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    PRRC2C proline rich coiled-coil 2C [ Homo sapiens (human) ]

    Gene ID: 23215, updated on 7-Apr-2024

    Summary

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    Official Symbol
    PRRC2Cprovided by HGNC
    Official Full Name
    proline rich coiled-coil 2Cprovided by HGNC
    Primary source
    HGNC:HGNC:24903
    See related
    Ensembl:ENSG00000117523 MIM:617373; AllianceGenome:HGNC:24903
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    XTP2; BAT2D1; BAT2L2; BAT2-iso
    Summary
    Enables protein C-terminus binding activity. Involved in stress granule assembly. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bone marrow (RPKM 24.0), lymph node (RPKM 17.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    1q24.3
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (171485530..171593511)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (170841969..170949975)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (171454669..171562650)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CYCS pseudogene 53 Neighboring gene small nucleolar RNA U13 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:171454474-171455222 Neighboring gene RNA, 7SL, cytoplasmic 425, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr1:171475977-171476512 Neighboring gene U6 spliceosomal RNA Neighboring gene ReSE screen-validated silencer GRCh37_chr1:171489309-171489479 Neighboring gene myocilin opposite strand Neighboring gene MPRA-validated peak453 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:171613996-171614502 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:171614503-171615009 Neighboring gene myocilin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. KIAA1096, a gene on chromosome 1q, is amplified and overexpressed in bladder cancer. Huang WC, et al. DNA Cell Biol, 2002 Oct. PMID 12443540
    2. Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line. Sun NN, et al. Toxicol Ind Health, 2003 Oct. PMID 15747776
    3. The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing. Miele A, et al. J Cell Biochem, 2007 Sep 1. PMID 17577209
    4. Proteome analysis of the HIV-1 Gag interactome. Engeland CE, et al. Virology, 2014 Jul. PMID 25010285
    5. The N-terminal domain of the Schaaf-Yang syndrome protein MAGEL2 likely has a role in RNA metabolism. Sanderson MR, et al. J Biol Chem, 2021 Aug. PMID 34265304, Free PMC Article

    See all (105) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    2. The KIAA1096 gene is located at 1q23-24 with no overexpression or amplification in normal urothelium, but was significantly upregulated in 30% of tumors.
      Title: KIAA1096, a gene on chromosome 1q, is amplified and overexpressed in bladder cancer.
    3. 10 genes were down-regulated following treatment of the T-ALL cells with 0.15 and 1.5 microg/mL of metal ores at 72 h
      Title: Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Cellular biotinylated proline-rich coiled-coil 2C (PRRC2C) protein is incorporated into HIV-1 Gag virus-like particles PubMed
    gag Interaction of HIV-1 Gag with proline-rich coiled-coil 2C (PRRC2C, BAT2L2) is identified in a series of six affinity purification/mass spectrometry screens PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hematopoietic progenitor cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in stress granule assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic stress granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in membrane HDA PubMed 

    General protein information

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    Preferred Names
    protein PRRC2C
    Names
    BAT2 domain containing 1
    BAT2 domain-containing protein 1
    HBV X-transactivated gene 2 protein
    HBV XAg-transactivated protein 2
    HBxAg transactivated protein 2
    HLA-B-associated transcript 2-like 2
    proline-rich and coiled-coil-containing protein 2C
    protein BAT2-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001387844.1 → NP_001374773.1  protein PRRC2C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL021579, AL049762, Z98750
      Consensus CDS
      CCDS91104.1
      Related
      ENSP00000495867.2, ENST00000647382.2
      Conserved Domains (2) summary
      PTZ00449
      Location:931 → 1309
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam07001
      Location:1 → 162
      BAT2_N; BAT2 N-terminus

    2. NM_015172.4 → NP_055987.2  protein PRRC2C isoform 1

      See identical proteins and their annotated locations for NP_055987.2

      Status: VALIDATED

      Source sequence(s)
      AF488829, AL133635, AL162004, BC001260, CB158511
      Consensus CDS
      CCDS1296.2
      UniProtKB/Swiss-Prot
      Q9Y520
      Related
      ENSP00000343629.4, ENST00000338920.8
      Conserved Domains (1) summary
      pfam07001
      Location:1 → 160
      BAT2_N; BAT2 N-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      171485530..171593511
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005245020.3 → XP_005245077.1  protein PRRC2C isoform X6

      Conserved Domains (2) summary
      pfam09606
      Location:2258 → 2642
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam07001
      Location:1 → 162
      BAT2_N; BAT2 N-terminus

    2. XM_005245015.3 → XP_005245072.1  protein PRRC2C isoform X1

      Conserved Domains (2) summary
      pfam09606
      Location:2258 → 2642
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam07001
      Location:1 → 162
      BAT2_N; BAT2 N-terminus

    3. XM_005245025.3 → XP_005245082.1  protein PRRC2C isoform X10

      Conserved Domains (2) summary
      pfam09606
      Location:2258 → 2642
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam07001
      Location:1 → 162
      BAT2_N; BAT2 N-terminus

