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    Cdh19 cadherin 19, type 2 [ Mus musculus (house mouse) ]

    Gene ID: 227485, updated on 9-May-2024

    Summary

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    Official Symbol
    Cdh19provided by MGI
    Official Full Name
    cadherin 19, type 2provided by MGI
    Primary source
    MGI:MGI:3588198
    See related
    Ensembl:ENSMUSG00000047216 AllianceGenome:MGI:3588198
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable cadherin binding activity and calcium ion binding activity. Predicted to be involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell morphogenesis; and cell-cell junction organization. Predicted to be part of catenin complex. Predicted to be active in adherens junction. Is expressed in several structures, including alimentary system; ear; genitourinary system; integumental system; and nervous system. Orthologous to human CDH19 (cadherin 19). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in bladder adult (RPKM 1.4), frontal lobe adult (RPKM 1.1) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdh19 in Genome Data Viewer
    Location:
    1 E2.1; 1 50.78 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (110811802..110905331, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (110888002..110977601, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 64 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01890 Neighboring gene STARR-seq mESC enhancer starr_01891 Neighboring gene AMME chromosomal region gene 1-like pseudogene Neighboring gene STARR-seq mESC enhancer starr_01892 Neighboring gene STARR-seq mESC enhancer starr_01893 Neighboring gene STARR-seq mESC enhancer starr_01894 Neighboring gene STARR-seq mESC enhancer starr_01895 Neighboring gene STARR-seq mESC enhancer starr_01896 Neighboring gene STARR-seq mESC enhancer starr_01897 Neighboring gene nuclear encoded tRNA lysine 7 (anticodon CTT) Neighboring gene RIKEN cDNA 4921525D07 gene Neighboring gene STARR-seq mESC enhancer starr_01898 Neighboring gene STARR-seq mESC enhancer starr_01899 Neighboring gene STARR-seq mESC enhancer starr_01901 Neighboring gene STARR-seq mESC enhancer starr_01902 Neighboring gene STARR-seq mESC enhancer starr_01903 Neighboring gene STARR-seq mESC enhancer starr_01904 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Direct Interaction of Sox10 With Cadherin-19 Mediates Early Sacral Neural Crest Cell Migration: Implications for Enteric Nervous System Development Defects. Huang T, et al. Gastroenterology, 2022 Jan. PMID 34425092
    2. Dual origin of enteric neurons in vagal Schwann cell precursors and the sympathetic neural crest. Espinosa-Medina I, et al. Proc Natl Acad Sci U S A, 2017 Nov 7. PMID 29078343, Free PMC Article
    3. Comparative analysis of type II classic cadherin mRNA distribution patterns in the developing and adult mouse somatosensory cortex and hippocampus suggests significant functional redundancy. Lefkovics K, et al. J Comp Neurol, 2012 May 1. PMID 22102170
    4. Neurodevelopment. Parasympathetic ganglia derive from Schwann cell precursors. Espinosa-Medina I, et al. Science, 2014 Jul 4. PMID 24925912
    5. Phrenic-specific transcriptional programs shape respiratory motor output. Vagnozzi AN, et al. Elife, 2020 Jan 16. PMID 31944180, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Direct Interaction of Sox10 With Cadherin-19 Mediates Early Sacral Neural Crest Cell Migration: Implications for Enteric Nervous System Development Defects.
      Title: Direct Interaction of Sox10 With Cadherin-19 Mediates Early Sacral Neural Crest Cell Migration: Implications for Enteric Nervous System Development Defects.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in adherens junction organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion mediated by cadherin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catenin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    cadherin-19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081386.2 → NP_001074855.1  cadherin-19

      See identical proteins and their annotated locations for NP_001074855.1

      Status: VALIDATED

      Source sequence(s)
      AC101787, AC162899
      Consensus CDS
      CCDS35687.1
      UniProtKB/TrEMBL
      B2RXP4, E9Q3A7
      Related
      ENSMUSP00000092210.4, ENSMUST00000094626.5
      Conserved Domains (2) summary
      cd11304
      Location:150 → 250
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam01049
      Location:617 → 764
      Cadherin_C; Cadherin cytoplasmic region

    2. NM_001356415.1 → NP_001343344.1  cadherin-19

      Status: VALIDATED

      Source sequence(s)
      AC101787, AC162899
      Consensus CDS
      CCDS35687.1
      UniProtKB/TrEMBL
      B2RXP4, E9Q3A7
      Conserved Domains (2) summary
      cd11304
      Location:150 → 250
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam01049
      Location:617 → 764
      Cadherin_C; Cadherin cytoplasmic region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      110811802..110905331 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247991.3 → XP_011246293.1  cadherin-19 isoform X2

      UniProtKB/TrEMBL
      B2RXP4
      Conserved Domains (2) summary
      cd11304
      Location:95 → 195
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam01049
      Location:562 → 709
      Cadherin_C; Cadherin cytoplasmic region

    2. XM_036164614.1 → XP_036020507.1  cadherin-19 isoform X1

      UniProtKB/TrEMBL
      B2RXP4, E9Q3A7
      Conserved Domains (2) summary
      cd11304
      Location:150 → 250
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam01049
      Location:617 → 764
      Cadherin_C; Cadherin cytoplasmic region

    3. XM_036164615.1 → XP_036020508.1  cadherin-19 isoform X3

      Conserved Domains (2) summary
      cd11304
      Location:2 → 93
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam01049
      Location:460 → 607
      Cadherin_C; Cadherin cytoplasmic region
    Nucleotide Protein Strain
    Heading Accession and Version

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