mcm5.L minichromosome maintenance complex component 5 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: mcm5.L
Official Full Name: minichromosome maintenance complex component 5 L homeolog
Primary source: Xenbase:XB-GENE-6256510
Locus tag: XELAEV_18023542mg
See related: EnsemblRapid:ENSXLAG00005034620
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: mcm5; cdc46; xmcm5; mcm5-a; mcm5-b; cdc46-a
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Genomic context

Location:: chromosome: 4L

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4L	NC_054377.1 (112738339..112750653)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4L	NC_030730.1 (107485020..107497337)

Chromosome 4L - NC_054377.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables 3'-5' DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
contributes_to ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA replication origin binding	IEA Inferred from Electronic Annotation more info
contributes_to chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA helicase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA duplex unwinding	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA replication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA replication initiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA unwinding involved in DNA replication	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within double-strand break repair via break-induced replication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within premeiotic DNA replication	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated DNA replication initiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of CMG complex	IDA Inferred from Direct Assay more info	PubMed
part_of MCM complex	IDA Inferred from Direct Assay more info	PubMed
part_of MCM complex	IEA Inferred from Electronic Annotation more info
part_of MCM complex	IPI Inferred from Physical Interaction more info	PubMed
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA replication licensing factor mcm5-A

Names: CDC46 homolog A; CDC46p; MCM5 minichromosome maintenance deficient 5, cell division cycle 46; p92; xCDC46-A; xMCM5-A

NP_001080893.1

EC 3.6.4.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087424.1 → NP_001080893.1 DNA replication licensing factor mcm5-A

See identical proteins and their annotated locations for NP_001080893.1

Status: PROVISIONAL

Source sequence(s)

U44048

UniProtKB/Swiss-Prot

P55862, Q5D0A3

UniProtKB/TrEMBL

A0A974D672

Related

ENSXLAP00005103593.1, ENSXLAT00005105598.1

Conserved Domains (3) summary

smart00350
Location:134 → 650

MCM; minichromosome maintenance proteins

pfam14551
Location:35 → 154

MCM_N; MCM N-terminal domain

cl21455
Location:377 → 515

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases