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    TMEM134 transmembrane protein 134 [ Homo sapiens (human) ]

    Gene ID: 80194, updated on 3-Apr-2024

    Summary

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    Official Symbol
    TMEM134provided by HGNC
    Official Full Name
    transmembrane protein 134provided by HGNC
    Primary source
    HGNC:HGNC:26142
    See related
    Ensembl:ENSG00000172663 AllianceGenome:HGNC:26142
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Located in cytosol and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in skin (RPKM 10.7), prostate (RPKM 8.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    11q13.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (67461710..67469251, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (67455835..67463377, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (67229181..67236722, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67203533-67204294 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67204572-67205104 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67205105-67205637 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67205638-67206170 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67206171-67206702 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5098 Neighboring gene protein tyrosine phosphatase receptor type C associated protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5099 Neighboring gene coronin 1B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67209163-67210002 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:67210843-67211682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5101 Neighboring gene G protein-coupled receptor 152 Neighboring gene calcium binding protein 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5102 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5103 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:67236334-67236958 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5104 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:67244852-67245402 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67253051-67254024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5107 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5108 Neighboring gene aryl hydrocarbon receptor interacting protein Neighboring gene microRNA 6752 Neighboring gene phosphatidylinositol transfer protein membrane associated 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67270543-67271292 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67271293-67272042 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3641 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3642

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of transmembrane protein 134 as a novel LMP1-binding protein by using bimolecular fluorescence complementation and an enhanced retroviral mutagen. Talaty P, et al. J Virol, 2012 Oct. PMID 22855487, Free PMC Article
    2. Systematic identification of hepatitis E virus ORF2 interactome reveals that TMEM134 engages in ORF2-mediated NF-κB pathway. Tian Y, et al. Virus Res, 2017 Jan 15. PMID 27899274
    3. Identifying protein partners of CLN8, an ER-resident protein involved in neuronal ceroid lipofuscinosis. Passantino R, et al. Biochim Biophys Acta, 2013 Mar. PMID 23142642
    4. Identification of the Tetraspanin CD9 as an Interaction Partner of Organic Cation Transporters 1 and 2. Snieder B, et al. SLAS Discov, 2019 Oct. PMID 31318583
    5. Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation. Schaafhausen A, et al. Thromb Haemost, 2011 Feb. PMID 21103663

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. screen identified a novel LMP1-binding protein, transmembrane protein 134; Tmem134 affected LMP1-induced NF-kappaB induction
      Title: Identification of transmembrane protein 134 as a novel LMP1-binding protein by using bimolecular fluorescence complementation and an enhanced retroviral mutagen.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ21749, MGC149891

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transmembrane protein 134

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001078650.3 → NP_001072118.1  transmembrane protein 134 isoform b

      See identical proteins and their annotated locations for NP_001072118.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      AA830850, AP003419, BC125134, HY053672
      Consensus CDS
      CCDS41678.1
      UniProtKB/Swiss-Prot
      Q9H6X4
      Related
      ENSP00000377455.3, ENST00000393877.3
      Conserved Domains (1) summary
      pfam05915
      Location:57 → 178
      DUF872; Eukaryotic protein of unknown function (DUF872)

    2. NM_001078651.3 → NP_001072119.1  transmembrane protein 134 isoform c

      See identical proteins and their annotated locations for NP_001072119.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a.
      Source sequence(s)
      AA830850, AP003419, BC013883, HY053672, HY059123
      UniProtKB/Swiss-Prot
      Q9H6X4
      Conserved Domains (1) summary
      pfam05915
      Location:57 → 184
      DUF872; Eukaryotic protein of unknown function (DUF872)

    3. NM_025124.4 → NP_079400.1  transmembrane protein 134 isoform a

      See identical proteins and their annotated locations for NP_079400.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AA830850, AK025402, AP003419, HY053672
      Consensus CDS
      CCDS8167.1
      UniProtKB/Swiss-Prot
      Q08AK4, Q6PJN3, Q9H6X4
      Related
      ENSP00000312615.2, ENST00000308022.7
      Conserved Domains (1) summary
      pfam05915
      Location:57 → 193
      DUF872; Eukaryotic protein of unknown function (DUF872)

    RNA

    1. NR_073409.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate 3' splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA830850, AP003419, BC013883, HY053672

    2. NR_073410.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses alternate splice sites and lacks a 3' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA830850, AP003419, BC013883, BG719036

    3. NR_073411.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate 5' splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA830850, AP003419, BC013883, BM920758, HY053672

    4. NR_073412.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) uses alternate 3' splice sites, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC013883, BX400047, HY053672
      Related
      ENST00000545682.5

    5. NR_073413.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) uses alternate 5' and 3' splice sites, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA830850, AP003419, BC013883, CN336445, HY053672

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      67461710..67469251 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011545268.4 → XP_011543570.1  transmembrane protein 134 isoform X1

      UniProtKB/TrEMBL
      B4DLG6
      Conserved Domains (1) summary
      pfam05915
      Location:57 → 128
      DUF872; Eukaryotic protein of unknown function (DUF872)

    RNA

    1. XR_007062506.1 RNA Sequence

    2. XR_007062507.1 RNA Sequence

    3. XR_950064.4 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      67455835..67463377 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370039.1 → XP_054226014.1  transmembrane protein 134 isoform X1

    RNA

    1. XR_008488458.1 RNA Sequence

    2. XR_008488459.1 RNA Sequence

    3. XR_008488460.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H6X4.1 GenPept UniProtKB/Swiss-Prot:Q9H6X4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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