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    St3gal4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363040, updated on 2-May-2024

    Summary

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    Official Symbol
    St3gal4provided by RGD
    Official Full Name
    ST3 beta-galactoside alpha-2,3-sialyltransferase 4provided by RGD
    Primary source
    RGD:1303068
    See related
    Ensembl:ENSRNOG00000009850 AllianceGenome:RGD:1303068
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    siat4c; SIAT4-C; ST3GalIV
    Summary
    Enables monosialoganglioside sialyltransferase activity. Predicted to be involved in several processes, including cellular protein modification process; lipid glycosylation; and positive regulation of leukocyte tethering or rolling. Predicted to be located in Golgi cisterna membrane. Predicted to be integral component of membrane. Orthologous to human ST3GAL4 (ST3 beta-galactoside alpha-2,3-sialyltransferase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 277.6), Lung (RPKM 152.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    8q21
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (41673510..41723158, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (33415666..33465319, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (36264741..36314811, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555390 Neighboring gene uncharacterized LOC120094326 Neighboring gene kirre like nephrin family adhesion molecule 3 Neighboring gene uncharacterized LOC120094325 Neighboring gene uncharacterized LOC134480156 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene uncharacterized LOC120094323 Neighboring gene decapping enzyme, scavenger

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Purification and characterization of CMP-NeuAc:GM1 (Gal beta 1-4GalNAc) alpha 2-3 sialyltransferase from rat brain. Gu TJ, et al. FEBS Lett, 1990 Nov 26. PMID 2262006
    2. Association of a 14-3-3 protein with CMP-NeuAc:GM1 alpha 2,3-sialyltransferase. Gao L, et al. Biochem Biophys Res Commun, 1996 Jul 5. PMID 8694795
    3. Cloning of a novel alpha 2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups. Kitagawa H, et al. J Biol Chem, 1994 Jan 14. PMID 8288606
    4. Three genes that encode human beta-galactoside alpha 2,3-sialyltransferases. Structural analysis and chromosomal mapping studies. Chang ML, et al. Glycobiology, 1995 May. PMID 7655169
    5. Mouse beta-galactoside alpha 2,3-sialyltransferases: comparison of in vitro substrate specificities and tissue specific expression. Kono M, et al. Glycobiology, 1997 Jun. PMID 9184827

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acetyllactosaminide alpha-2,3-sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables N-acetyllactosaminide alpha-2,3-sialyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA 7-methylguanosine cap binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sialyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycoprotein biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oligosaccharide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of blood coagulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of blood coagulation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of leukocyte tethering or rolling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of leukocyte tethering or rolling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sialylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4
    Names
    N-acetyllactosaminide alpha-2,3-sialyltransferase
    alpha 2,3-sialyltransferase IV
    alpha-2,3-sialyltransferase ST3Gal IV
    beta-galactoside alpha-2,3-sialyltransferase 4
    gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase
    gal-beta-1,4-GalNAc-alpha-2,3-sialyltransferase
    gal-beta-1,4-GlcNAc-alpha-2,3-sialyltransferase
    sialyltransferase 4C
    NP_001380792.1
    NP_001380793.1
    NP_001380794.1
    NP_001380795.1
    NP_976082.1
    XP_008764282.1
    XP_038937647.1
    XP_063121805.1
    XP_063121806.1
    XP_063121808.1
    XP_063121809.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393863.1 → NP_001380792.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      P61131
      UniProtKB/TrEMBL
      A0A8L2Q6D7
      Related
      ENSRNOP00000013243.6, ENSRNOT00000013243.6
      Conserved Domains (1) summary
      pfam00777
      Location:107 → 331
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. NM_001393864.1 → NP_001380793.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      P61131
      UniProtKB/TrEMBL
      A0A8L2Q6D7
      Related
      ENSRNOP00000079877.1, ENSRNOT00000116357.1
      Conserved Domains (1) summary
      pfam00777
      Location:107 → 331
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    3. NM_001393865.1 → NP_001380794.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8L2Q6D7
      Conserved Domains (1) summary
      pfam00777
      Location:103 → 327
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    4. NM_001393866.1 → NP_001380795.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8L2Q6D7
      Related
      ENSRNOP00000089685.1, ENSRNOT00000099496.1
      Conserved Domains (1) summary
      pfam00777
      Location:103 → 327
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    5. NM_203337.3 → NP_976082.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 1

      See identical proteins and their annotated locations for NP_976082.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      P61131
      UniProtKB/TrEMBL
      A0A8L2Q6D7
      Related
      ENSRNOP00000077981.1, ENSRNOT00000093795.1
      Conserved Domains (1) summary
      pfam00777
      Location:107 → 331
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      41673510..41723158 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265739.1 → XP_063121809.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X6

    2. XM_063265738.1 → XP_063121808.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X5

    3. XM_063265736.1 → XP_063121806.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X3

    4. XM_063265735.1 → XP_063121805.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X1

    5. XM_039081719.2 → XP_038937647.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZNH8
      Conserved Domains (1) summary
      pfam00777
      Location:135 → 359
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    6. XM_008766060.3 → XP_008764282.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X4

      See identical proteins and their annotated locations for XP_008764282.1

      UniProtKB/Swiss-Prot
      P61131
      UniProtKB/TrEMBL
      A0A8L2Q6D7
      Related
      ENSRNOP00000081971.1
      Conserved Domains (1) summary
      pfam00777
      Location:107 → 331
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61131.1 GenPept UniProtKB/Swiss-Prot:P61131

    Gene LinkOut

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