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    Sigirr single Ig and TIR domain containing [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309106, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Sigirrprovided by RGD
    Official Full Name
    single Ig and TIR domain containingprovided by RGD
    Primary source
    RGD:1306732
    See related
    Ensembl:ENSRNOG00000015593 AllianceGenome:RGD:1306732
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306732
    Summary
    Predicted to enable NAD+ nucleosidase activity. Predicted to be involved in acute-phase response; negative regulation of cytokine-mediated signaling pathway; and regulation of gene expression. Predicted to be located in membrane. Orthologous to human SIGIRR (single Ig and TIR domain containing). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 111.4), Liver (RPKM 74.9) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sigirr in Genome Data Viewer
    Location:
    1q41
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (205625742..205637883, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (196195363..196208692, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (213898395..213907697, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small EDRK-rich factor 2 pseudogene Neighboring gene beta-1,4-N-acetyl-galactosaminyl transferase 4 Neighboring gene plakophilin 3 Neighboring gene anoctamin 9 Neighboring gene uncharacterized LOC134485202 Neighboring gene RNA, U6 small nuclear 1205

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Bifidobacterium adolescentis protects against necrotizing enterocolitis and upregulates TOLLIP and SIGIRR in premature neonatal rats. Wu W, et al. BMC Pediatr, 2017 Jan 5. PMID 28056921, Free PMC Article
    2. Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily. Thomassen E, et al. Cytokine, 1999 Jun. PMID 10346978
    3. The IL-1 family: regulators of immunity. Sims JE, et al. Nat Rev Immunol, 2010 Feb. PMID 20081871
    4. SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Wald D, et al. Nat Immunol, 2003 Sep. PMID 12925853
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114558

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in acute-phase response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in acute-phase response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in acute-phase response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of Toll signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Toll signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of chemokine production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of chemokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cytokine-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    single Ig IL-1-related receptor
    Names
    TIR8
    single Ig IL-1R-related molecule
    single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
    single immunoglobulin domain-containing IL1R-related protein
    toll/interleukin-1 receptor 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024887.1 → NP_001020058.1  single Ig IL-1-related receptor

      See identical proteins and their annotated locations for NP_001020058.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097488
      UniProtKB/Swiss-Prot
      Q4V892
      UniProtKB/TrEMBL
      A0A8L2QR48, A6HXP1
      Related
      ENSRNOP00000051758.3, ENSRNOT00000054874.3
      Conserved Domains (3) summary
      smart00255
      Location:164 → 309
      TIR; Toll - interleukin 1 - resistance
      pfam13927
      Location:9 → 101
      Ig_3; Immunoglobulin domain
      cd00096
      Location:28 → 32
      Ig; Ig strand B [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      205625742..205637883 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008759990.4 → XP_008758212.1  single Ig IL-1-related receptor isoform X1

      See identical proteins and their annotated locations for XP_008758212.1

      UniProtKB/Swiss-Prot
      Q4V892
      UniProtKB/TrEMBL
      A0A8L2QR48, A6HXP1
      Conserved Domains (3) summary
      smart00255
      Location:164 → 309
      TIR; Toll - interleukin 1 - resistance
      pfam13927
      Location:9 → 101
      Ig_3; Immunoglobulin domain
      cd00096
      Location:28 → 32
      Ig; Ig strand B [structural motif]

    2. XM_006230553.5 → XP_006230615.1  single Ig IL-1-related receptor isoform X1

      See identical proteins and their annotated locations for XP_006230615.1

      UniProtKB/Swiss-Prot
      Q4V892
      UniProtKB/TrEMBL
      A0A8L2QR48, A6HXP1
      Conserved Domains (3) summary
      smart00255
      Location:164 → 309
      TIR; Toll - interleukin 1 - resistance
      pfam13927
      Location:9 → 101
      Ig_3; Immunoglobulin domain
      cd00096
      Location:28 → 32
      Ig; Ig strand B [structural motif]

    3. XM_063263877.1 → XP_063119947.1  single Ig IL-1-related receptor isoform X1

      UniProtKB/Swiss-Prot
      Q4V892
      UniProtKB/TrEMBL
      A0A8L2QR48, A6HXP1

    4. XM_008759989.4 → XP_008758211.1  single Ig IL-1-related receptor isoform X1

      See identical proteins and their annotated locations for XP_008758211.1

      UniProtKB/Swiss-Prot
      Q4V892
      UniProtKB/TrEMBL
      A0A8L2QR48, A6HXP1
      Conserved Domains (3) summary
      smart00255
      Location:164 → 309
      TIR; Toll - interleukin 1 - resistance
      pfam13927
      Location:9 → 101
      Ig_3; Immunoglobulin domain
      cd00096
      Location:28 → 32
      Ig; Ig strand B [structural motif]

    5. XM_039078950.2 → XP_038934878.1  single Ig IL-1-related receptor isoform X2

      Conserved Domains (1) summary
      pfam01582
      Location:7 → 153
      TIR; TIR domain

    6. XM_039078956.2 → XP_038934884.1  single Ig IL-1-related receptor isoform X2

      Conserved Domains (1) summary
      pfam01582
      Location:7 → 153
      TIR; TIR domain

    RNA

    1. XR_010053009.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V892.1 GenPept UniProtKB/Swiss-Prot:Q4V892

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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