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    Alg12 ALG12, alpha-1,6-mannosyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315212, updated on 2-May-2024

    Summary

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    Official Symbol
    Alg12provided by RGD
    Official Full Name
    ALG12, alpha-1,6-mannosyltransferaseprovided by RGD
    Primary source
    RGD:1304826
    See related
    Ensembl:ENSRNOG00000004591 AllianceGenome:RGD:1304826
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable alpha-1,6-mannosyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Predicted to act upstream of or within dolichol-linked oligosaccharide biosynthetic process. Predicted to be located in endoplasmic reticulum lumen. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ig. Orthologous to human ALG12 (ALG12 alpha-1,6-mannosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 59.8), Kidney (RPKM 59.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Alg12 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (121774796..121789175, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (119895112..119909488, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (129798663..129812677, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547254 Neighboring gene zinc finger, BED-type containing 4 Neighboring gene cysteine-rich with EGF-like domains 2 Neighboring gene transfer RNA leucine (anticodon AAG) 11 Neighboring gene Pim-3 proto-oncogene, serine/threonine kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Congenital disorders of glycosylation type Ig is defined by a deficiency in dolichyl-P-mannose:Man7GlcNAc2-PP-dolichyl mannosyltransferase. Chantret I, et al. J Biol Chem, 2002 Jul 12. PMID 11983712
    2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-1,6-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within dolichol-linked oligosaccharide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dolichol-linked oligosaccharide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase
    Names
    alpha-1,6-mannosyltransferase ALG12
    asparagine-linked glycosylation 12 homolog (yeast, alpha-1,6-mannosyltransferase)
    asparagine-linked glycosylation 12, alpha-1,6-mannosyltransferase
    NP_001101574.2
    XP_017450363.1
    XP_017450364.1
    XP_017450365.1
    XP_017450366.1
    XP_038935231.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108104.2 → NP_001101574.2  dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase precursor

      See identical proteins and their annotated locations for NP_001101574.2

      Status: VALIDATED

      Source sequence(s)
      BC161934, BF409974, FM050024
      UniProtKB/TrEMBL
      B1WBY3
      Related
      ENSRNOP00000061731.1, ENSRNOT00000065848.2
      Conserved Domains (1) summary
      cl21590
      Location:17 → 405
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      121774796..121789175 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594876.3 → XP_017450365.1  dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase isoform X1

      UniProtKB/TrEMBL
      B1WBY3
      Conserved Domains (1) summary
      cl21590
      Location:17 → 405
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    2. XM_017594874.3 → XP_017450363.1  dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase isoform X1

      UniProtKB/TrEMBL
      B1WBY3
      Conserved Domains (1) summary
      cl21590
      Location:17 → 405
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    3. XM_017594877.3 → XP_017450366.1  dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase isoform X1

      UniProtKB/TrEMBL
      B1WBY3
      Conserved Domains (1) summary
      cl21590
      Location:17 → 405
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    4. XM_017594875.3 → XP_017450364.1  dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase isoform X1

      UniProtKB/TrEMBL
      B1WBY3
      Conserved Domains (1) summary
      cl21590
      Location:17 → 405
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    5. XM_039079303.2 → XP_038935231.1  dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase isoform X1

      UniProtKB/TrEMBL
      B1WBY3
      Conserved Domains (1) summary
      cl21590
      Location:17 → 405
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version

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