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    Ugt2a1 UDP glucuronosyltransferase family 2 member A1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 63867, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Ugt2a1provided by RGD
    Official Full Name
    UDP glucuronosyltransferase family 2 member A1provided by RGD
    Primary source
    RGD:69432
    See related
    Ensembl:ENSRNOG00000064759 AllianceGenome:RGD:69432
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ugt2a1p
    Summary
    Predicted to enable glucuronosyltransferase activity. Involved in sensory perception of smell. Predicted to be integral component of membrane. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to several human genes including UGT2A2 (UDP glucuronosyltransferase family 2 member A2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 2.0) See more
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    Genomic context

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    See Ugt2a1 in Genome Data Viewer
    Location:
    14p21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (20797262..20825111)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (20521018..20545934)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (22192970..22217094)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene sulfotransferase family 1D, member 1 Neighboring gene sulfotransferase family 1B member 1 Neighboring gene UDP glucuronosyltransferase family 2 member A3 Neighboring gene kelch repeat and BTB domain-containing protein 8-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The odorant metabolizing enzyme UGT2A1: Immunolocalization and impact of the modulation of its activity on the olfactory response. Neiers F, et al. PLoS One, 2021. PMID 33765098, Free PMC Article
    2. Odorant signal termination by olfactory UDP glucuronosyl transferase. Lazard D, et al. Nature, 1991 Feb 28. PMID 1900353
    3. Human UDP-glucuronosyltransferase UGT2A2: cDNA construction, expression, and functional characterization in comparison with UGT2A1 and UGT2A3. Sneitz N, et al. Pharmacogenet Genomics, 2009 Dec. PMID 19858781, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The odorant metabolizing enzyme UGT2A1: Immunolocalization and impact of the modulation of its activity on the olfactory response.
      Title: The odorant metabolizing enzyme UGT2A1: Immunolocalization and impact of the modulation of its activity on the olfactory response.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables UDP-glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucuronosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucuronosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucuronosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucuronosyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in bile acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in bile acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular glucuronidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular glucuronidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular glucuronidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to toxic substance TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in sensory perception of chemical stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception of chemical stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    UDP-glucuronosyltransferase 2A1
    Names
    UDP glucuronosyltransferase 2 family, polypeptide A1
    UDP glycosyltransferase 2 family, polypeptide A1
    UDPGT 2A1
    UGT-OLF
    NP_071564.2
    XP_038948318.1
    XP_063129641.1
    XP_063129642.1
    XP_063129643.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022228.2 → NP_071564.2  UDP-glucuronosyltransferase 2A1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      P36510
      UniProtKB/TrEMBL
      A6KU27
      Related
      ENSRNOP00000002704.6, ENSRNOT00000002704.7
      Conserved Domains (1) summary
      pfam00201
      Location:21 → 523
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      20797262..20825111
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273572.1 → XP_063129642.1  UDP-glucuronosyltransferase 2A1 isoform X2

      UniProtKB/Swiss-Prot
      P36510
      UniProtKB/TrEMBL
      A6KU27

    2. XM_063273573.1 → XP_063129643.1  UDP-glucuronosyltransferase 2A1 isoform X3

    3. XM_039092390.2 → XP_038948318.1  UDP-glucuronosyltransferase 2A1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GMC7
      Related
      ENSRNOP00000097034.1
      Conserved Domains (1) summary
      pfam00201
      Location:22 → 524
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

    4. XM_063273571.1 → XP_063129641.1  UDP-glucuronosyltransferase 2A1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GMC7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36510.1 GenPept UniProtKB/Swiss-Prot:P36510

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Research Materials
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