VIM-AS1 VIM antisense RNA 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: VIM-AS1provided by HGNC
Official Full Name: VIM antisense RNA 1provided by HGNC
Primary source: HGNC:HGNC:44879
See related: Ensembl:ENSG00000229124 MIM:619982; AllianceGenome:HGNC:44879
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression: Broad expression in fat (RPKM 310.7), ovary (RPKM 265.1) and 22 other tissues See more
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Genomic context

Location:: 10p13

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (17214239..17229985, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (17232777..17248530, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (17256238..17271984, complement)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

VIMAS1 promotes proliferation and drives enzalutamide resistance in prostate cancer via IGF2BP2mediated HMGCS1 mRNA stabilization.
Title: VIM‑AS1 promotes proliferation and drives enzalutamide resistance in prostate cancer via IGF2BP2‑mediated HMGCS1 mRNA stabilization.
Clinical significance of Vimentin Antisense RNA 1 and its correlation with other epithelial to mesenchymal transition markers in oral cancers.
Title: Clinical significance of Vimentin Antisense RNA 1 and its correlation with other epithelial to mesenchymal transition markers in oral cancers.
lncRNA VIMAS1 promotes cell proliferation, metastasis and epithelialmesenchymal transition by activating the Wnt/betacatenin pathway in gastric cancer.
Title: lncRNA VIM‑AS1 promotes cell proliferation, metastasis and epithelial‑mesenchymal transition by activating the Wnt/β‑catenin pathway in gastric cancer.
Knockdown of long non-coding RNA VIM-AS1 inhibits glioma cell proliferation and migration, and increases the cell apoptosis via modulation of WEE1 targeted by miR-105-5p.
Title: Knockdown of long non-coding RNA VIM-AS1 inhibits glioma cell proliferation and migration, and increases the cell apoptosis via modulation of WEE1 targeted by miR-105-5p.
Long non-coding RNA VIM Antisense RNA 1 (VIM-AS1) sponges microRNA-29 to participate in diabetic retinopathy.
Title: Long non-coding RNA VIM Antisense RNA 1 (VIM-AS1) sponges microRNA-29 to participate in diabetic retinopathy.
lncRNA VIM-AS1 and lncRNA CTBP1-AS2 expression levels are associated with type 2 diabetes susceptibility.
Title: Clinical significance of long noncoding RNA VIM-AS1 and CTBP1-AS2 expression in type 2 diabetes.
lncRNA VIM-AS1 was overexpressed in prostate cancer (PCa) tissues and cell lines and promoted PCa proliferation and metastasis via epithelial-mesenchymal transition through regulating vimentin, which might provide a novel target for the diagnosis and therapy for PCa.
Title: Long non-coding RNA VIM-AS1 promotes prostate cancer growth and invasion by regulating epithelial-mesenchymal transition.
VIM-AS1 was significantly upregulated in high-grade colorectal cancer.
Title: Long noncoding RNA VIM-AS1 promotes colorectal cancer progression and metastasis by inducing EMT.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Discovery and refinement of loci associated with lipid levels. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See studies and variants in dbVar

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General gene information

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NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

NR_108060.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon and contains two alternate 5' exons, resulting in a shorter transcript, compared to variant 1.

Source sequence(s)

AL133415, BG492614, H08157

Related

ENST00000437232.5
NR_108061.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript.

Source sequence(s)

AL133415, BG492614, BM923888, H08157

Related

ENST00000605833.2