TRIM17 tripartite motif containing 17 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRIM17provided by HGNC
Official Full Name: tripartite motif containing 17provided by HGNC
Primary source: HGNC:HGNC:13430
See related: Ensembl:ENSG00000162931 MIM:606123; AllianceGenome:HGNC:13430
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RBCC; terf; RNF16
Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein is expressed almost exclusively in the testis, but its function is unknown. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Biased expression in testis (RPKM 5.7), spleen (RPKM 1.3) and 11 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q42.13

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (228407935..228416861, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (227596448..227605374, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (228595636..228604562, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRIM17-mediated ubiquitination and degradation of RBM38 promotes cisplatin resistance in non-small cell lung cancer.
Title: TRIM17-mediated ubiquitination and degradation of RBM38 promotes cisplatin resistance in non-small cell lung cancer.
MiR-1246 is responsible for lung cancer cells-derived exosomes-mediated promoting effects on lung cancer stemness via targeting TRIM17.
Title: MiR-1246 is responsible for lung cancer cells-derived exosomes-mediated promoting effects on lung cancer stemness via targeting TRIM17.
overexpression of TRIM28 or knock-out of TRIM17 reduced BCLA1 protein levels and restored sensitivity of melanoma cells to BRAF-targeted therapy. Therefore, our data describe a molecular rheostat in which two proteins of the TRIM family antagonistically regulate BCL2A1 stability and modulate cell death.
Title: TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1.
data suggest LSD1 largely plays a tumor suppressor role in luminal breast cancer and the oncogenic program associated with LSD1-inhibition may be suppressed via TRIM37-inhibition
Title: LSD1 suppresses invasion, migration and metastasis of luminal breast cancer cells via activation of GATA3 and repression of TRIM37 expression.
deregulation of the TRIM17/TRIM41/ZSCAN21 pathway may be involved in the pathogenesis of Parkinson's disease.
Title: The E3 Ubiquitin Ligases TRIM17 and TRIM41 Modulate α-Synuclein Expression by Regulating ZSCAN21.
TRIM17 promoted the removal of midbodies, remnants of the cell division machinery that are known autophagy targets.
Title: TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation.
NFATc3 interacted in a SUMO-dependent manner with Trim17, an E3 ubiquitin ligase necessary for neuronal apoptosis
Title: Control of neuronal apoptosis by reciprocal regulation of NFATc3 and Trim17.
the E3 ubiquitin ligase terf causes protein degradation of ZWINT and negatively regulates cell proliferation
Title: Terf/TRIM17 stimulates degradation of kinetochore protein ZWINT and regulates cell proliferation.
Observational study of gene-disease association. (HuGE Navigator)
Title: Candidate-gene testing for orphan limb-girdle muscular dystrophies.
terf interacts with TRIM44;TRIM44 inhibited ubiquitination of terf, and thus stabilized the protein.
Title: TRIM44 interacts with and stabilizes terf, a TRIM ubiquitin E3 ligase.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in autophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autoubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase TRIM17

Names: RING finger protein terf; RING-type E3 ubiquitin transferase TRIM17; ring finger protein 16; testis RING finger protein; tripartite motif-containing protein 17

NP_001020111.1

EC 2.3.2.27

NP_001128327.1

EC 2.3.2.27

NP_057186.1

EC 2.3.2.27

XP_006711842.1

EC 2.3.2.27

XP_011542511.1

EC 2.3.2.27

XP_011542512.1

EC 2.3.2.27

XP_011542513.1

EC 2.3.2.27

XP_016856908.1

EC 2.3.2.27

XP_047278034.1

EC 2.3.2.27

XP_047278044.1

EC 2.3.2.27

XP_047278047.1

EC 2.3.2.27

XP_047278054.1

EC 2.3.2.27

XP_047278059.1

EC 2.3.2.27

XP_054192869.1

EC 2.3.2.27

XP_054192870.1

EC 2.3.2.27

XP_054192871.1

EC 2.3.2.27

XP_054192872.1

EC 2.3.2.27

XP_054192873.1

EC 2.3.2.27

XP_054192874.1

EC 2.3.2.27

XP_054192875.1

EC 2.3.2.27

XP_054192876.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024940.3 → NP_001020111.1 E3 ubiquitin-protein ligase TRIM17 isoform 1

See identical proteins and their annotated locations for NP_001020111.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks a segment in the 5' UTR, as compared to variant 1. Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AW770403, BC033788, DA270450

Consensus CDS

CCDS1571.1

UniProtKB/Swiss-Prot

B4DVJ2, Q5VST8, Q9Y577

Related

ENSP00000295033.3, ENST00000295033.7

Conserved Domains (3) summary

cd00021
Location:97 → 134

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd15812
Location:296 → 472

SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)

cd16595
Location:13 → 66

RING-HC_TRIM17_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein TRIM17 and similar proteins
NM_001134855.2 → NP_001128327.1 E3 ubiquitin-protein ligase TRIM17 isoform 3

See identical proteins and their annotated locations for NP_001128327.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and 3' coding region and UTR, compared to variant 1. The encoded protein (isoform 3) has a shorter and distinct C-terminus that lacks a SPRY domain, compared to isoform 1.

