Cd180 CD180 antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd180provided by MGI
Official Full Name: CD180 antigenprovided by MGI
Primary source: MGI:MGI:1194924
See related: Ensembl:ENSMUSG00000021624 AllianceGenome:MGI:1194924
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ly78; Ly-78; RP105; F630107B15
Summary: Predicted to enable transmembrane signaling receptor activity. Acts upstream of or within B cell proliferation involved in immune response; cellular response to lipopolysaccharide; and positive regulation of lipopolysaccharide-mediated signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human CD180 (CD180 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 14.3), mammary gland adult (RPKM 3.5) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 D1; 13 54.92 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (102830055..102843139)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (102693547..102706631)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Distinct contributions of the innate immune receptors TLR2 and RP105 to formation and architecture of structured lung granulomas in mice infected with Mycobacterium tuberculosis.
Title: Distinct contributions of the innate immune receptors TLR2 and RP105 to formation and architecture of structured lung granulomas in mice infected with Mycobacterium tuberculosis.
RP105 protects against ischemic and septic acute kidney injury via suppressing TLR4/NF-kappaB signaling pathways.
Title: RP105 protects against ischemic and septic acute kidney injury via suppressing TLR4/NF-κB signaling pathways.
Targeting Antigens to CD180 but Not CD40 Programs Immature and Mature B Cell Subsets to Become Efficient APCs.
Title: Targeting Antigens to CD180 but Not CD40 Programs Immature and Mature B Cell Subsets to Become Efficient APCs.
A critical role of CD180 in regulating TLR7- and TLR9-mediated activation of macrophages and DCs.
Title: CD180 Ligation Inhibits TLR7- and TLR9-Mediated Activation of Macrophages and Dendritic Cells Through the Lyn-SHP-1/2 Axis in Murine Lupus.
the impaired venous OR in RP105(-/-) mice could result from of a shift in both macrophages and VSMCs towards a regenerative phenotype, identifying a novel relationship between inflammation and VSMC function in AVF maturation.
Title: Deficiency of TLR4 homologue RP105 aggravates outward remodeling in a murine model of arteriovenous fistula failure.
The present study shows that a noncanonical Toll-like receptor complex, CD180/MD-1, is specifically expressed on Multiple myeloma cells and senses bacterial lipopolysaccharide to transduce proliferative signals, leading to the regrowth of dormant Multiple myeloma clones.
Title: Myeloma Cells Are Activated in Bone Marrow Microenvironment by the CD180/MD-1 Complex, Which Senses Lipopolysaccharide.
Silencing Cd180 results in increased phagocytosis while tempering the production of the proinflammatory cytokine TNF during Borrelia burgdorferi infection.
Title: A multi-omic analysis reveals the regulatory role of CD180 during the response of macrophages to Borrelia burgdorferi.
the close association between the increased proportion of CD180-negative B cells and the activation of IFN-alpha signaling in Systemic lupus erythematosus, is reported.
Title: Ligation of CD180 inhibits IFN-α signaling in a Lyn-PI3K-BTK-dependent manner in B cells.
Data show that RP105 knockout (-/-) smooth muscle cells and mast cells secreted higher levels of chemokine (C-C motif) ligand 2 protein (CCL2).
Title: Deficiency of the TLR4 analogue RP105 aggravates vein graft disease by inducing a pro-inflammatory response.
These data unveil a novel innate immune signaling axis that orchestrates key cytokine responses of macrophages and provide molecular insight into the functions of RP105 as an innate immune receptor for mycobacteria.
Title: RP105 Engages Phosphatidylinositol 3-Kinase p110δ To Facilitate the Trafficking and Secretion of Cytokines in Macrophages during Mycobacterial Infection.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D37797 (e-PCR)
- UniSTS:124828

D13Mit47 (e-PCR), detects polymorphism
- UniSTS:127147

D37797 (e-PCR)
- UniSTS:163545

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell proliferation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within B cell proliferation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of lipopolysaccharide-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of lipopolysaccharide-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of lipopolysaccharide-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of lipopolysaccharide-mediated signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CD180 antigen

Names: lymphocyte antigen 78; radioprotective 105 kDa protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360519.1 → NP_001347448.1 CD180 antigen isoform 2

Status: VALIDATED

Source sequence(s)

AC239606

Conserved Domains (4) summary

TIGR00864
Location:357 → 431

PCC; polycystin cation channel protein

sd00033
Location:131 → 154

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:228 → 289

LRR_8; Leucine rich repeat

cl26793
Location:81 → 265

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
NM_008533.2 → NP_032559.2 CD180 antigen isoform 1 precursor

See identical proteins and their annotated locations for NP_032559.2

Status: VALIDATED

Source sequence(s)

AK089255, BY222876, BY529039

Consensus CDS

CCDS26741.1

UniProtKB/Swiss-Prot

Q62192, Q8C251

UniProtKB/TrEMBL

Q3U0U7

Related

ENSMUSP00000022124.4, ENSMUST00000022124.10

Conserved Domains (4) summary

smart00082
Location:577 → 626

LRRCT; Leucine rich repeat C-terminal domain

cd00116
Location:345 → 541

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:323 → 346

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:420 → 481

LRR_8; Leucine rich repeat