Gpr6 G protein-coupled receptor 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpr6provided by RGD
Official Full Name: G protein-coupled receptor 6provided by RGD
Primary source: RGD:70939
See related: Ensembl:ENSRNOG00000049580 AllianceGenome:RGD:70939
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable sphingosine-1-phosphate receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to act upstream of or within positive regulation of cytosolic calcium ion concentration. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human GPR6 (G protein-coupled receptor 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 28.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 20q12

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (46072480..46075251, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (44489853..44492624, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (45813169..45815940, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pharmacological evidence of this receptor was found in the brains of mammals and pigeon, but not frog or newt. Bioinfomatics results implicate GPR6 as a possible candidate for the additional WIN55212-2-sensitive receptor.
Title: Investigation of non-CB(1), non-CB(2) WIN55212-2-sensitive G-protein-coupled receptors in the brains of mammals, birds, and amphibians.
C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-beta neurotoxicity
Title: C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-β neurotoxicity.
The localization of GPR6 in HEK293 cells and striatal neurons was assessed.
Title: Constitutively active GPR6 is located in the intracellular compartments.

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General gene information

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Markers

Gpr6 (e-PCR), detects polymorphism
- UniSTS:234031

UniSTS:495955 (e-PCR)
- UniSTS:495955

Gpr6 (e-PCR), detects polymorphism
- UniSTS:495955

AI852874 (e-PCR)
- UniSTS:164436

UniSTS:489566 (e-PCR)
- UniSTS:489566

RH70579 (e-PCR)
- UniSTS:78267

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables sphingosine-1-phosphate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables sphingosine-1-phosphate receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sphingosine-1-phosphate receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: G-protein coupled receptor 6

Names: putative G protein-coupled receptor (CNL3); sphingosine 1-phosphate receptor GPR6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031806.2 → NP_113994.1 G-protein coupled receptor 6

See identical proteins and their annotated locations for NP_113994.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

P51651

UniProtKB/TrEMBL

A6KTC7

Related

ENSRNOP00000067254.1, ENSRNOT00000073276.2

Conserved Domains (2) summary

cd14964
Location:75 → 101

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:74 → 341

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily