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    Ttc19 tetratricopeptide repeat domain 19 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691506, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Ttc19provided by RGD
    Official Full Name
    tetratricopeptide repeat domain 19provided by RGD
    Primary source
    RGD:1582808
    See related
    Ensembl:ENSRNOG00000002977 AllianceGenome:RGD:1582808
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311797
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex III assembly. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 2. Orthologous to human TTC19 (tetratricopeptide repeat domain 19). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 199.6), Heart (RPKM 146.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    10q23
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (47469043..47496923)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (46969723..46997607)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (48599321..48627374)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene sperm antigen with calponin homology and coiled-coil domains 1 Neighboring gene selenoprotein W, pseudogene 1 Neighboring gene adenosine A2B receptor Neighboring gene zinc finger, SWIM-type containing 7 Neighboring gene nuclear receptor co-repressor 1 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class L Neighboring gene transmembrane p24 trafficking protein 4, pseudogene 1 Neighboring gene centromere protein V

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in TTC19 cause mitochondrial complex III deficiency and neurological impairment in humans and flies. Ghezzi D, et al. Nat Genet, 2011 Mar. PMID 21278747
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respiratory chain complex III assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex III assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respiratory chain complex III assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial respiratory chain complex III assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in respirasome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tetratricopeptide repeat protein 19, mitochondrial
    Names
    TPR repeat protein 19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109644.2 → NP_001103114.1  tetratricopeptide repeat protein 19, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_001103114.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6ACK4
      Related
      ENSRNOP00000054591.2, ENSRNOT00000057777.3
      Conserved Domains (3) summary
      sd00006
      Location:207 → 242
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:211 → 288
      TPR_12; Tetratricopeptide repeat
      cl14649
      Location:218 → 326
      BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains

    2. NM_001415772.1 → NP_001402701.1  tetratricopeptide repeat protein 19, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      D4A3Z0, D4A6D7
      Related
      ENSRNOP00000083047.1, ENSRNOT00000112760.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      47469043..47496923
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269901.1 → XP_063125971.1  tetratricopeptide repeat protein 19, mitochondrial isoform X1

    2. XM_039086898.2 → XP_038942826.1  tetratricopeptide repeat protein 19, mitochondrial isoform X2

    3. XM_039086899.2 → XP_038942827.1  tetratricopeptide repeat protein 19, mitochondrial isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D4A6D7.1 GenPept UniProtKB/Swiss-Prot:D4A6D7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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