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    Zfp12 zinc finger protein 12 [ Mus musculus (house mouse) ]

    Gene ID: 231866, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zfp12provided by MGI
    Official Full Name
    zinc finger protein 12provided by MGI
    Primary source
    MGI:MGI:99157
    See related
    Ensembl:ENSMUSG00000029587 AllianceGenome:MGI:99157
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf12; Krox-7; Zfp-12; C530015C18
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated and regulation of transcription by RNA polymerase II. Predicted to be located in centrosome and nucleoplasm. Predicted to be active in nucleus. Is expressed in genitourinary system. Orthologous to human ZNF12 (zinc finger protein 12). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 6.7), CNS E14 (RPKM 6.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp12 in Genome Data Viewer
    Location:
    5 G2; 5 82.02 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (143220910..143233712)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (143235138..143248834)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene speedy/RINGO cell cycle regulator family, member E4A Neighboring gene RIKEN cDNA 4930448H16 gene Neighboring gene predicted gene, 38735 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:143996641-143996853 Neighboring gene zinc finger protein 316 Neighboring gene cDNA sequence BC030343 Neighboring gene zinc finger protein 853

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of a mouse multigene family that encodes zinc finger structures. Chavrier P, et al. Mol Cell Biol, 1988 Mar. PMID 2452975, Free PMC Article
    2. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
    3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289589.2 → NP_001276518.1  zinc finger protein 12 isoform 1

      See identical proteins and their annotated locations for NP_001276518.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC123686
      Consensus CDS
      CCDS71702.1
      UniProtKB/Swiss-Prot
      Q7TSI0, Q8C7Q7
      Related
      ENSMUSP00000032591.9, ENSMUST00000032591.15
      Conserved Domains (3) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:251 → 677
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:321 → 341
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001289590.2 → NP_001276519.1  zinc finger protein 12 isoform 3

      See identical proteins and their annotated locations for NP_001276519.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in the 5' region and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC123686
      UniProtKB/TrEMBL
      Q6PB81
      Conserved Domains (2) summary
      COG5048
      Location:167 → 593
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:237 → 257
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001424656.1 → NP_001411585.1  zinc finger protein 12 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC123686
      UniProtKB/Swiss-Prot
      Q7TSI0, Q8C7Q7

    4. NM_001424657.1 → NP_001411586.1  zinc finger protein 12 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC123686
      UniProtKB/TrEMBL
      Q6PB81

    5. NM_001424658.1 → NP_001411587.1  zinc finger protein 12 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC123686
      UniProtKB/TrEMBL
      Q6PB81

    6. NM_177681.5 → NP_808349.1  zinc finger protein 12 isoform 2

      See identical proteins and their annotated locations for NP_808349.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC123686
      Consensus CDS
      CCDS19837.1
      UniProtKB/Swiss-Prot
      Q7TSI0
      Related
      ENSMUSP00000076693.5, ENSMUST00000077485.11
      Conserved Domains (7) summary
      smart00349
      Location:8 → 65
      KRAB; krueppel associated box
      COG5048
      Location:219 → 645
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:289 → 309
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:371 → 393
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:386 → 410
      zf-H2C2_2; Zinc-finger double domain
      cl11841
      Location:7 → 129
      PSII_Pbs27; Photosystem II Pbs27

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      143220910..143233712
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165104.1 → XP_036020997.1  zinc finger protein 12 isoform X3

      Conserved Domains (2) summary
      COG5048
      Location:18 → 452
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:96 → 116
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_017320875.3 → XP_017176364.1  zinc finger protein 12 isoform X1

      UniProtKB/Swiss-Prot
      Q7TSI0, Q8C7Q7
      Conserved Domains (3) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:251 → 677
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:321 → 341
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_011240980.4 → XP_011239282.1  zinc finger protein 12 isoform X3

      See identical proteins and their annotated locations for XP_011239282.1

      Conserved Domains (2) summary
      COG5048
      Location:18 → 452
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:96 → 116
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TSI0.1 GenPept UniProtKB/Swiss-Prot:Q7TSI0

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