Source sequence(s)

AK308774, DC309740

Consensus CDS

CCDS44327.1

UniProtKB/TrEMBL

B7ZAR4

Related

ENSP00000403312.2, ENST00000456946.6

Conserved Domains (2) summary

cd00021
Location:97 → 134

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cl17238
Location:16 → 65

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
NM_016102.4 → NP_057186.1 E3 ubiquitin-protein ligase TRIM17 isoform 1

See identical proteins and their annotated locations for NP_057186.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AW770403, BC033788, DA270450, DB031719

Consensus CDS

CCDS1571.1

UniProtKB/Swiss-Prot

B4DVJ2, Q5VST8, Q9Y577

Related

ENSP00000355659.2, ENST00000366698.7

Conserved Domains (3) summary

cd00021
Location:97 → 134

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd15812
Location:296 → 472

SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)

cd16595
Location:13 → 66

RING-HC_TRIM17_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein TRIM17 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

228407935..228416861 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047422088.1 → XP_047278044.1 E3 ubiquitin-protein ligase TRIM17 isoform X2
XM_011544211.4 → XP_011542513.1 E3 ubiquitin-protein ligase TRIM17 isoform X2

See identical proteins and their annotated locations for XP_011542513.1

Conserved Domains (3) summary

cd00021
Location:70 → 107

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd15812
Location:269 → 445

SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)

cl17238
Location:4 → 38

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
XM_017001419.2 → XP_016856908.1 E3 ubiquitin-protein ligase TRIM17 isoform X3

UniProtKB/TrEMBL

B3KP04, E5RJW6

Related

ENSP00000430468.1, ENST00000479800.1

Conserved Domains (2) summary

cd00021
Location:97 → 134

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cl17238
Location:16 → 65

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
XM_011544210.4 → XP_011542512.1 E3 ubiquitin-protein ligase TRIM17 isoform X1

See identical proteins and their annotated locations for XP_011542512.1

UniProtKB/Swiss-Prot

B4DVJ2, Q5VST8, Q9Y577

Conserved Domains (3) summary

cd00021
Location:97 → 134

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd15812
Location:296 → 472

SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)

cd16595
Location:13 → 66

RING-HC_TRIM17_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein TRIM17 and similar proteins
XM_047422103.1 → XP_047278059.1 E3 ubiquitin-protein ligase TRIM17 isoform X3

UniProtKB/TrEMBL

B3KP04, E5RJW6
XM_006711779.4 → XP_006711842.1 E3 ubiquitin-protein ligase TRIM17 isoform X1

See identical proteins and their annotated locations for XP_006711842.1

UniProtKB/Swiss-Prot

B4DVJ2, Q5VST8, Q9Y577

Conserved Domains (3) summary

cd00021
Location:97 → 134

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd15812
Location:296 → 472

SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)

cd16595
Location:13 → 66

RING-HC_TRIM17_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein TRIM17 and similar proteins
XM_047422098.1 → XP_047278054.1 E3 ubiquitin-protein ligase TRIM17 isoform X3

UniProtKB/TrEMBL

B3KP04, E5RJW6
XM_011544209.4 → XP_011542511.1 E3 ubiquitin-protein ligase TRIM17 isoform X1

See identical proteins and their annotated locations for XP_011542511.1

UniProtKB/Swiss-Prot

B4DVJ2, Q5VST8, Q9Y577

Conserved Domains (3) summary

cd00021
Location:97 → 134

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd15812
Location:296 → 472

SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)

cd16595
Location:13 → 66

RING-HC_TRIM17_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein TRIM17 and similar proteins
XM_047422091.1 → XP_047278047.1 E3 ubiquitin-protein ligase TRIM17 isoform X3

UniProtKB/TrEMBL

B3KP04, E5RJW6
XM_047422078.1 → XP_047278034.1 E3 ubiquitin-protein ligase TRIM17 isoform X1

UniProtKB/Swiss-Prot

B4DVJ2, Q5VST8, Q9Y577

Related

ENSP00000355658.2, ENST00000366697.6

Reference GRCh38.p14 PATCHES

Genomic

NW_018654708.1 Reference GRCh38.p14 PATCHES

Range

1..8060 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

227596448..227605374 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054336897.1 → XP_054192872.1 E3 ubiquitin-protein ligase TRIM17 isoform X2
XM_054336898.1 → XP_054192873.1 E3 ubiquitin-protein ligase TRIM17 isoform X2
XM_054336895.1 → XP_054192870.1 E3 ubiquitin-protein ligase TRIM17 isoform X1

UniProtKB/Swiss-Prot

B4DVJ2, Q5VST8, Q9Y577
XM_054336894.1 → XP_054192869.1 E3 ubiquitin-protein ligase TRIM17 isoform X1

UniProtKB/Swiss-Prot

B4DVJ2, Q5VST8, Q9Y577
XM_054336896.1 → XP_054192871.1 E3 ubiquitin-protein ligase TRIM17 isoform X1

UniProtKB/Swiss-Prot

B4DVJ2, Q5VST8, Q9Y577
XM_054336901.1 → XP_054192876.1 E3 ubiquitin-protein ligase TRIM17 isoform X3

UniProtKB/TrEMBL

B3KP04, E5RJW6
XM_054336900.1 → XP_054192875.1 E3 ubiquitin-protein ligase TRIM17 isoform X3

UniProtKB/TrEMBL

B3KP04, E5RJW6
XM_054336899.1 → XP_054192874.1 E3 ubiquitin-protein ligase TRIM17 isoform X3

UniProtKB/TrEMBL

B3KP04, E5RJW6

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001024941.2: Suppressed sequence

Description

NM_001024941.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.