C9 complement C9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: C9provided by RGD
Official Full Name: complement C9provided by RGD
Primary source: RGD:620319
See related: Ensembl:ENSRNOG00000013736 AllianceGenome:RGD:620319
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Involved in blood coagulation. Predicted to be located in extracellular space and plasma membrane. Predicted to be part of membrane attack complex. Biomarker of polycystic kidney disease. Human ortholog(s) of this gene implicated in age related macular degeneration 15 and complement component 9 deficiency. Orthologous to human C9 (complement C9). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 4226.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 2q16

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (57300510..57348759)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (55573094..55621345)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (55775562..55823807)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The present study thus defines a novel role for ASK1 as a mediator of C5b-9-dependent cell injury.
Title: Role of apoptosis signal-regulating kinase 1 in complement-mediated glomerular epithelial cell injury.
The membrane attack complex of complement induces caspase activation and apoptosis.
Title: The membrane attack complex of complement induces caspase activation and apoptosis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in cell killing	ISO Inferred from Sequence Orthology more info
involved_in complement activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in complement activation, alternative pathway	IEA Inferred from Electronic Annotation more info
involved_in complement activation, classical pathway	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in killing of cells of another organism	IEA Inferred from Electronic Annotation more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of membrane attack complex	IBA Inferred from Biological aspect of Ancestor more info
part_of membrane attack complex	IEA Inferred from Electronic Annotation more info
part_of membrane attack complex	ISO Inferred from Sequence Orthology more info
located_in other organism cell membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: complement component C9

Names: complement component 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_057146.2 → NP_476487.2 complement component C9 precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A6KGF3, F7F389, Q5BKC4

Related

ENSRNOP00000018545.4, ENSRNOT00000018545.6

Conserved Domains (3) summary

smart00209
Location:56 → 106

TSP1; Thrombospondin type 1 repeats

smart00457
Location:309 → 525

MACPF; membrane-attack complex / perforin

pfam00057
Location:114 → 145

Ldl_recept_a; Low-density lipoprotein receptor domain class A