smo smoothened [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: smoprovided by FlyBase
Official Full Name: smoothenedprovided by FlyBase
Primary source: FLYBASE:FBgn0003444
Locus tag: Dmel_CG11561
See related: AllianceGenome:FB:FBgn0003444
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11561; Dmel\CG11561; dSmo; Smo; SMO
Summary: Enables phosphatidylinositol-4-phosphate binding activity; protein homodimerization activity; and protein kinase binding activity. Involved in several processes, including animal organ morphogenesis; negative regulation of G1/S transition of mitotic cell cycle; and segment polarity determination. Located in cilium; dendrite; and neuronal cell body. Is integral component of plasma membrane. Colocalizes with axon. Is expressed in several structures, including anterior ectoderm anlage; ectoderm; epithelium; extended germ band embryo; and wing disc. Used to study primary bacterial infectious disease. Human ortholog(s) of this gene implicated in basal cell carcinoma; hepatocellular carcinoma; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human SMO (smoothened, frizzled class receptor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 21B7-21B7; 2-0.5 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (277582..282167)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (277582..282167)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphatidic acid binding to Patched contributes to the inhibition of Smoothened and Hedgehog signaling in Drosophila wing development.
Title: Phosphatidic acid binding to Patched contributes to the inhibition of Smoothened and Hedgehog signaling in Drosophila wing development.
Structural basis for binding of Drosophila Smaug to the GPCR Smoothened and to the germline inducer Oskar.
Title: Structural basis for binding of Drosophila Smaug to the GPCR Smoothened and to the germline inducer Oskar.
Distinct roles of Bendless in regulating FSC niche competition and daughter cell differentiation.
Title: Distinct roles of Bendless in regulating FSC niche competition and daughter cell differentiation.
Mechanisms of Smoothened Regulation in Hedgehog Signaling.
Title: Mechanisms of Smoothened Regulation in Hedgehog Signaling.
Dual functions of Rack1 in regulating Hedgehog pathway.
Title: Dual functions of Rack1 in regulating Hedgehog pathway.
Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling to promote skeletal tissue homeostasis.
Title: Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling to promote skeletal tissue homeostasis.
Data show that hedgehog (Hh)-induced phosphorylation of signal transducer Smoothened (Smo) inhibits smurf E3 ligase (Smurf) recruitment to Smo.
Title: Hedgehog reciprocally controls trafficking of Smo and Ptc through the Smurf family of E3 ubiquitin ligases.
UCHL5 interacts with and deubiquitinates Smo, increasing stability and promoting accumulation at the cell membrane.
Title: The deubiquitinase UCHL5/UCH37 positively regulates Hedgehog signaling by deubiquitinating Smoothened.
inactivation of the ESCRT-III causes dramatic accumulation of Smo in the ESCRT-III/MVB compartment, and subsequent activation of Hedgehog signaling
Title: An intracellular activation of Smoothened that is independent of Hedgehog stimulation in Drosophila.
This study observed an unexpected and significant Galphas -dependent increase in cAMP levels in response to strong Smo activation in Smo-transfected cells.
Title: Activation of Smoothened in the Hedgehog pathway unexpectedly increases Gα(s)-dependent cAMP levels in Drosophila.

Submit: New GeneRIF Correction See all GeneRIFs (52)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables patched binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-4-phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Bolwig's organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterior/posterior lineage restriction, imaginal disc	TAS Traceable Author Statement more info	PubMed
involved_in blastoderm segmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in commissural neuron axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye-antennal disc morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in follicle cell of egg chamber development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mucosal immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pattern specification process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in segment polarity determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in smoothened signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in smoothened signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in somatic stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc anterior/posterior pattern formation	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: smoothened

Names: CG11561-PA; smo-PA; smooth; smoothene

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

277582..282167

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078719.4 → NP_523443.1 smoothened [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523443.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B7FNK1, P91682, Q9VPM8

UniProtKB/TrEMBL

Q86PA9

Related

FBpp0077788

Conserved Domains (2) summary

cd07451
Location:86 → 221

CRD_SMO; Cysteine-rich domain of the smoothened receptor (Smo) integral membrane protein

pfam01534
Location:246 → 568

Frizzled; Frizzled/Smoothened family membrane region