaperone	ISS Inferred from Sequence or Structural Similarity more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebral cortex cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebral cortex neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endoplasmic reticulum organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within isoprenoid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrial membrane organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peroxisome organization	ISO Inferred from Sequence Orthology more info
involved_in pexophagy	ISO Inferred from Sequence Orthology more info
involved_in pexophagy	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in protein import into peroxisome matrix	ISO Inferred from Sequence Orthology more info
involved_in protein import into peroxisome matrix	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein import into peroxisome matrix, docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into peroxisome matrix, docking	ISO Inferred from Sequence Orthology more info
involved_in protein import into peroxisome matrix, receptor recycling	ISO Inferred from Sequence Orthology more info
involved_in protein import into peroxisome matrix, receptor recycling	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein import into peroxisome matrix, substrate release	ISO Inferred from Sequence Orthology more info
involved_in protein import into peroxisome matrix, substrate release	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein import into peroxisome matrix, translocation	ISO Inferred from Sequence Orthology more info
involved_in protein import into peroxisome membrane	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to peroxisome	ISO Inferred from Sequence Orthology more info
involved_in protein tetramerization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within very long-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in peroxisomal matrix	IEA Inferred from Electronic Annotation more info
is_active_in peroxisomal matrix	ISO Inferred from Sequence Orthology more info
located_in peroxisomal matrix	ISO Inferred from Sequence Orthology more info
is_active_in peroxisomal matrix	ISS Inferred from Sequence or Structural Similarity more info
is_active_in peroxisomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peroxisomal targeting signal 1 receptor

Names: PTS1 receptor; peroxin-5; peroxisomal C-terminal targeting signal import receptor; peroxisomal targeting signal 1 receptor-like; peroxisome biogenesis factor 5; peroxisome receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170584.1 → NP_001164055.1 peroxisomal targeting signal 1 receptor

See identical proteins and their annotated locations for NP_001164055.1

Status: VALIDATED

Source sequence(s)

BC111709, CB809540, CK469240, CK477113, EV779934, FM036217

UniProtKB/Swiss-Prot

Q2M2R8

UniProtKB/TrEMBL

A6ILI2, M0R4L3

Related

ENSRNOP00000064300.1, ENSRNOT00000071625.3

Conserved Domains (3) summary

TIGR02917
Location:305 → 548

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:453 → 481

TPR; TPR repeat [structural motif]

cl02686
Location:270 → 305

PRY; SPRY-associated domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

158956973..158983581 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063286136.1 → XP_063142206.1 peroxisomal targeting signal 1 receptor isoform X2

UniProtKB/TrEMBL

A6ILI2, M0R4L3
XM_063286132.1 → XP_063142202.1 peroxisomal targeting signal 1 receptor isoform X1

UniProtKB/TrEMBL

A0A9M1WVX5
XM_063286131.1 → XP_063142201.1 peroxisomal targeting signal 1 receptor isoform X1

UniProtKB/TrEMBL

A0A9M1WVX5
XM_006237384.3 → XP_006237446.1 peroxisomal targeting signal 1 receptor isoform X1

See identical proteins and their annotated locations for XP_006237446.1

UniProtKB/Swiss-Prot

Q2M2R8

UniProtKB/TrEMBL

A0A9M1WVX5

Related

ENSRNOP00000014028.5

Conserved Domains (4) summary

sd00006
Location:490 → 518

TPR; TPR repeat [structural motif]

pfam00515
Location:490 → 523

TPR_1; Tetratricopeptide repeat

pfam13414
Location:489 → 555

TPR_11; TPR repeat

cl02686
Location:307 → 342

PRY; SPRY-associated domain
XM_063286135.1 → XP_063142205.1 peroxisomal targeting signal 1 receptor isoform X2

UniProtKB/TrEMBL

A6ILI2, M0R4L3
XM_063286130.1 → XP_063142200.1 peroxisomal targeting signal 1 receptor isoform X1

UniProtKB/TrEMBL

A0A9M1WVX5
XM_006237385.5 → XP_006237447.1 peroxisomal targeting signal 1 receptor isoform X1

See identical proteins and their annotated locations for XP_006237447.1

UniProtKB/Swiss-Prot

Q2M2R8

UniProtKB/TrEMBL

A0A9M1WVX5

Conserved Domains (4) summary

sd00006
Location:490 → 518

TPR; TPR repeat [structural motif]

pfam00515
Location:490 → 523

TPR_1; Tetratricopeptide repeat

pfam13414
Location:489 → 555

TPR_11; TPR repeat

cl02686
Location:307 → 342

PRY; SPRY-associated domain
XM_063286134.1 → XP_063142204.1 peroxisomal targeting signal 1 receptor isoform X2

UniProtKB/TrEMBL

A6ILI2, M0R4L3