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    Farp1 FERM, ARH/RhoGEF and pleckstrin domain protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 223254, updated on 4-May-2024

    Summary

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    Official Symbol
    Farp1provided by MGI
    Official Full Name
    FERM, ARH/RhoGEF and pleckstrin domain protein 1provided by MGI
    Primary source
    MGI:MGI:2446173
    See related
    Ensembl:ENSMUSG00000025555 AllianceGenome:MGI:2446173
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cdep
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in several processes, including dendrite morphogenesis; retrograde trans-synaptic signaling by trans-synaptic protein complex; and synapse organization. Predicted to be located in cytosol and dendrite. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Is expressed in lung epithelium; nephron; nervous system; and retina. Orthologous to human FARP1 (FERM, ARH/RhoGEF and pleckstrin domain protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 25.3), CNS E18 (RPKM 22.0) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 E5; 14 64.86 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (121272563..121521156)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (121035168..121283744)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52124 Neighboring gene STARR-seq mESC enhancer starr_37701 Neighboring gene STARR-seq mESC enhancer starr_37702 Neighboring gene importin 5 Neighboring gene RIKEN cDNA B930095G15 gene Neighboring gene STARR-seq mESC enhancer starr_37715 Neighboring gene STARR-seq mESC enhancer starr_37718 Neighboring gene STARR-positive B cell enhancer ABC_E1475 Neighboring gene serine/threonine kinase 24 Neighboring gene STARR-positive B cell enhancer ABC_E478 Neighboring gene STARR-seq mESC enhancer starr_37728 Neighboring gene STARR-seq mESC enhancer starr_37729 Neighboring gene STARR-positive B cell enhancer ABC_E11584 Neighboring gene predicted gene, 33299

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes. Rinschen MM, et al. Cell Rep, 2018 May 22. PMID 29791858, Free PMC Article
    2. The novel synaptogenic protein Farp1 links postsynaptic cytoskeletal dynamics and transsynaptic organization. Cheadle L, et al. J Cell Biol, 2012 Dec 10. PMID 23209303, Free PMC Article
    3. Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca(2+)/CaM) and CaM Kinase II (CaMKII) Binding Partner. Evans PR, et al. J Proteome Res, 2018 Apr 6. PMID 29518331, Free PMC Article
    4. Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome. Li J, et al. Sci Signal, 2016 Aug 9. PMID 27507650
    5. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. Srivastava A, et al. J Biosci, 2020. PMID 32098917

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rac protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in enzyme-linked receptor protein signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of skeletal muscle acetylcholine-gated channel clustering IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in postsynaptic actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of presynapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde trans-synaptic signaling by trans-synaptic protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extrinsic component of postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FERM, ARHGEF and pleckstrin domain-containing protein 1
    Names
    FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived)
    FERM, RhoGEF and pleckstrin domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001425775.1 → NP_001412704.1  FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154618, AC165163, AC167566

    2. NM_001425776.1 → NP_001412705.1  FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154618, AC165163, AC167566

    3. NM_001425777.1 → NP_001412706.1  FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC154618, AC165163, AC167566

    4. NM_001425778.1 → NP_001412707.1  FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC154618, AC165163, AC167566

    5. NM_134082.4 → NP_598843.3  FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_598843.3

      Status: VALIDATED

      Source sequence(s)
      AC154618, AC165163, AC167566
      Consensus CDS
      CCDS37015.1
      UniProtKB/Swiss-Prot
      C4IXU2, F8VPU2
      Related
      ENSMUSP00000026635.7, ENSMUST00000026635.8
      Conserved Domains (6) summary
      smart00295
      Location:41 → 230
      B41; Band 4.1 homologues
      cd00160
      Location:544 → 731
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01220
      Location:756 → 864
      PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
      cd13193
      Location:217 → 337
      FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
      cd13235
      Location:934 → 1031
      PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
      pfam08736
      Location:329 → 371
      FA; FERM adjacent (FA)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      121272563..121521156
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518914.5 → XP_006518977.1  FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006518977.1

      UniProtKB/Swiss-Prot
      C4IXU2, F8VPU2
      Conserved Domains (6) summary
      smart00295
      Location:41 → 230
      B41; Band 4.1 homologues
      cd00160
      Location:544 → 731
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01220
      Location:756 → 864
      PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
      cd13193
      Location:217 → 337
      FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
      cd13235
      Location:934 → 1031
      PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
      pfam08736
      Location:329 → 371
      FA; FERM adjacent (FA)

    2. XM_030247776.2 → XP_030103636.1  FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      C4IXU2, F8VPU2
      Conserved Domains (6) summary
      smart00295
      Location:41 → 230
      B41; Band 4.1 homologues
      cd00160
      Location:544 → 731
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01220
      Location:756 → 864
      PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
      cd13193
      Location:217 → 337
      FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
      cd13235
      Location:934 → 1031
      PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
      pfam08736
      Location:329 → 371
      FA; FERM adjacent (FA)

    3. XM_030247778.2 → XP_030103638.1  FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform X2

      Conserved Domains (6) summary
      smart00295
      Location:41 → 230
      B41; Band 4.1 homologues
      cd00160
      Location:534 → 721
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01220
      Location:746 → 854
      PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
      cd13193
      Location:217 → 337
      FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
      cd13235
      Location:924 → 1021
      PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
      pfam08736
      Location:329 → 371
      FA; FERM adjacent (FA)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F8VPU2.1 GenPept UniProtKB/Swiss-Prot:F8VPU2

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