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    USP22 ubiquitin specific peptidase 22 [ Homo sapiens (human) ]

    Gene ID: 23326, updated on 5-May-2024

    Summary

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    Official Symbol
    USP22provided by HGNC
    Official Full Name
    ubiquitin specific peptidase 22provided by HGNC
    Primary source
    HGNC:HGNC:12621
    See related
    Ensembl:ENSG00000124422 MIM:612116; AllianceGenome:HGNC:12621
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    USP3L
    Summary
    Enables enzyme binding activity; nuclear receptor coactivator activity; and thiol-dependent deubiquitinase. Contributes to H4 histone acetyltransferase activity. Involved in positive regulation of mitotic cell cycle; positive regulation of transcription, DNA-templated; and protein modification by small protein conjugation or removal. Part of SAGA complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in brain (RPKM 54.0), ovary (RPKM 38.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See USP22 in Genome Data Viewer
    Location:
    17p11.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (20999596..21043419, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (20948437..20992181, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (20902909..20946324, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CCDC144NL antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:20811295-20811890 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8310 Neighboring gene ribonuclease H1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:20841589-20842090 Neighboring gene uncharacterized LOC124900389 Neighboring gene Sharpr-MPRA regulatory region 15661 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:20845395-20845894 Neighboring gene uncharacterized LOC339260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11874 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11875 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11876 Neighboring gene SPECC1 pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:20901079-20901896 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:20937215-20937716 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8311 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:20946145-20947094 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:20947095-20948042 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:20954728-20955314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11877 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:20970211-20970711 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:20978550-20979050 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:20987896-20989095 Neighboring gene long intergenic non-protein coding RNA 1563 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr17:21002173-21002789 and GRCh37_chr17:21002790-21003407 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:21011664-21012527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11879 Neighboring gene dehydrogenase/reductase 7B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Immune Evasion and Drug Resistance Mediated by USP22 in Cancer: Novel Targets and Mechanisms. Guo J, et al. Front Immunol, 2022. PMID 35935969, Free PMC Article
    2. Targeting USP22 with miR‑30‑5p to inhibit the hypoxia‑induced expression of PD‑L1 in lung adenocarcinoma cells. Hua X, et al. Oncol Rep, 2021 Oct. PMID 34396448
    3. The SAGA complex regulates early steps in transcription via its deubiquitylase module subunit USP22. Stanek TJ, et al. EMBO J, 2021 Aug 16. PMID 34155658, Free PMC Article
    4. USP22 regulates the formation and function of placental vasculature during the development of fetal growth restriction. Liu Z, et al. Placenta, 2021 Aug. PMID 34130183
    5. USP22 positively modulates ERα action via its deubiquitinase activity in breast cancer. Wang S, et al. Cell Death Differ, 2020 Nov. PMID 32494025, Free PMC Article

    See all (171) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. USP22 supports the aggressive behavior of basal-like breast cancer by stimulating cellular respiration.
      Title: USP22 supports the aggressive behavior of basal-like breast cancer by stimulating cellular respiration.
    2. ADAM9 deubiquitination induced by USP22 suppresses proliferation, migration, invasion, and epithelial-mesenchymal transition of trophoblast cells in preeclampsia.
      Title: ADAM9 deubiquitination induced by USP22 suppresses proliferation, migration, invasion, and epithelial-mesenchymal transition of trophoblast cells in preeclampsia.
    3. USP22-JMJD8 axis promotes Lenvatinib resistance in hepatocellular carcinoma.
      Title: USP22-JMJD8 axis promotes Lenvatinib resistance in hepatocellular carcinoma.
    4. USP22 upregulates ZEB1-mediated VEGFA transcription in hepatocellular carcinoma.
      Title: USP22 upregulates ZEB1-mediated VEGFA transcription in hepatocellular carcinoma.
    5. Transcription factor AP2 enhances malignancy of non-small cell lung cancer through upregulation of USP22 gene expression.
      Title: Transcription factor AP2 enhances malignancy of non-small cell lung cancer through upregulation of USP22 gene expression.
    6. Immune Evasion and Drug Resistance Mediated by USP22 in Cancer: Novel Targets and Mechanisms.
      Title: Immune Evasion and Drug Resistance Mediated by USP22 in Cancer: Novel Targets and Mechanisms.
    7. USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING.
      Title: USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING.
    8. USP22 regulates lipidome accumulation by stabilizing PPARgamma in hepatocellular carcinoma.
      Title: USP22 regulates lipidome accumulation by stabilizing PPARγ in hepatocellular carcinoma.
    9. Upregulation of USP22 and ABCC1 during Sorafenib Treatment of Hepatocellular Carcinoma Contribute to Development of Resistance.
      Title: Upregulation of USP22 and ABCC1 during Sorafenib Treatment of Hepatocellular Carcinoma Contribute to Development of Resistance.
    10. USP22-mediated deubiquitination of PTEN inhibits pancreatic cancer progression by inducing p21 expression.
      Title: USP22-mediated deubiquitination of PTEN inhibits pancreatic cancer progression by inducing p21 expression.
    Submit: New GeneRIF Correction See all GeneRIFs (108)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1063

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to cysteine-type deubiquitinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables histone H2A deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H2B deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to histone H4 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear receptor coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryo development ending in birth or egg hatching NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of type I interferon production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein deubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of RNA splicing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SAGA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SAGA complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in cytoplasm IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    part_of transcription factor TFTC complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 22
    Names
    deubiquitinating enzyme 22
    ubiquitin specific protease 22
    ubiquitin thioesterase 22
    ubiquitin thiolesterase 22
    ubiquitin-specific processing protease 22
    NP_056091.1
    XP_005256632.1
    XP_047291659.1
    XP_054171598.1
    XP_054171599.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015276.2 → NP_056091.1  ubiquitin carboxyl-terminal hydrolase 22

      See identical proteins and their annotated locations for NP_056091.1

      Status: VALIDATED

      Source sequence(s)
      AB028986, AL110213, BX640815
      Consensus CDS
      CCDS42285.1
      UniProtKB/Swiss-Prot
      A0JNS3, Q2NLE2, Q6MZY4, Q8TBS8, Q96IW5, Q9UPT9
      Related
      ENSP00000261497.4, ENST00000261497.9
      Conserved Domains (2) summary
      cd02660
      Location:176 → 518
      Peptidase_C19D; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam02148
      Location:63 → 123
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      20999596..21043419 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005256575.3 → XP_005256632.1  ubiquitin carboxyl-terminal hydrolase 22 isoform X1

      See identical proteins and their annotated locations for XP_005256632.1

      Conserved Domains (2) summary
      cd02660
      Location:71 → 413
      Peptidase_C19D; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:70 → 412
      UCH; Ubiquitin carboxyl-terminal hydrolase

    2. XM_047435703.1 → XP_047291659.1  ubiquitin carboxyl-terminal hydrolase 22 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      20948437..20992181 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315623.1 → XP_054171598.1  ubiquitin carboxyl-terminal hydrolase 22 isoform X1

    2. XM_054315624.1 → XP_054171599.1  ubiquitin carboxyl-terminal hydrolase 22 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UPT9.2 GenPept UniProtKB/Swiss-Prot:Q9UPT9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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