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    Wdr44 WD repeat domain 44 [ Mus musculus (house mouse) ]

    Gene ID: 72404, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Wdr44provided by MGI
    Official Full Name
    WD repeat domain 44provided by MGI
    Primary source
    MGI:MGI:1919654
    See related
    Ensembl:ENSMUSG00000036769 AllianceGenome:MGI:1919654
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RPH11; RAB11BP; 2610034K17Rik
    Summary
    This gene encodes a protein containing multiple WD repeats. The encoded protein may play a role in vesicle trafficking. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
    Expression
    Ubiquitous expression in bladder adult (RPKM 2.9), CNS E18 (RPKM 2.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Wdr44 in Genome Data Viewer
    Location:
    X A2; X 17.36 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (23559231..23672265)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (23692402..23806026)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46917 Neighboring gene VISTA enhancer mm1395 Neighboring gene predicted gene, 26131 Neighboring gene STARR-seq mESC enhancer starr_46918 Neighboring gene STARR-seq mESC enhancer starr_46919 Neighboring gene STARR-seq mESC enhancer starr_46920 Neighboring gene kelch-like 13 Neighboring gene STARR-seq mESC enhancer starr_46924 Neighboring gene STARR-seq mESC enhancer starr_46925 Neighboring gene STARR-seq mESC enhancer starr_46926 Neighboring gene cyclin-dependent kinase 2 interacting protein pseudogene Neighboring gene STARR-seq mESC enhancer starr_46927 Neighboring gene STARR-seq mESC enhancer starr_46928 Neighboring gene STARR-seq mESC enhancer starr_46929 Neighboring gene testis derived transcript pseudogene Neighboring gene testin LIM domain protein like 1 Neighboring gene testin LIM domain protein like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Physical and functional interaction of rabphilin-11 with mammalian Sec13 protein. Implication in vesicle trafficking. Mammoto A, et al. J Biol Chem, 2000 May 5. PMID 10747849
    2. VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase. Baron Y, et al. BMC Biol, 2014 May 29. PMID 24885147, Free PMC Article
    3. Phenotypic annotation of the mouse X chromosome. Cox BJ, et al. Genome Res, 2010 Aug. PMID 20548051, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • 9130203L06, DKFZp686L20145

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular sequestering activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytosolic ciliogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 44
    Names
    rab11-binding protein
    rabphilin-11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305675.1 → NP_001292604.1  WD repeat-containing protein 44

      See identical proteins and their annotated locations for NP_001292604.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BB619844, BC068151
      Consensus CDS
      CCDS40892.1
      UniProtKB/Swiss-Prot
      Q3UT13, Q6NVE8, Q8BTS1
      Related
      ENSMUSP00000099193.3, ENSMUST00000101670.3
      Conserved Domains (2) summary
      sd00039
      Location:516 → 607
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:512 → 859
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_175180.3 → NP_780389.2  WD repeat-containing protein 44

      See identical proteins and their annotated locations for NP_780389.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BB619844, BC068151
      Consensus CDS
      CCDS40892.1
      UniProtKB/Swiss-Prot
      Q3UT13, Q6NVE8, Q8BTS1
      Related
      ENSMUSP00000044616.7, ENSMUST00000035766.13
      Conserved Domains (2) summary
      sd00039
      Location:516 → 607
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:512 → 859
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      23559231..23672265
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527700.5 → XP_006527763.1  WD repeat-containing protein 44 isoform X1

      See identical proteins and their annotated locations for XP_006527763.1

      UniProtKB/Swiss-Prot
      Q3UT13, Q6NVE8, Q8BTS1
      Conserved Domains (2) summary
      sd00039
      Location:516 → 607
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:512 → 859
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NVE8.1 GenPept UniProtKB/Swiss-Prot:Q6NVE8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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