Arid1b AT-rich interaction domain 1B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arid1bprovided by MGI
Official Full Name: AT-rich interaction domain 1Bprovided by MGI
Primary source: MGI:MGI:1926129
See related: Ensembl:ENSMUSG00000069729 AllianceGenome:MGI:1926129
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ardi1b; BAF250B; mKIAA1235; 8030481M12; 9330189K18Rik; B230217J03Rik
Summary: Predicted to enable DNA binding activity. Predicted to contribute to nucleosome binding activity. Acts upstream of or within dendritic cell dendrite assembly; dendritic spine development; and neuron-neuron synaptic transmission. Located in nucleus. Part of nBAF complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study Coffin-Siris syndrome 1 and autism spectrum disorder. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome; Coffin-Siris syndrome 1; intellectual disability; lung non-small cell carcinoma; and neuroblastoma. Orthologous to human ARID1B (AT-rich interaction domain 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 12.5), ovary adult (RPKM 11.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A1; 17 2.83 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (5044481..5397931)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (4994297..5347656)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dissecting the role of SWI/SNF component ARID1B in steady-state hematopoiesis.
Title: Dissecting the role of SWI/SNF component ARID1B in steady-state hematopoiesis.
ARID1B blocks methionine-stimulated mTOR activation to inhibit milk fat and protein synthesis in and proliferation of mouse mammary epithelial cells.
Title: ARID1B blocks methionine-stimulated mTOR activation to inhibit milk fat and protein synthesis in and proliferation of mouse mammary epithelial cells.
Early postnatal serotonin modulation prevents adult-stage deficits in Arid1b-deficient mice through synaptic transcriptional reprogramming.
Title: Early postnatal serotonin modulation prevents adult-stage deficits in Arid1b-deficient mice through synaptic transcriptional reprogramming.
Differential roles of ARID1B in excitatory and inhibitory neural progenitors in the developing cortex.
Title: Differential roles of ARID1B in excitatory and inhibitory neural progenitors in the developing cortex.
Autism-associated miR-873 regulates ARID1B, SHANK3 and NRXN2 involved in neurodevelopment.
Title: Autism-associated miR-873 regulates ARID1B, SHANK3 and NRXN2 involved in neurodevelopment.
Arid1b haploinsufficiency in parvalbumin- or somatostatin-expressing interneurons leads to distinct ASD-like and ID-like behavior.
Title: Arid1b haploinsufficiency in parvalbumin- or somatostatin-expressing interneurons leads to distinct ASD-like and ID-like behavior.
Genome-wide gene expression patterns in Arid1b hKO mice were similar to those in Autism spectrum disorder (ASD)patients and Chd8-haploinsufficient mice, an ASD model, and to developmental changes in gene expression in fast-spiking cells in the mouse brain. Our results suggest that Arid1b haploinsufficiency causes ASD-like phenotypes in mice.
Title: Arid1b Haploinsufficiency Causes Abnormal Brain Gene Expression and Autism-Related Behaviors in Mice.
In the brain, Arid1b haploinsufficiency resulted in changes in the expression of SWI/SNF-regulated genes implicated in neuropsychiatric disorders.
Title: Arid1b haploinsufficient mice reveal neuropsychiatric phenotypes and reversible causes of growth impairment.
STAT3/Arid1b/beta-catenin pathway is driving neurofibroma initiation.
Title: Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation.
The patterns of expression of ARID1A and ARID1B genes through various mouse embryonic stages, was examined.
Title: Dynamics of expression of ARID1A and ARID1B subunits in mouse embryos and in cells during the cell cycle.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Gene trapped (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:224911

D17Jcs97 (e-PCR), detects polymorphism
- UniSTS:259239

STS-T31821 (e-PCR)
- UniSTS:25009

AI836955 (e-PCR)
- UniSTS:180955

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to nucleosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin remodeling	IC Inferred by Curator more info	PubMed
involved_in chromatin remodeling	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within dendritic cell dendrite assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dendritic spine development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron-neuron synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of double-strand break repair	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of myoblast differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of G0 to G1 transition	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of G1/S transition of mitotic cell cycle	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of mitotic metaphase/anaphase transition	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of nucleotide-excision repair	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of SWI/SNF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SWI/SNF complex	ISO Inferred from Sequence Orthology more info
part_of SWI/SNF complex	NAS Non-traceable Author Statement more info	PubMed
part_of SWI/SNF superfamily-type complex	IDA Inferred from Direct Assay more info	PubMed
part_of bBAF complex	NAS Non-traceable Author Statement more info	PubMed
part_of brahma complex	NAS Non-traceable Author Statement more info	PubMed
part_of chromatin	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of nBAF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nBAF complex	IDA Inferred from Direct Assay more info	PubMed
part_of nBAF complex	NAS Non-traceable Author Statement more info	PubMed
part_of npBAF complex	NAS Non-traceable Author Statement more info	PubMed
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: AT-rich interactive domain-containing protein 1B

Names: ARID domain-containing protein 1B; AT rich interactive domain 1B (SWI-like); AT rich interactive domain 1B (Swi1 like); BRG1-associated factor 250b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001085355.1 → NP_001078824.1 AT-rich interactive domain-containing protein 1B

Status: VALIDATED

Source sequence(s)

AC126929, AC166064, BF462904, CK389103

Consensus CDS

CCDS49929.1

UniProtKB/TrEMBL

A0A338P6U8, A0A8Q0PK87

Related

ENSMUSP00000111463.3, ENSMUST00000115797.9

Conserved Domains (4) summary

smart00501
Location:1062 → 1149

BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain

pfam09606
Location:1174 → 1555

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam12031
Location:1935 → 2190

BAF250_C; SWI/SNF-like complex subunit BAF250/Osa

cl26464
Location:451 → 863

Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

5044481..5397931

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006523223.5 → XP_006523286.1 AT-rich interactive domain-containing protein 1B isoform X2

See identical proteins and their annotated locations for XP_006523286.1

UniProtKB/TrEMBL

E9Q4N6

Related

ENSMUSP00000111465.2, ENSMUST00000115799.2

Conserved Domains (4) summary

pfam09606
Location:705 → 1086

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd16877
Location:593 → 685

ARID_ARID1B; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 1B (ARID1B) and similar proteins

pfam12031
Location:1466 → 1721

BAF250_C; SWI/SNF-like complex subunit BAF250/Osa

pfam15362
Location:163 → 363

Enamelin
XM_006523221.5 → XP_006523284.2 AT-rich interactive domain-containing protein 1B isoform X1

UniProtKB/Swiss-Prot

E9Q4N7

UniProtKB/TrEMBL

A0A338P6U8

Related

ENSMUSP00000090398.5, ENSMUST00000092723.11

Conserved Domains (4) summary

PHA03307
Location:568 → 923

PHA03307; transcriptional regulator ICP4; Provisional

pfam09606
Location:1237 → 1617

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd16877
Location:1124 → 1216

ARID_ARID1B; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 1B (ARID1B) and similar proteins

pfam12031
Location:1997 → 2252

BAF250_C; SWI/SNF-like complex subunit BAF250/Osa