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    Parvb parvin, beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362973, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Parvbprovided by RGD
    Official Full Name
    parvin, betaprovided by RGD
    Primary source
    RGD:1311485
    See related
    Ensembl:ENSRNOG00000055305 AllianceGenome:RGD:1311485
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin binding activity. Predicted to be involved in several processes, including actin cytoskeleton reorganization; lamellipodium assembly; and substrate adhesion-dependent cell spreading. Predicted to be located in plasma membrane. Predicted to be active in several cellular components, including actin cytoskeleton; focal adhesion; and lamellipodium. Orthologous to human PARVB (parvin beta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 182.1), Muscle (RPKM 137.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Parvb in Genome Data Viewer
    Location:
    7q34
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (117240238..117325744)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (115360254..115445767)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (125189827..125275977)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479759 Neighboring gene SAMM50 sorting and assembly machinery component Neighboring gene small nucleolar RNA SNORA48 Neighboring gene parvin, gamma

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. α-Parvin and β-parvin in the rat uterus during decidualisation and uterine receptivity. Nicholson L, et al. Histochem Cell Biol, 2019 May. PMID 30515554
    2. The first CH domain of affixin activates Cdc42 and Rac1 through alphaPIX, a Cdc42/Rac1-specific guanine nucleotide exchanging factor. Mishima W, et al. Genes Cells, 2004 Mar. PMID 15005707
    3. Structural basis for paxillin binding and focal adhesion targeting of β-parvin. Stiegler AL, et al. J Biol Chem, 2012 Sep 21. PMID 22869380, Free PMC Article
    4. ILK, PINCH and parvin: the tIPP of integrin signalling. Legate KR, et al. Nat Rev Mol Cell Biol, 2006 Jan. PMID 16493410
    5. Affixin activates Rac1 via betaPIX in C2C12 myoblast. Matsuda C, et al. FEBS Lett, 2008 Apr 9. PMID 18325335

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell projection assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment or maintenance of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of cell polarity regulating cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lamellipodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in substrate adhesion-dependent cell spreading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    beta-parvin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134780.1 → NP_001128252.1  beta-parvin

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2KB09, A0A8I5Y6N4
      Related
      ENSRNOP00000075605.1, ENSRNOT00000080152.2
      Conserved Domains (1) summary
      pfam00307
      Location:89 → 190
      CH; Calponin homology (CH) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      117240238..117325744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079611.2 → XP_038935539.1  beta-parvin isoform X2

      UniProtKB/TrEMBL
      A0A8I6AS53
      Conserved Domains (2) summary
      cd21336
      Location:51 → 156
      CH_PARVB_rpt1; first calponin homology (CH) domain found in beta-parvin
      cl00030
      Location:198 → 327
      CH_SF; calponin homology (CH) domain superfamily

    2. XM_039079610.2 → XP_038935538.1  beta-parvin isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZR23, A0A8I6AS53
      Related
      ENSRNOP00000080773.1
      Conserved Domains (2) summary
      cd21336
      Location:61 → 166
      CH_PARVB_rpt1; first calponin homology (CH) domain found in beta-parvin
      cl00030
      Location:208 → 337
      CH_SF; calponin homology (CH) domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Other Literature Sources
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