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    Ranbp10 RAN binding protein 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361396, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Ranbp10provided by RGD
    Official Full Name
    RAN binding protein 10provided by RGD
    Primary source
    RGD:1311587
    See related
    Ensembl:ENSRNOG00000018000 AllianceGenome:RGD:1311587
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311587
    Summary
    Predicted to enable beta-tubulin binding activity; guanyl-nucleotide exchange factor activity; and small GTPase binding activity. Predicted to be involved in cell surface receptor signaling pathway and cytoskeleton organization. Predicted to act upstream of or within microtubule cytoskeleton organization. Predicted to be located in microtubule cytoskeleton. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human RANBP10 (RAN binding protein 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 242.3), Thymus (RPKM 69.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ranbp10 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (50565924..50626720, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (33656046..33716864, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (37734662..37795360, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene Gfo/Idh/MocA-like oxidoreductase domain containing 2 Neighboring gene small nuclear ribonucleoprotein polypeptide G, pseudogene 2 Neighboring gene uncharacterized LOC134483349 Neighboring gene uncharacterized LOC108348930 Neighboring gene translin-associated factor X interacting protein 1 Neighboring gene centromere protein T Neighboring gene THAP domain containing 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules. Schulze H, et al. J Biol Chem, 2008 May 16. PMID 18347012, Free PMC Article
    2. The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation. Lampert F, et al. Elife, 2018 Jun 18. PMID 29911972, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ran-binding protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135875.1 → NP_001129347.1  ran-binding protein 10

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A6IYS3
      Conserved Domains (5) summary
      smart00667
      Location:285 → 312
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:319 → 375
      CTLH; C-terminal to LisH motif
      smart00757
      Location:535 → 632
      CRA; CT11-RanBPM
      pfam10607
      Location:319 → 373
      CLTH; CTLH/CRA C-terminal to LisH motif domain
      cd12909
      Location:105 → 247
      SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      50565924..50626720 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278126.1 → XP_063134196.1  ran-binding protein 10 isoform X3

    2. XM_039097833.2 → XP_038953761.1  ran-binding protein 10 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AKP2
      Conserved Domains (4) summary
      smart00667
      Location:299 → 326
      LisH; Lissencephaly type-1-like homology motif
      smart00757
      Location:565 → 662
      CRA; CT11-RanBPM
      pfam10607
      Location:333 → 387
      CLTH; CTLH/CRA C-terminal to LisH motif domain
      cl02614
      Location:175 → 261
      SPRY; SPRY domain

    3. XM_017601317.3 → XP_017456806.2  ran-binding protein 10 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AKP2, D3Z7Z5
      Related
      ENSRNOP00000024891.6
      Conserved Domains (4) summary
      smart00667
      Location:355 → 382
      LisH; Lissencephaly type-1-like homology motif
      smart00757
      Location:621 → 718
      CRA; CT11-RanBPM
      cd12909
      Location:175 → 317
      SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10
      pfam10607
      Location:389 → 443
      CLTH; CTLH/CRA C-terminal to LisH motif domain

    4. XM_039097835.2 → XP_038953763.1  ran-binding protein 10 isoform X5

      Conserved Domains (4) summary
      smart00667
      Location:126 → 153
      LisH; Lissencephaly type-1-like homology motif
      smart00757
      Location:392 → 489
      CRA; CT11-RanBPM
      pfam10607
      Location:160 → 214
      CLTH; CTLH/CRA C-terminal to LisH motif domain
      cl02614
      Location:4 → 88
      SPRY; SPRY domain

    5. XM_039097834.2 → XP_038953762.1  ran-binding protein 10 isoform X4

      Conserved Domains (3) summary
      smart00667
      Location:355 → 382
      LisH; Lissencephaly type-1-like homology motif
      cd12909
      Location:175 → 317
      SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10
      pfam10607
      Location:389 → 443
      CLTH; CTLH/CRA C-terminal to LisH motif domain
    Nucleotide Protein Strain
    Heading Accession and Version

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