Chn1 chimerin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Chn1provided by RGD
Official Full Name: chimerin 1provided by RGD
Primary source: RGD:620139
See related: Ensembl:ENSRNOG00000017939 AllianceGenome:RGD:620139
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GTPase activator activity and ephrin receptor binding activity. Predicted to be involved in several processes, including ephrin receptor signaling pathway; motor neuron axon guidance; and regulation of GTPase activity. Human ortholog(s) of this gene implicated in Duane retraction syndrome. Orthologous to human CHN1 (chimerin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 314.3), Lung (RPKM 36.5) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 3q23

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (78917329..79084040, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (58509822..58676462, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (60512360..60668413, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

serum levels decreased significantly as gestation progressed
Title: Expression and regulation of chemerin during rat pregnancy.
signaling via diacylglycerol may regulate the abundance of alpha1-chimaerin under physiological conditions
Title: Rac GTPase-activating protein (Rac GAP) α1-Chimaerin undergoes proteasomal degradation and is stabilized by diacylglycerol signaling in neurons.
identified a new alpha2-chimaerin-dependent signaling mechanism through which EphA4 transduces its signals to the actin cytoskeleton and modulates growth cone morphology
Title: Alpha2-chimaerin interacts with EphA4 and regulates EphA4-dependent growth cone collapse.
These results indicate that active alpha2-chimaerin Rac GAP, Cdk5/p35, and its substrate CRMP-2, are implicated in the dynamics of growth cone guidance initiated through Sema 3A signaling.
Title: Alpha2-chimaerin, cyclin-dependent Kinase 5/p35, and its target collapsin response mediator protein-2 are essential components in semaphorin 3A-induced growth-cone collapse.

Submit: New GeneRIF Correction

General gene information

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Markers

D3Rat39 (e-PCR), detects polymorphism
- UniSTS:227677

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	TAS Traceable Author Statement more info	PubMed
enables ephrin receptor binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phorbol ester receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in ephrin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ephrin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in motor neuron axon guidance	ISO Inferred from Sequence Orthology more info
involved_in motor neuron axon guidance	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of axonogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of small GTPase mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: N-chimaerin

Names: A-chimaerin; N-chimerin; NC; alpha-chimerin; chimerin (chimaerin) 1; rho GTPase-activating protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399177.1 → NP_001386106.1 N-chimaerin isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6A036

Related

ENSRNOP00000082258.1, ENSRNOT00000102625.1
NM_032083.2 → NP_114472.2 N-chimaerin isoform 2

Status: VALIDATED

Source sequence(s)

BC094519, JAXUCZ010000003

UniProtKB/Swiss-Prot

P30337, Q505J4

UniProtKB/TrEMBL

A6HMA4

Conserved Domains (2) summary

cd04372
Location:141 → 334

RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...

cl00040
Location:77 → 135

C1; protein kinase C conserved region 1 (C1 domain) superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

78917329..79084040 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105973.2 → XP_038961901.1 N-chimaerin isoform X2

UniProtKB/TrEMBL

A0A8I6AHR6, A0A8I6ASS0

Related

ENSRNOP00000097347.1

Conserved Domains (3) summary

cd10352
Location:38 → 124

SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins

cd04372
Location:262 → 455

RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...

cd20856
Location:197 → 253

C1_alphaCHN; protein kinase C conserved region 1 (C1 domain) found in alpha-chimaerin and similar proteins
XM_006234386.5 → XP_006234448.1 N-chimaerin isoform X1

UniProtKB/TrEMBL

A0A8I6A036

Conserved Domains (3) summary

cd10352
Location:59 → 145

SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins

cd04372
Location:283 → 476

RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...

pfam00130
Location:223 → 275

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
XM_063284708.1 → XP_063140778.1 N-chimaerin isoform X3

UniProtKB/TrEMBL

A0A8I6A036
XM_063284709.1 → XP_063140779.1 N-chimaerin isoform X4