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    serpina10a serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10a [ Danio rerio (zebrafish) ]

    Gene ID: 565064, updated on 19-Jun-2024

    Summary

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    Official Symbol
    serpina10aprovided by ZNC
    Official Full Name
    serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041014-246
    See related
    Ensembl:ENSDARG00000005924 AllianceGenome:ZFIN:ZDB-GENE-041014-246
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-85n7.5
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in thrombophilia. Orthologous to human SERPINA10 (serpin family A member 10). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See serpina10a in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (27371783..27381642, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (27472693..27482552, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box containing 2a, tandem duplicate 1 Neighboring gene ankyrin repeat and SOCS box containing 2a, tandem duplicate 2 Neighboring gene protein phosphatase 4, regulatory subunit 4 Neighboring gene peripherin 2-like b Neighboring gene transmembrane protein 179a, genome duplicate A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Genetic compensation in a stable slc25a46 mutant zebrafish: A case for using F0 CRISPR mutagenesis to study phenotypes caused by inherited disease. Buglo E, et al. PLoS One, 2020. PMID 32208444, Free PMC Article
    2. Proteomic Profiling of Zebrafish Challenged by Spring Viremia of Carp Virus Provides Insight into Skin Antiviral Response. Liu R, et al. Zebrafish, 2020 Apr. PMID 32176570
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045071.2 → NP_001038536.2  serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10a precursor

      See identical proteins and their annotated locations for NP_001038536.2

      Status: PROVISIONAL

      Source sequence(s)
      BC134976
      UniProtKB/TrEMBL
      A4IG87
      Related
      ENSDARP00000020541.8, ENSDART00000010293.11
      Conserved Domains (1) summary
      pfam00079
      Location:33 → 388
      Serpin; Serpin (serine protease inhibitor)

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      27371783..27381642 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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