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    UBXN10 UBX domain protein 10 [ Homo sapiens (human) ]

    Gene ID: 127733, updated on 5-Mar-2024

    Summary

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    Official Symbol
    UBXN10provided by HGNC
    Official Full Name
    UBX domain protein 10provided by HGNC
    Primary source
    HGNC:HGNC:26354
    See related
    Ensembl:ENSG00000162543 MIM:616783; AllianceGenome:HGNC:26354
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UBXD3
    Summary
    Involved in cilium assembly. Located in cilium. Colocalizes with intraciliary transport particle B. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 9.4), lung (RPKM 3.6) and 16 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    1p36.12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (20183331..20196050)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (20006726..20019694)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (20512589..20522543)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:20468424-20468924 Neighboring gene phospholipase A2 group IIF Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:20474795-20475295 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:20476004-20476630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:20479806-20480357 Neighboring gene uncharacterized LOC117779438 Neighboring gene phospholipase A2 group IIC Neighboring gene ATAC-STARR-seq lymphoblastoid active region 316 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:20511679-20512878 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 317 Neighboring gene uncharacterized LOC105376825 Neighboring gene uncharacterized LOC105376826 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:20537509-20538708

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover. Alexandru G, et al. Cell, 2008 Sep 5. PMID 18775313, Free PMC Article
    2. Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis. Raman M, et al. Nat Cell Biol, 2015 Oct. PMID 26389662, Free PMC Article
    3. LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells. Trepte P, et al. Mol Syst Biol, 2018 Jul 11. PMID 29997244, Free PMC Article
    4. Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins. Tomkins JE, et al. Proteomics, 2018 May. PMID 29513927, Free PMC Article
    5. A Y2H-seq approach defines the human protein methyltransferase interactome. Weimann M, et al. Nat Methods, 2013 Apr. PMID 23455924

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that UBXN10 localizes to cilia in a AAA-ATPase VCP-dependent manner and both VCP and UBXN10 are required for ciliogenesis.
      Title: Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ25429

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of intraciliary transport particle B IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UBX domain-containing protein 10
    Names
    UBX domain containing 3
    UBX domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152376.5 → NP_689589.1  UBX domain-containing protein 10

      See identical proteins and their annotated locations for NP_689589.1

      Status: VALIDATED

      Source sequence(s)
      BX648631, Z98257
      Consensus CDS
      CCDS205.1
      UniProtKB/Swiss-Prot
      Q5R386, Q96LJ8
      Related
      ENSP00000364240.3, ENST00000375099.4
      Conserved Domains (1) summary
      cl25424
      Location:196 → 269
      TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      20183331..20196050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011540699.4 → XP_011539001.1  UBX domain-containing protein 10 isoform X1

      See identical proteins and their annotated locations for XP_011539001.1

      UniProtKB/Swiss-Prot
      Q5R386, Q96LJ8
      Conserved Domains (1) summary
      cl25424
      Location:196 → 269
      TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...

    2. XM_005245742.5 → XP_005245799.1  UBX domain-containing protein 10 isoform X1

      See identical proteins and their annotated locations for XP_005245799.1

      UniProtKB/Swiss-Prot
      Q5R386, Q96LJ8
      Conserved Domains (1) summary
      cl25424
      Location:196 → 269
      TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      20006726..20019694
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334395.1 → XP_054190370.1  UBX domain-containing protein 10 isoform X1

      UniProtKB/Swiss-Prot
      Q5R386, Q96LJ8

    2. XM_054334396.1 → XP_054190371.1  UBX domain-containing protein 10 isoform X1

      UniProtKB/Swiss-Prot
      Q5R386, Q96LJ8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96LJ8.1 GenPept UniProtKB/Swiss-Prot:Q96LJ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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