Ntsr2 neurotensin receptor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ntsr2provided by RGD
Official Full Name: neurotensin receptor 2provided by RGD
Primary source: RGD:70962
See related: Ensembl:ENSRNOG00000049054 AllianceGenome:RGD:70962
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables identical protein binding activity. Involved in positive regulation of ERK1 and ERK2 cascade. Located in several cellular components, including dendritic shaft; perikaryon; and trans-Golgi network. Orthologous to human NTSR2 (neurotensin receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 70.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 6q16

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (45153095..45159783)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (39424297..39431015)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (41917065..41923780)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Heightened Exploratory Behavior Following Chronic Excessive Ethanol Drinking: Mediation by Neurotensin Receptor Type 2 in the Anterior Paraventricular Thalamus.
Title: Heightened Exploratory Behavior Following Chronic Excessive Ethanol Drinking: Mediation by Neurotensin Receptor Type 2 in the Anterior Paraventricular Thalamus.
Study suggests that NTS1 and NTS2 neurotensin receptor mechanisms appear involved in fear conditioning processes and that agonists for neurotensin receptors may be pursued as novel anxiolytic drugs.
Title: Neurotensin NTS(1) and NTS(2) receptor agonists produce anxiolytic-like effects in the 22-kHz ultrasonic vocalization model in rats.
These results also provide evidence that activation of NTR1 in the RVM produces antinociception through spinal release of norepinephrine (NE) and serotonin, and that activation of NTR2 in the RVM produces antinociception mediated by spinal release of NE.
Title: Neurotensin-produced antinociception in the rostral ventromedial medulla is partially mediated by spinal cord norepinephrine.
Expression and function of NTR2 receptors in rat cerebellar granule cells
Title: Pharmacology and functional properties of NTS2 neurotensin receptors in cerebellar granule cells.
The distribution of NTS2-like immunoreactivity largely exceeded that of neurotensin terminal fields, and some of the highest concentrations of the receptor were found in areas devoid of neurotensinergic inputs.
Title: Immunohistochemical distribution of NTS2 neurotensin receptors in the rat central nervous system.
the rat vNTS2 is a functional receptor that may play a role in NT signaling in mammalian central nervous system
Title: Identification and functional characterization of a 5-transmembrane domain variant isoform of the NTS2 neurotensin receptor in rat central nervous system.
NTS2 is a bona fide NT receptor and that activation of this receptor by NT or NT analogs results in an internalization-dependent activation of the ERK1/2 signaling cascade.
Title: Low-affinity neurotensin receptor (NTS2) signaling: internalization-dependent activation of extracellular signal-regulated kinases 1/2.
NTS2 receptors play a role in the regulation of spinal nociceptive inputs and selective NTS2 agonists may offer new avenues for the treatment of acute pain.
Title: Potent spinal analgesia elicited through stimulation of NTS2 neurotensin receptors.
NTS1/NTS2 heterodimerization affects the intracellular distribution and trafficking of NTS1 by making it more similar to that of NTS2 as witnessed in cells expressing NTS2 alone.
Title: NTS2 modulates the intracellular distribution and trafficking of NTS1 via heterodimerization.

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General gene information

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Markers

RH130505 (e-PCR)
- UniSTS:213789

NoName (e-PCR)
- UniSTS:494148

D6RAT33 (e-PCR)
- UniSTS:122241

NoName (e-PCR)
- UniSTS:489091

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled neurotensin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled neurotensin receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled neurotensin receptor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of membrane potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic shaft	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: neurotensin receptor type 2

Names: NT-R-2; NTR2 receptor; high-affinity levocabastine-sensitive neurotensin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.