    4. XM_005245023.3 → XP_005245080.1  protein PRRC2C isoform X8

      Conserved Domains (2) summary
      pfam09606
      Location:2258 → 2642
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam07001
      Location:1 → 162
      BAT2_N; BAT2 N-terminus

    5. XM_005245028.3 → XP_005245085.1  protein PRRC2C isoform X13

      Conserved Domains (2) summary
      pfam09606
      Location:2258 → 2642
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam07001
      Location:1 → 162
      BAT2_N; BAT2 N-terminus

    6. XM_005245027.3 → XP_005245084.1  protein PRRC2C isoform X12

      Conserved Domains (2) summary
      pfam09606
      Location:2258 → 2642
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam07001
      Location:1 → 162
      BAT2_N; BAT2 N-terminus

    7. XM_017000761.2 → XP_016856250.1  protein PRRC2C isoform X7

    8. XM_005245026.3 → XP_005245083.1  protein PRRC2C isoform X11

      Conserved Domains (1) summary
      pfam07001
      Location:1 → 162
      BAT2_N; BAT2 N-terminus

    9. XM_005245024.3 → XP_005245081.1  protein PRRC2C isoform X9

      UniProtKB/TrEMBL
      E7EPN9
      Related
      ENSP00000356716.3, ENST00000367742.7
      Conserved Domains (1) summary
      pfam07001
      Location:1 → 162
      BAT2_N; BAT2 N-terminus

    10. XM_047415746.1 → XP_047271702.1  protein PRRC2C isoform X15

    11. XM_005245029.3 → XP_005245086.1  protein PRRC2C isoform X14

      Conserved Domains (1) summary
      pfam07001
      Location:1 → 162
      BAT2_N; BAT2 N-terminus

    12. XM_005245018.4 → XP_005245075.1  protein PRRC2C isoform X3

      Conserved Domains (2) summary
      pfam09606
      Location:2253 → 2637
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam07001
      Location:1 → 157
      BAT2_N; BAT2 N-terminus

    13. XM_005245016.6 → XP_005245073.1  protein PRRC2C isoform X2

      Conserved Domains (2) summary
      pfam09606
      Location:2256 → 2640
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam07001
      Location:1 → 160
      BAT2_N; BAT2 N-terminus

    14. XM_006711238.5 → XP_006711301.1  protein PRRC2C isoform X4

      See identical proteins and their annotated locations for XP_006711301.1

      UniProtKB/Swiss-Prot
      Q05DM8, Q49A39, Q6PD54, Q9H2N2, Q9HA05, Q9NSM8, Q9NXL3, Q9UF29, Q9UPQ6, Q9Y520
      Conserved Domains (1) summary
      pfam07001
      Location:1 → 160
      BAT2_N; BAT2 N-terminus

    15. XM_017000760.3 → XP_016856249.1  protein PRRC2C isoform X5

    16. XM_047415747.1 → XP_047271703.1  protein PRRC2C isoform X16

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      170841969..170949975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054335383.1 → XP_054191358.1  protein PRRC2C isoform X6

    2. XM_054335378.1 → XP_054191353.1  protein PRRC2C isoform X1

    3. XM_054335387.1 → XP_054191362.1  protein PRRC2C isoform X10

    4. XM_054335385.1 → XP_054191360.1  protein PRRC2C isoform X8

    5. XM_054335390.1 → XP_054191365.1  protein PRRC2C isoform X13

    6. XM_054335389.1 → XP_054191364.1  protein PRRC2C isoform X12

    7. XM_054335384.1 → XP_054191359.1  protein PRRC2C isoform X7

    8. XM_054335388.1 → XP_054191363.1  protein PRRC2C isoform X11

    9. XM_054335386.1 → XP_054191361.1  protein PRRC2C isoform X9

      UniProtKB/TrEMBL
      E7EPN9

    10. XM_054335392.1 → XP_054191367.1  protein PRRC2C isoform X15

    11. XM_054335391.1 → XP_054191366.1  protein PRRC2C isoform X14

    12. XM_054335380.1 → XP_054191355.1  protein PRRC2C isoform X3

    13. XM_054335379.1 → XP_054191354.1  protein PRRC2C isoform X2

    14. XM_054335381.1 → XP_054191356.1  protein PRRC2C isoform X4

      UniProtKB/Swiss-Prot
      Q05DM8, Q49A39, Q6PD54, Q9H2N2, Q9HA05, Q9NSM8, Q9NXL3, Q9UF29, Q9UPQ6, Q9Y520

    15. XM_054335382.1 → XP_054191357.1  protein PRRC2C isoform X5

    16. XM_054335393.1 → XP_054191368.1  protein PRRC2C isoform X16

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y520.4 GenPept UniProtKB/Swiss-Prot:Q9Y520

    Gene LinkOut

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