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    LINC01503 long intergenic non-protein coding RNA 1503 [ Homo sapiens (human) ]

    Gene ID: 100506119, updated on 19-Feb-2024

    Summary

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    Official Symbol
    LINC01503provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 1503provided by HGNC
    Primary source
    HGNC:HGNC:51184
    See related
    Ensembl:ENSG00000233901 AllianceGenome:HGNC:51184
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Broad expression in urinary bladder (RPKM 4.9), skin (RPKM 4.5) and 21 other tissues See more
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    Genomic context

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    See LINC01503 in Genome Data Viewer
    Location:
    9q34.11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (129336923..129347477)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (141539091..141549647)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (132099202..132109756)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987133 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_106889 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29110 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20371 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29111 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:132083677-132084245 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:132084246-132084813 Neighboring gene long intergenic non-protein coding RNA 2913 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:132086855-132087356 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:132096285-132097484 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:132098075-132098878 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:132098879-132099682 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:132114579-132115380 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:132115381-132116180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:132120510-132121045 Neighboring gene uncharacterized LOC107987038 Neighboring gene RNA, 7SL, cytoplasmic 159, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Long Noncoding RNA LINC01503 Silencing Suppresses KLK4 Expression to Impede Pancreatic Cancer Development as miR-1321 Sponge. An B, et al. Biomed Res Int, 2023. PMID 36785666, Free PMC Article
    2. C-MYC-induced upregulation of LINC01503 promotes progression of non-small cell lung cancer. Zhang ML, et al. Eur Rev Med Pharmacol Sci, 2020 Nov. PMID 33215429
    3. LINC01503/miR-342-3p facilitates malignancy in non-small-cell lung cancer cells via regulating LASP1. Shen Q, et al. Respir Res, 2020 Sep 16. PMID 32938459, Free PMC Article
    4. LncRNA LINC01503 aggravates the progression of cervical cancer through sponging miR-342-3p to mediate FXYD3 expression. Peng X, et al. Biosci Rep, 2020 Jun 26. PMID 32432654, Free PMC Article
    5. Long Non-coding RNA LINC01503 Promotes Gastric Cancer Cell Proliferation and Invasion by Regulating Wnt Signaling. Ding J, et al. Dig Dis Sci, 2021 Feb. PMID 32207034

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Roles, underlying mechanisms and clinical significances of LINC01503 in human cancers.
      Title: Roles, underlying mechanisms and clinical significances of LINC01503 in human cancers.
    2. The transcript ENST00000444125 of lncRNA LINC01503 promotes cancer stem cell properties of glioblastoma cells via reducing FBXW1 mediated GLI2 degradation.
      Title: The transcript ENST00000444125 of lncRNA LINC01503 promotes cancer stem cell properties of glioblastoma cells via reducing FBXW1 mediated GLI2 degradation.
    3. LINC01503/miR-342-3p facilitates malignancy in non-small-cell lung cancer cells via regulating LASP1.
      Title: LINC01503/miR-342-3p facilitates malignancy in non-small-cell lung cancer cells via regulating LASP1.
    4. C-MYC-induced upregulation of LINC01503 promotes progression of non-small cell lung cancer.
      Title: C-MYC-induced upregulation of LINC01503 promotes progression of non-small cell lung cancer.
    5. Long Non-coding RNA LINC01503 Promotes Gastric Cancer Cell Proliferation and Invasion by Regulating Wnt Signaling.
      Title: Long Non-coding RNA LINC01503 Promotes Gastric Cancer Cell Proliferation and Invasion by Regulating Wnt Signaling.
    6. LncRNA LINC01503 aggravates the progression of cervical cancer through sponging miR-342-3p to mediate FXYD3 expression.
      Title: LncRNA LINC01503 aggravates the progression of cervical cancer through sponging miR-342-3p to mediate FXYD3 expression.
    7. EGR1-mediated linc01503 promotes cell cycle progression and tumorigenesis in gastric cancer.
      Title: EGR1-mediated linc01503 promotes cell cycle progression and tumorigenesis in gastric cancer.
    8. AR-induced long non-coding RNA LINC01503 facilitates proliferation and metastasis via the SFPQ-FOSL1 axis in nasopharyngeal carcinoma.
      Title: AR-induced long non-coding RNA LINC01503 facilitates proliferation and metastasis via the SFPQ-FOSL1 axis in nasopharyngeal carcinoma.
    9. LINC01503 promotes cell proliferation, invasion and EMT process in cholangio-carcinoma.
      Title: LINC01503 promotes cell proliferation, invasion and EMT process in cholangio-carcinoma.
    10. findings suggested that LINC01503 conferred oncogenic function in glioma and may be a new prognostic biomarker and novel therapeutic strategy for this malignancy
      Title: Long non-coding RNA LINC01503 predicts worse prognosis in glioma and promotes tumorigenesis and progression through activation of Wnt/β-catenin signaling.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Other Names

    • hCG2021613
    • lnc-PPP2R4-5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_120685.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      BF432137, DA958985
      Related
      ENST00000660635.1

    2. NR_120686.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site at an internal exon, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AL353803
      Related
      ENST00000444125.4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      129336923..129347477
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      141539091..141549647
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Research Materials