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    Wdsub1 WD repeat, sterile alpha motif and U-box domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362137, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Wdsub1provided by RGD
    Official Full Name
    WD repeat, sterile alpha motif and U-box domain containing 1provided by RGD
    Primary source
    RGD:1359296
    See related
    Ensembl:ENSRNOG00000005990 AllianceGenome:RGD:1359296
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination. Orthologous to human WDSUB1 (WD repeat, sterile alpha motif and U-box domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 58.0), Kidney (RPKM 57.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wdsub1 in Genome Data Viewer
    Location:
    3q21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (64749118..64781525, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (44340415..44370890, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (45924979..45955455, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 Neighboring gene uncharacterized LOC134486097 Neighboring gene uncharacterized LOC108350580 Neighboring gene bromodomain adjacent to zinc finger domain, 2B Neighboring gene ADP-ribosylation factor 4, pseudogene 1 Neighboring gene RNA, U6 small nuclear 22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC108920

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat, SAM and U-box domain-containing protein 1
    Names
    WD repeat, SAM and U-box domain containing 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014179.1 → NP_001014201.1  WD repeat, SAM and U-box domain-containing protein 1

      See identical proteins and their annotated locations for NP_001014201.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089856
      UniProtKB/Swiss-Prot
      Q5FVN8
      UniProtKB/TrEMBL
      A0A8I5Y6I8
      Related
      ENSRNOP00000077591.1, ENSRNOT00000095031.1
      Conserved Domains (4) summary
      cd09505
      Location:328 → 399
      SAM_WDSUB1; SAM domain of WDSUB1 proteins
      cd00200
      Location:4 → 309
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:16 → 52
      7WD40; WD40 repeat [structural motif]
      pfam04564
      Location:404 → 476
      U-box; U-box domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      64749118..64781525 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284111.1 → XP_063140181.1  WD repeat, SAM and U-box domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0H2UHE3, A0A8I5Y6I8

    2. XM_006234211.5 → XP_006234273.1  WD repeat, SAM and U-box domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006234273.1

      UniProtKB/Swiss-Prot
      Q5FVN8
      UniProtKB/TrEMBL
      A0A8I5Y6I8
      Conserved Domains (4) summary
      cd09505
      Location:328 → 399
      SAM_WDSUB1; SAM domain of WDSUB1 proteins
      cd00200
      Location:4 → 309
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:16 → 52
      7WD40; WD40 repeat [structural motif]
      pfam04564
      Location:404 → 476
      U-box; U-box domain

    3. XM_017591892.2 → XP_017447381.1  WD repeat, SAM and U-box domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0H2UHE3, A0A8I5Y6I8
      Related
      ENSRNOP00000008168.6

    4. XM_039105392.2 → XP_038961320.1  WD repeat, SAM and U-box domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      A6JF69
      Conserved Domains (2) summary
      cd00200
      Location:4 → 258
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:16 → 52
      7WD40; WD40 repeat [structural motif]

    5. XM_063284112.1 → XP_063140182.1  WD repeat, SAM and U-box domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      A6JF69
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5FVN8.1 GenPept UniProtKB/Swiss-Prot:Q5FVN8

    Gene LinkOut

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